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FIMBUG SIGNED

Heterogeneity in fimbrial length and abundance as a generic regulator of E. coli surface colonization

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

FIMBUG project word cloud

Explore the words cloud of the FIMBUG project. It provides you a very rough idea of what is the project "FIMBUG" about.

physical interactions foresee host hair colloidal multivalent suggests mobile herein single player bonds length chemical read bacteria flow surface unraveling modern 3d basis reflected antibiotic adhesion fimbrial introduce subsequent hypothesis fimbriae binding roles certain actions found fitter bacterial career biomaterial health bacterium nanopatterned expression true loose mechanisms care infections interplay biological difficult tracking implant intricate movement adjust simultaneous attributed structures shifting mechanism colonization understand organelles surfaces immobile necessarily regulatory modes contributor training spreading eradicate resistance mean niches colonizers function heterogeneous regulate biofilm overarching forming influence environmental scientific unexplored firm recording monovalent

Project "FIMBUG" data sheet

The following table provides information about the project.

Coordinator	GOETEBORGS UNIVERSITET Organization address address: VASAPARKEN city: GOETEBORG postcode: 405 30 website: www.gu.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Sweden [SE]
Total cost	185˙857 €
EC max contribution	185˙857 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-ST
Starting year	2018
Duration (year-month-day)	from 2018-01-01 to 2019-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	GOETEBORGS UNIVERSITET GOETEBORGS UNIVERSITET Organization address address: VASAPARKEN city: GOETEBORG postcode: 405 30 website: www.gu.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (GOETEBORG)	coordinator	185˙857.00

Map

Project objective

The aim of my research is to identify generic and physical mechanisms that regulate bacterial colonization and subsequent biofilm formation on biomaterial surfaces. This is an emerging problem in modern health care since biofilm implant-related infections are very difficult to eradicate and thus a main contributor to the development and spreading of antibiotic resistance. A key player is fimbriae; these hair-like surface organelles found on many bacteria are known to strongly promote biofilm formation, which is commonly attributed to fimbriae forming strong surface bonds. By recording in 3D the binding of single bacteria to nanopatterned surfaces we observed that this is not necessarily true; We found that fimbriae due to their heterogeneous distribution in length, rather then forming strong bonds provide bacteria a mean to adjust their surface adhesion, shifting between monovalent, loose and mobile binding to firm multivalent immobile binding modes in response to different flow conditions. This suggests a so far unexplored, regulatory role of fimbriae in the surface colonization process. My overarching aim is therefore to understand the influence of this mechanism on bacterial surface colonization. Specifically, I will test the hypothesis that physical and chemical/colloidal interactions are reflected in these structures and their biological function, providing bacteria evolved roles; In this case, that bacteria with certain fimbrial expression are fitter to be colonizers of certain environmental niches. To investigate this I will introduce new methods, allowing simultaneous read-out of a single-bacterium fimbrial expression and tracking of its movement in 3D. I foresee that this project and the training actions described herein will be the basis for a future scientific career focused on unraveling the intricate interplay between bacteria and their host surfaces.

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The information about "FIMBUG" are provided by the European Opendata Portal: CORDIS opendata.