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Renaparin SIGNED

Improving kidney transplantation outcome with Renaparin® for patients with End-Stage Renal Disease by attenuating graft ischemia reperfusion injury

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

Renaparin project word cloud

Explore the words cloud of the Renaparin project. It provides you a very rough idea of what is the project "Renaparin" about.

trial kidney efficacy preservation humans binds lining nephrologists realize tissue organ corline awaiting reduces protects prevention substantially data reg iia extracted accelerated criteria activate transplantation supply stored replacement chances survival validate iri injury oxygen internationally basis blood biomedical solution cornerstone natural turn glucose establishing prior compound safe of preliminary connected extend donor constitute strategy immune reperfusion leads technologies wall outcome damaged emphasise shortage kidneys vascular replaces renaparin community commercialisation performed coat preparation pharmaceutical safety organs strategic surgeons pressing flow rejection innate vessels alarming recipient cells lack ischemia repairs lies clinical cell supports drug endothelium host

Project "Renaparin" data sheet

The following table provides information about the project.

Coordinator	CORLINE BIOMEDICAL AB Organization address address: LEFFLERSGATAN 5 city: UPPSALA postcode: 754 50 website: www.corline.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Sweden [SE]
Project website	http://www.corline.se
Total cost	2˙362˙681 €
EC max contribution	2˙362˙681 € (100%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-SMEINST-2-2016-2017
Funding Scheme	SME-2
Starting year	2017
Duration (year-month-day)	from 2017-03-01 to 2020-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	CORLINE BIOMEDICAL AB CORLINE BIOMEDICAL AB Organization address address: LEFFLERSGATAN 5 city: UPPSALA postcode: 754 50 website: www.corline.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (UPPSALA)	coordinator	2˙362˙681.00

Map

Project objective

This project will validate the safety and efficacy of Corline Biomedical’s pharmaceutical compound Renaparin®, a novel cell replacement technology used to coat the lining of the blood vessels of kidneys prior to transplantation. Donor kidneys lack natural blood flow while awaiting transplantation. This can lead to ischemia (a shortage of oxygen and glucose supply to the kidney tissue). When connected to the recipient’s blood flow, this in turn leads to ischemia reperfusion injury (IRI).

Given the alarming shortage of organs available for transplantation in the EU and internationally, the prevention of IRI has become a top priority for the transplantation community. Transplantation surgeons and nephrologists emphasise the pressing need for safe and effective technologies which can improve the outcome of kidney transplantation and extend donor criteria. Renaparin® is used when the kidney has been extracted from the donor and is stored in preservation solution awaiting transplantation. There, it binds to, replaces, repairs and protects damaged kidney cells on the endothelium of the vascular wall. As a result, a kidney is less likely to activate the host’s innate immune system, which increases the chances of organ survival and substantially reduces the likelihood of organ rejection.

The research performed in preparation of further development of Renaparin® strongly supports the drug’s potential to increase the success of kidney transplantation. The activities proposed in this project will bring Renaparin® through a Phase I/IIa clinical trial in humans. The produced clinical safety data and preliminary clinical efficacy data will constitute the basis for further clinical development and commercialisation of the product.

Corline’s strategic focus lies on establishing Renaparin® as a new cell replacement technology in kidney transplantation. This will constitute the cornerstone of Corline’s accelerated growth. The project is the key step to realize this strategy.

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The information about "RENAPARIN" are provided by the European Opendata Portal: CORDIS opendata.

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