ChromatinRemodelling SIGNED
Single-Molecule And Structural Studies Of ATP-Dependent Chromatin Remodelling
Total Cost €
0EC-Contrib. €
0Partnership
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Explore the words cloud of the ChromatinRemodelling project. It provides you a very rough idea of what is the project "ChromatinRemodelling" about.
Project "ChromatinRemodelling" data sheet
The following table provides information about the project.
| Coordinator |
UPPSALA UNIVERSITET
Organization address contact info |
| Coordinator Country | Sweden [SE] |
| Total cost | 1˙498˙954 € |
| EC max contribution | 1˙498˙954 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2016-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-03-01 to 2022-02-28 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UPPSALA UNIVERSITET | SE (UPPSALA) | coordinator | 1˙498˙954.00 |
Map
Project objective
The packaging of genetic information into chromatin regulates a wide range of vital processes that depend on direct access to the DNA template. Many chromatin-interacting complexes impact chromatin structure and their aberrant regulation or dysfunction has been implicated in various cancers and severe developmental disorders. A better understanding of the roles of chromatin-interacting complexes in such disease states requires a detailed mechanistic study. Many chromatin-interacting complexes modify chromatin structure, yet understanding the underlying mechanisms remains a major challenge in the field. Furthermore, how chromatin-interacting complexes are regulated to enable their various functions is incompletely understood. We will address these longstanding questions in two specific aims. Aim I: Building on our expertise in single-molecule biology, we will develop powerful single-molecule imaging approaches to monitor the action of chromatin-interacting complexes in real time. We will further probe how the diverse activities of the chromatin-associated complexes are coordinated and coupled to conformational transitions. Aim II: Drawing on our expertise in structural biology, we will use a range of structural techniques in combination with biochemical approaches to study the vital regulation of chromatin-interacting complexes by their regulatory subunits as well as by chromatin features. We expect to obtain ground-breaking insights into the mechanisms and regulation of disease-related chromatin-associated complexes, which may open up new horizons for developing therapeutic intervention strategies. Furthermore, the approaches developed here will enable the investigation of a large number of chromatin-related processes.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Cédric Romilly, Sebastian Deindl, E. Gerhart H. Wagner The ribosomal protein S1-dependent standby site in tisB mRNA consists of a single-stranded region and a 5′ structure element published pages: 15901-15906, ISSN: 0027-8424, DOI: 10.1073/pnas.1904309116 |
Proceedings of the National Academy of Sciences 116/32 | 2019-10-29 |
| 2019 |
Anton Sabantsev, Robert F. Levendosky, Xiaowei Zhuang, Gregory D. Bowman, Sebastian Deindl Direct observation of coordinated DNA movements on the nucleosome during chromatin remodelling published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-09657-1 |
Nature Communications 10/1 | 2019-06-07 |
| 2018 |
Caroline Ballet, Mário S. P. Correia, Louis P. Conway, Theresa L. Locher, Laura C. Lehmann, Neeraj Garg, Miroslav Vujasinovic, Sebastian Deindl, J.-Matthias Löhr, Daniel Globisch New enzymatic and mass spectrometric methodology for the selective investigation of gut microbiota-derived metabolites published pages: 6233-6239, ISSN: 2041-6520, DOI: 10.1039/c8sc01502c |
Chemical Science 9/29 | 2019-04-21 |
| 2017 |
Laura C. Lehmann, Graeme Hewitt, Shintaro Aibara, Alexander Leitner, Emil Marklund, Sarah L. Maslen, Varun Maturi, Yang Chen, David van der Spoel, J. Mark Skehel, Aristidis Moustakas, Simon J. Boulton, Sebastian Deindl Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1 published pages: 847-859.e7, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2017.10.017 |
Molecular Cell 68/5 | 2019-04-21 |
| 2018 |
Kalle Kipper, Nadja Eremina, Emil Marklund, Sumera Tubasum, Guanzhong Mao, Laura Christina Lehmann, Johan Elf, Sebastian Deindl Structure-guided approach to site-specific fluorophore labeling of the lac repressor LacI published pages: e0198416, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0198416 |
PLOS ONE 13/6 | 2019-04-21 |
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