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ROBOCHIP SIGNED

MicroRobotic toolkit to deliver spatiotemporally resolved physicochemical signals and control cell sociology

Total Cost €

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EC-Contrib. €

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Partnership

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 ROBOCHIP project word cloud

Explore the words cloud of the ROBOCHIP project. It provides you a very rough idea of what is the project "ROBOCHIP" about.

regulation    spatiotemporal    local    organization    micromanipulation    operations    treatments    accurate    space    act    throughput    mechanical    morphogenesis    imaging    fibrillar    identification    models    sociology    minimizes    communication    structurally    move    external    evolution    interactions    constitute    morphologies    microrobotic    internal    microenvironment    data    micromachines    wirelessly    computational    tissues    fibre    correct    programs    links    modulate    organisms    interfere    engineering    mechanisms    samples    robotic    signals    platforms    engineer    functional    transmission    perform    components    proper    perturbations    dexterity    emergent    multiscale    members    3d    physicochemical    tissue    dynamical    effort    disease    biological    drive    exceptional    rigorous    progression    function    powered    cutting    network    community    cells    aid    visualise    physiologically    connected    dimensional    active    dynamic    automated    mechanochemical    bioengineering    hack    signaling    scaffolds    regeneration    layers    ensures    cellular    resolution    seamlessly    technologies    feedback    cell    edge    simultaneously    time    dialogue    spectacular   

Project "ROBOCHIP" data sheet

The following table provides information about the project.

Coordinator
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

Organization address
address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015
website: www.epfl.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙748˙773 €
 EC max contribution 1˙748˙773 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) coordinator 1˙748˙773.00

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 Project objective

Biological organisms have spectacular three-dimensional morphologies in which correct multiscale organization and physicochemical regulation are essential for proper function. Understanding the dynamic interactions among cells connected through a structurally complex three-dimensional (3D) fibre network requires a rigorous system identification effort and engineering analysis. To develop accurate and comprehensive models of cell sociology, we need to identify how several different components act together as a connected system and define high-order emergent programs that constitute layers of signals in time and space. The objective of this proposal is to engineer new microrobotic technologies that can be seamlessly integrated with high-throughput bioengineering platforms and produce physiologically relevant signals to establish an active dialogue with the members of the tissue community and drive the cell-network evolution. We propose to build cutting-edge robotic micromanipulation systems to perform automated operations on 3D biological samples with exceptional dexterity and high spatiotemporal resolution. Wirelessly powered micromachines will modulate local mechanochemical signaling within the tissues and move through fibrillar scaffolds. Multi-functional integrated platforms will simultaneously apply external and internal signals, and advanced imaging systems will visualise whole tissue activity at the cellular resolution. Our data will be used to establish computational models of tissue-level mechanical response to dynamical perturbations with particular focus on transmission of signals and feedback mechanisms. The ability to hack cellular communication links and interfere with the biological processes in 3D systems will lead to a better understanding of morphogenesis and regeneration, and can aid in developing treatments that ensures a microenvironment with a distribution of signals that minimizes disease progression.

 Publications

year authors and title journal last update
List of publications.
2019 Erik Mailand, Bin Li, Jeroen Eyckmans, Nikolaos Bouklas, Mahmut Selman Sakar
Surface and Bulk Stresses Drive Morphological Changes in Fibrous Microtissues
published pages: 975-986, ISSN: 0006-3495, DOI: 10.1016/j.bpj.2019.07.041
Biophysical Journal 117/5 2019-11-08
2019 Haiyan Jia, Erik Mailand, Jiangtao Zhou, Zhangjun Huang, Giovanni Dietler, John M. Kolinski, Xinling Wang, Mahmut Selman Sakar
Universal Soft Robotic Microgripper
published pages: 1803870, ISSN: 1613-6810, DOI: 10.1002/smll.201803870
Small 15/4 2019-11-08
2019 Berna Özkale, Raquel Parreira, Ahmet Bekdemir, Lucio Pancaldi, Ece Özelçi, Claire Amadio, Murat Kaynak, Francesco Stellacci, David J. Mooney, Mahmut Selman Sakar
Modular soft robotic microdevices for dexterous biomanipulation
published pages: 778-788, ISSN: 1473-0197, DOI: 10.1039/c8lc01200h
Lab on a Chip 19/5 2019-11-08
2019 H.-W. Huang, F. E. Uslu, P. Katsamba, E. Lauga, M. S. Sakar, B. J. Nelson
Adaptive locomotion of artificial microswimmers
published pages: eaau1532, ISSN: 2375-2548, DOI: 10.1126/sciadv.aau1532
Science Advances 5/1 2019-11-08
2018 Mahmut Selman Sakar, Brendon M. Baker
Engineering Control over 3D Morphogenesis by Tissue Origami
published pages: 131-132, ISSN: 1534-5807, DOI: 10.1016/j.devcel.2018.01.005
Developmental Cell 44/2 2019-11-07
2018 N. Bouklas, M. S. Sakar, W. A. Curtin
A model for cellular mechanotransduction and contractility at finite strain
published pages: 1754-1770, ISSN: 0044-2267, DOI: 10.1002/zamm.201700368
ZAMM - Journal of Applied Mathematics and Mechanics / Zeitschrift für Angewandte Mathematik und Mechanik 98/10 2019-05-27

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