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MMBio SIGNED

Molecular Tools for Nucleic Acid Manipulation for Biological Intervention

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

MMBio project word cloud

Explore the words cloud of the MMBio project. It provides you a very rough idea of what is the project "MMBio" about.

science stimulate separate basic expertise synthesis unqiues commercialisation recognition requiring concerted cells industry joint transfer therapeutically grouping breadth opportunity classically train commercial acid skills cellular chemists chemistry molecular single interfere ebiotechnology reactivity quantitative expression educate training ensures combined academic biologists nucleic barriers structured disciplines naturally oligonucleotide biology scientists covered bridge sectorial therapy experts original introduce mmbio utility academia enterprises understand itn young later area experimental hope incorporation array living interactions holds molecules biological medicine solution assembling gene disciplinary drug stag effort chemical communication designed stage

Project "MMBio" data sheet

The following table provides information about the project.

Coordinator	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://www.bioc.cam.ac.uk/hollfelder/Research/mmbio
Total cost	3˙971˙347 €
EC max contribution	3˙971˙347 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2016
Funding Scheme	MSCA-ITN-ETN
Starting year	2017
Duration (year-month-day)	from 2017-01-01 to 2020-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	coordinator	546˙575.00
2	THE UNIVERSITY OF SHEFFIELD THE UNIVERSITY OF SHEFFIELD Organization address address: FIRTH COURT WESTERN BANK city: SHEFFIELD postcode: S10 2TN website: www.shef.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SHEFFIELD)	participant	546˙575.00
3	UNIVERSITA DEGLI STUDI DI PADOVA UNIVERSITA DEGLI STUDI DI PADOVA Organization address address: VIA 8 FEBBRAIO 2 city: PADOVA postcode: 35122 website: www.unipd.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (PADOVA)	participant	516˙122.00
4	MEDIMMUNE LIMITED MEDIMMUNE LIMITED Organization address address: MILSTEIN BUILDING GRANTA PARK city: CAMBRIDGE postcode: CB21 6GH website: http://www.cambridgeantibody.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	273˙287.00
5	TURUN YLIOPISTO TURUN YLIOPISTO Organization address address: YLIOPISTONMAKI city: Turku postcode: 20014 website: www.utu.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (Turku)	participant	269˙145.00
6	UNIVERSITAET BERN UNIVERSITAET BERN Organization address address: HOCHSCHULSTRASSE 6 city: BERN postcode: 3012 website: http://www.unibe.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BERN)	participant	265˙226.00
7	ASTRAZENECA AB ASTRAZENECA AB Organization address address: Vastra Maelarhamnen city: SODERTAELJE postcode: 151 85 website: www.astrazeneca.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (SODERTAELJE)	participant	263˙659.00
8	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	263˙659.00
9	REGION STOCKHOLM REGION STOCKHOLM Organization address address: HANTVERKARGATAN 45 city: STOCKHOLM postcode: 104 22 website: www.sll.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	263˙659.00
10	UNIVERSITEIT GENT UNIVERSITEIT GENT Organization address address: SINT PIETERSNIEUWSTRAAT 25 city: GENT postcode: 9000 website: http://www.ugent.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (GENT)	participant	250˙560.00
11	JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN Organization address address: THEODOR W ADORNO PLATZ 1 city: FRANKFURT AM MAIN postcode: 60323 website: www.uni-frankfurt.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (FRANKFURT AM MAIN)	participant	249˙216.00
12	RISE RESEARCH INSTITUTES OF SWEDEN AB RISE RESEARCH INSTITUTES OF SWEDEN AB Organization address address: BRINELLGATAN 4 city: BORAS postcode: 501 15 website: www.ri.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (BORAS)	participant	234˙363.00
13	SP PROCESS DEVELOPMENT AB SP PROCESS DEVELOPMENT AB Organization address address: PO BOX 857 city: BORAS postcode: 501 15 website: www.sp.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (BORAS)	participant	29˙295.00
14	Alzheimer's Research UK Alzheimer's Research UK Organization address address: 43-44 CRUTCHED FRIARS city: LONDON postcode: EC3N 2AE website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	partner	0.00
15	ANANAS NANOTECH ANANAS NANOTECH Organization address address: via Altinate 120 city: Padova postcode: 35121 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (Padova)	partner	0.00
16	CAMBRIDGE ENTREPRISE LIMITED CAMBRIDGE ENTREPRISE LIMITED Organization address address: CHARLES BABBAGE ROAD HAUSER FORUM 3 city: CAMBRIDGE postcode: CB3 0GT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	partner	0.00
17	DROP-TECH LTD DROP-TECH LTD Organization address address: Canterbury Street, Canterbury Court 91 city: Cambridge postcode: CB4 3QU website: http://www.drop-tech.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (Cambridge)	partner	0.00
18	OLIGOMER SCIENCES AB OLIGOMER SCIENCES AB Organization address address: SVEAVAGEN 18A city: DJURSHOLM postcode: 182 60 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (DJURSHOLM)	partner	0.00
19	Synthena Synthena Organization address address: FREIESTRASSE 3 city: BERN postcode: 3012 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BERN)	partner	0.00

