Opendata, web and dolomites

ROBOCHIP SIGNED

MicroRobotic toolkit to deliver spatiotemporally resolved physicochemical signals and control cell sociology

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ROBOCHIP project word cloud

Explore the words cloud of the ROBOCHIP project. It provides you a very rough idea of what is the project "ROBOCHIP" about.

automated    microrobotic    sociology    cells    wirelessly    links    cell    computational    perturbations    layers    network    micromachines    identification    morphogenesis    minimizes    edge    3d    cutting    communication    microenvironment    effort    exceptional    mechanical    regeneration    imaging    programs    structurally    dexterity    internal    seamlessly    physicochemical    engineer    emergent    models    tissue    mechanochemical    modulate    active    signaling    data    connected    powered    dynamical    micromanipulation    dialogue    resolution    time    fibre    cellular    bioengineering    progression    organisms    external    regulation    simultaneously    fibrillar    hack    multiscale    robotic    engineering    functional    evolution    technologies    perform    visualise    community    move    operations    space    components    act    samples    scaffolds    feedback    drive    mechanisms    interfere    function    signals    proper    treatments    constitute    transmission    biological    ensures    dynamic    correct    throughput    disease    organization    interactions    accurate    spectacular    morphologies    local    platforms    rigorous    tissues    physiologically    aid    members    dimensional    spatiotemporal   

Project "ROBOCHIP" data sheet

The following table provides information about the project.

Coordinator
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

Organization address
address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015
website: www.epfl.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙748˙773 €
 EC max contribution 1˙748˙773 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) coordinator 1˙748˙773.00

Map

 Project objective

Biological organisms have spectacular three-dimensional morphologies in which correct multiscale organization and physicochemical regulation are essential for proper function. Understanding the dynamic interactions among cells connected through a structurally complex three-dimensional (3D) fibre network requires a rigorous system identification effort and engineering analysis. To develop accurate and comprehensive models of cell sociology, we need to identify how several different components act together as a connected system and define high-order emergent programs that constitute layers of signals in time and space. The objective of this proposal is to engineer new microrobotic technologies that can be seamlessly integrated with high-throughput bioengineering platforms and produce physiologically relevant signals to establish an active dialogue with the members of the tissue community and drive the cell-network evolution. We propose to build cutting-edge robotic micromanipulation systems to perform automated operations on 3D biological samples with exceptional dexterity and high spatiotemporal resolution. Wirelessly powered micromachines will modulate local mechanochemical signaling within the tissues and move through fibrillar scaffolds. Multi-functional integrated platforms will simultaneously apply external and internal signals, and advanced imaging systems will visualise whole tissue activity at the cellular resolution. Our data will be used to establish computational models of tissue-level mechanical response to dynamical perturbations with particular focus on transmission of signals and feedback mechanisms. The ability to hack cellular communication links and interfere with the biological processes in 3D systems will lead to a better understanding of morphogenesis and regeneration, and can aid in developing treatments that ensures a microenvironment with a distribution of signals that minimizes disease progression.

 Publications

year authors and title journal last update
List of publications.
2019 Erik Mailand, Bin Li, Jeroen Eyckmans, Nikolaos Bouklas, Mahmut Selman Sakar
Surface and Bulk Stresses Drive Morphological Changes in Fibrous Microtissues
published pages: 975-986, ISSN: 0006-3495, DOI: 10.1016/j.bpj.2019.07.041
Biophysical Journal 117/5 2019-11-08
2019 Haiyan Jia, Erik Mailand, Jiangtao Zhou, Zhangjun Huang, Giovanni Dietler, John M. Kolinski, Xinling Wang, Mahmut Selman Sakar
Universal Soft Robotic Microgripper
published pages: 1803870, ISSN: 1613-6810, DOI: 10.1002/smll.201803870
Small 15/4 2019-11-08
2019 Berna Özkale, Raquel Parreira, Ahmet Bekdemir, Lucio Pancaldi, Ece Özelçi, Claire Amadio, Murat Kaynak, Francesco Stellacci, David J. Mooney, Mahmut Selman Sakar
Modular soft robotic microdevices for dexterous biomanipulation
published pages: 778-788, ISSN: 1473-0197, DOI: 10.1039/c8lc01200h
Lab on a Chip 19/5 2019-11-08
2019 H.-W. Huang, F. E. Uslu, P. Katsamba, E. Lauga, M. S. Sakar, B. J. Nelson
Adaptive locomotion of artificial microswimmers
published pages: eaau1532, ISSN: 2375-2548, DOI: 10.1126/sciadv.aau1532
Science Advances 5/1 2019-11-08
2018 Mahmut Selman Sakar, Brendon M. Baker
Engineering Control over 3D Morphogenesis by Tissue Origami
published pages: 131-132, ISSN: 1534-5807, DOI: 10.1016/j.devcel.2018.01.005
Developmental Cell 44/2 2019-11-07
2018 N. Bouklas, M. S. Sakar, W. A. Curtin
A model for cellular mechanotransduction and contractility at finite strain
published pages: 1754-1770, ISSN: 0044-2267, DOI: 10.1002/zamm.201700368
ZAMM - Journal of Applied Mathematics and Mechanics / Zeitschrift für Angewandte Mathematik und Mechanik 98/10 2019-05-27

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ROBOCHIP" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ROBOCHIP" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

HyperBio (2019)

Vis-NIR Hyperspectral imaging for biomaterial quality control

Read More  

BALANCE (2019)

Mapping Dispersion Spectroscopically in Large Gas-Phase Molecular Ions

Read More  

EASY-IPS (2019)

a rapid and efficient method for generation of iPSC

Read More