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BEND

Bendable Bioplatform for Electrically stimulated Neuronal Differentiation

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

BEND project word cloud

Explore the words cloud of the BEND project. It provides you a very rough idea of what is the project "BEND" about.

therapy years dementia 2 pivotal differentiated electro alzheimer network desired stimulated pluripotent cells neuron serious replacement 65 western msca 1 conductive life therapies neuro degenerative t disease off substrate neurodegenerative neuronal marie ips 4 deserves accurate people faster direction endeavour parkinson population soft electrical transcriptional circuit bendable generating implantable mature bioplatform diseases huntington excellent countries curie expensive processes proliferation 5 neural poses degeneration double summary irreversible scalable regeneration compensate 3 injuries quality 2015 stem bioelectronics nsc threat opportunity option electrically performed aging pose suitable stimulus differentiation ipsc compensating treating suffering cell vivo neurite

Project "BEND" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY OF GLASGOW Organization address address: UNIVERSITY AVENUE city: GLASGOW postcode: G12 8QQ website: www.gla.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	https://ec.europa.eu/research/participants/grants-app/reporting/REP-704807-1/PeriodicReportForm/technical
Total cost	195˙454 €
EC max contribution	195˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-EF-ST
Starting year	2016
Duration (year-month-day)	from 2016-08-15 to 2018-08-14

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY OF GLASGOW UNIVERSITY OF GLASGOW Organization address address: UNIVERSITY AVENUE city: GLASGOW postcode: G12 8QQ website: www.gla.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (GLASGOW)	coordinator	195˙454.00

Map

Project objective

Summary of Marie Curie Proposal for H2020-MSCA-IF-2015

“Bendable Bioplatform for Electrically stimulated Neuronal Differentiation”

With western countries aging faster, the neurodegenerative diseases like Parkinson’s, Alzheimer’s, Huntington’s etc. pose serious threat to quality of life, especially for people over 65 years[1]. In Europe, number of people suffering with dementia, which results from neuronal degeneration, is on the rise it is expected to be double in the next 20 Years[2]. The neuronal degeneration is irreversible[3] and currently the cell therapy for regeneration of neuron network is the only option to compensate such a loss. Recently, the induced pluripotent stem cell (iPSC) derived NSC therapy has come up as an excellent opportunity in treating of neuro degenerative diseases. However, proliferation and differentiation of iPS cell population in neuronal replacement therapies poses many technical challenges such as targeted neurite differentiation to compensate desired loss with controlled differentiation[4]. Traditionally, the neuronal differentiation of iPSC is performed using several transcriptional and growth factors, which are complex, expensive and non-scalable processes[5]. For this reason, the research for a simple, robust and scalable method for generating large number of mature, differentiated neuronal cell deserves top priority. In addition, an accurate on/off system for scalable proliferation and neuronal differentiation is pivotal for the development of implantable bioelectronics circuit suitable for in vivo application. It is believed that the electrical stimulus controlled neuronal differentiation of stem cells on a soft, bendable electro conductive substrate can be suitable for bioelectronics application and also for compensating neuronal loss in the degenerative disease or injuries. This project is an ambitious endeavour in this direction. A bendable bioplatform will be developed for electrically stimulated neural differentiation t

Publications

List of publications.
year	authors and title	journal	last update
2019	Khudishta Aktar, Abdul Kafi, Ravinder Dahiya Association of Gpx1 fluctuation in cell cycle progression published pages: , ISSN: 1071-2690, DOI: 10.1007/s11626-018-00314-3	In Vitro Cellular & Developmental Biology - Animal	2019-05-10
2019	Md. Abdul Kafi; Ambarish Paul; Anastasios Vilouras; Ravinder Dahiya Chitosan-Graphene Oxide Based Ultra-Thin Conformable Sensing Patch for Cell-Health Monitoring published pages: , ISSN: , DOI:	2018 IEEE SENSORS	2019-05-10
2019	Anastasios Vilouras ; Ambarish Paul ; Md. Abdul Kafi ; Ravinder Dahiya Graphene Oxide-Chitosan Based Ultra-Flexible Electrochemical Sensor for Detection of Serotonin published pages: , ISSN: , DOI:	2018 IEEE SENSORS	2019-05-10

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