Map

Project objective

MMbio will bridge the classically separate disciplines of Chemistry and Biology by assembling leading experts from academia and non-academic partners (industry, technology transfer & science communication) to bring about systems designed to interfere therapeutically with gene expression in living cells. Expertise in nucleic acid synthesis, its molecular recognition and chemical reactivity is combined with drug delivery, cellular biology and experimental medicine. This project represents a concerted effort to make use of a basic and quantitative understanding of chemical interactions to develop and deliver oligonucleotide molecules of utility for therapy. Our chemical biology approach to this field is ambitious in its breadth and represents a unqiues opportunity to educate young scientists across sectorial and disciplinary barriers. Training will naturally encompass a wide range of skills, requiring a joint effort of chemists and biologists to introduce young researchers in a structured way to and array of research methodologies that no single research grouping could provide. The incorporation of early-stage and later stag ebiotechnology enterprises ensures that commercialisation of methodologies as well as the drug development process is covered in this ITN. We hope that MMBio will train scientists able to understand both the biological problem and the chemistry that holds the possible solution and develop original experimental approaches to stimulate European academic and commercial success in this area.

Deliverables

List of deliverables.
Summer School	Other	2020-03-11 15:11:20
Website, ESR webpages and Moodle operational	Websites, patent fillings, videos etc.	2020-03-11 15:11:20
Science communication course	Other	2020-03-11 15:11:20

Take a look to the deliverables list in detail: detailed list of MMBio deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Czescik, Zamolo, Darbre, Mancin, Scrimin Factors Influencing the Activity of Nanozymes in the Cleavage of an RNA Model Substrate published pages: 2814, ISSN: 1420-3049, DOI: 10.3390/molecules24152814	Molecules 24/15	2020-03-11
2019	Osama Saher, Taavi Lehto, Olof Gissberg, Dhanu Gupta, Oskar Gustafsson, Samir EL Andaloussi, Tamis Darbre, Karin E. Lundin, C. I. Edvard Smith, Rula Zain Sugar and Polymer Excipients Enhance Uptake and Splice-Switching Activity of Peptide-Dendrimer/Lipid/Oligonucleotide Formulations published pages: 666, ISSN: 1999-4923, DOI: 10.3390/pharmaceutics11120666	Pharmaceutics 11/12	2020-03-11
2018	Osama Saher, Cristina S.J. Rocha, Eman M. Zaghloul, Oscar P.B. Wiklander, Susanna Zamolo, Marc Heitz, Kariem Ezzat, Dhanu Gupta, Jean-Louis Reymond, Rula Zain, Florian Hollfelder, Tamis Darbre, Karin E. Lundin, Samir EL Andaloussi, C.I. Edvard Smith Novel peptide-dendrimer/lipid/oligonucleotide ternary complexes for efficient cellular uptake and improved splice-switching activity published pages: 29-40, ISSN: 0939-6411, DOI: 10.1016/j.ejpb.2018.09.002	European Journal of Pharmaceutics and Biopharmaceutics 132	2020-03-11
2018	Rouven Stulz, Johan Meuller, DÅ¾enita BaÅ¾dareviÄ‡, Charlotte Wennbergâ€…Huldt, Roger StrÃ¶mberg, Shalini Andersson, Anders DahlÃ©n A Versatile and Convenient Synthesis of 34 S-Labeled Phosphorothioate Oligonucleotides published pages: 2114-2119, ISSN: 1439-4227, DOI: 10.1002/cbic.201800417	ChemBioChem 19/19	2020-03-11
2018	Madhuri Hande, Sajal Maity, Tuomas LÃ¶nnberg Palladacyclic Conjugate Group Promotes Hybridization of Short Oligonucleotides published pages: 1588, ISSN: 1422-0067, DOI: 10.3390/ijms19061588	International Journal of Molecular Sciences 19/6	2020-03-11

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The information about "MMBIO" are provided by the European Opendata Portal: CORDIS opendata.