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Renaparin SIGNED

Improving kidney transplantation outcome with Renaparin® for patients with End-Stage Renal Disease by attenuating graft ischemia reperfusion injury

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 Renaparin project word cloud

Explore the words cloud of the Renaparin project. It provides you a very rough idea of what is the project "Renaparin" about.

lies    injury    turn    host    lining    damaged    replaces    donor    reg    of    wall    safe    reduces    shortage    transplantation    internationally    kidneys    cornerstone    binds    biomedical    technologies    coat    organ    commercialisation    lack    efficacy    clinical    iia    iri    oxygen    immune    vascular    chances    stored    reperfusion    blood    awaiting    preservation    replacement    prior    ischemia    endothelium    drug    outcome    humans    performed    nephrologists    activate    extend    alarming    corline    pressing    glucose    extracted    emphasise    organs    preliminary    prevention    flow    supports    survival    basis    criteria    accelerated    safety    realize    community    repairs    constitute    supply    rejection    cell    connected    compound    establishing    kidney    data    pharmaceutical    surgeons    substantially    cells    natural    strategic    strategy    innate    validate    renaparin    leads    protects    solution    recipient    vessels    trial    preparation    tissue   

Project "Renaparin" data sheet

The following table provides information about the project.

Coordinator		 CORLINE BIOMEDICAL AB 

Organization address
address: LEFFLERSGATAN 5
city: UPPSALA
postcode: 754 50
website: www.corline.com

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Sweden [SE]
 Project website http://www.corline.se
 Total cost 2˙362˙681 €
 EC max contribution 2˙362˙681 € (100%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SMEINST-2-2016-2017
 Funding Scheme SME-2
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CORLINE BIOMEDICAL AB SE (UPPSALA) coordinator 2˙362˙681.00

Map

 Project objective

This project will validate the safety and efficacy of Corline Biomedical’s pharmaceutical compound Renaparin®, a novel cell replacement technology used to coat the lining of the blood vessels of kidneys prior to transplantation. Donor kidneys lack natural blood flow while awaiting transplantation. This can lead to ischemia (a shortage of oxygen and glucose supply to the kidney tissue). When connected to the recipient’s blood flow, this in turn leads to ischemia reperfusion injury (IRI).

Given the alarming shortage of organs available for transplantation in the EU and internationally, the prevention of IRI has become a top priority for the transplantation community. Transplantation surgeons and nephrologists emphasise the pressing need for safe and effective technologies which can improve the outcome of kidney transplantation and extend donor criteria. Renaparin® is used when the kidney has been extracted from the donor and is stored in preservation solution awaiting transplantation. There, it binds to, replaces, repairs and protects damaged kidney cells on the endothelium of the vascular wall. As a result, a kidney is less likely to activate the host’s innate immune system, which increases the chances of organ survival and substantially reduces the likelihood of organ rejection.

The research performed in preparation of further development of Renaparin® strongly supports the drug’s potential to increase the success of kidney transplantation. The activities proposed in this project will bring Renaparin® through a Phase I/IIa clinical trial in humans. The produced clinical safety data and preliminary clinical efficacy data will constitute the basis for further clinical development and commercialisation of the product.

Corline’s strategic focus lies on establishing Renaparin® as a new cell replacement technology in kidney transplantation. This will constitute the cornerstone of Corline’s accelerated growth. The project is the key step to realize this strategy.

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The information about "RENAPARIN" are provided by the European Opendata Portal: CORDIS opendata.

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