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AttoDNA SIGNED

AttoDNA: how electronic motions affect the photostability of the genomic material

Total Cost €

EC-Contrib. €

Partnership

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AttoDNA project word cloud

Explore the words cloud of the AttoDNA project. It provides you a very rough idea of what is the project "AttoDNA" about.

threat outstanding elegant photostable motion place electron few regards nuclear encoding rationalising canonical subsequent purely blocks excitation suitable photochemistry material thought property defend aid attosecond first put therapies extends photo electronic standpoint onset femtosecond attodna monomers cancer photodynamic photostability genome rna genomic play dynamics outcome prior repair length transfers enzymes treatment intrinsic ascertaining ionisation damage ensuing protective elucidated mechanisms extracted events time exposure perspective treatments monitoring couple preserving building extreme nucleobases invasive instances nucleobase shown mediated provides itself protection initial prebiotic photobiology solution dna foundations exploring uv movement photochemical fail motions

Project "AttoDNA" data sheet

The following table provides information about the project.

Coordinator	IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ website: http://www.imperial.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	183˙454 €
EC max contribution	183˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-ST
Starting year	2018
Duration (year-month-day)	from 2018-03-01 to 2020-02-29

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ website: http://www.imperial.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	183˙454.00

Map

Project objective

AttoDNA considers the early (attosecond to few-femtosecond) events following photo-excitation/ionisation in DNA/RNA canonical and non-canonical nucleobases for the first time. This involves the electronic movement before the onset of nuclear dynamics, ascertaining the length in which this initial purely electronic motion extends in time and how it affects the ensuing nuclear dynamics and its outcome with regards to the photostability shown by the genomic material from a bottom-up approach. By monitoring the electronic and nuclear motions in canonical and non-canonical nucleobases, the way in which they couple can be elucidated and the specific motions contributing to photostability extracted from a novel standpoint.

Photostability is one of the main properties thought to play a crucial role in the selection of the nucleobase monomers in prebiotic extreme UV exposure, by encoding the genome using the most suitable (photostable) building blocks as an elegant solution to aid in its photo-protective design and thus defend itself against the threat of photochemical damage. Beyond its intrinsic importance given its essential role towards preserving our genomic material, an in-depth knowledge of this outstanding property also provides a unique perspective on the events where these photo-protection mechanisms fail, namely the photo-damage instances, and in the subsequent repair mechanisms mediated by electron transfers as those put in place by enzymes and/or in specific non-invasive treatments like photodynamic therapies, the most widespread treatment for cancer.

The project therefore aims at extending the foundations rationalising DNA's photostability by exploring the potential role of the electronic dynamics prior to the onset of nuclear dynamics for the first time and is expected to have a large impact in the fields of photochemistry and photobiology.

Publications

List of publications.
year	authors and title	journal	last update
2019	Javier Segarraâ€MartÃ, Thierry Tran, Michael J. Bearpark Computing the Ultrafast and Radiationless Electronic Excited State Decay of Cytosine and 5â€methylâ€cytosine Cations: Uncovering the Role of Dynamic Electron Correlation published pages: 856-865, ISSN: 2367-0932, DOI: 10.1002/cptc.201900105	ChemPhotoChem 3/9	2020-02-20
2020	Javier Segarra-MartÃ, Francesco Segatta, Tristan A. Mackenzie, Artur Nenov, Ivan Rivalta, Michael J. Bearpark, Marco Garavelli Modeling multidimensional spectral lineshapes from first principles: application to water-solvated adenine published pages: 219-244, ISSN: 1359-6640, DOI: 10.1039/c9fd00072k	Faraday Discussions 221	2020-02-20
2019	Thierry Tran, Javier Segarra-MartÃ, Michael J. Bearpark, Michael A. Robb Molecular Vertical Excitation Energies Studied with First-Order RASSCF (RAS[1,1]): Balancing Covalent and Ionic Excited States published pages: 5223-5230, ISSN: 1089-5639, DOI: 10.1021/acs.jpca.9b03715	The Journal of Physical Chemistry A 123/25	2020-02-20
2019	Javier Segarra-MartÃ, Thierry Tran, Michael J. Bearpark Ultrafast and radiationless electronic excited state decay of uracil and thymine cations: computing the effects of dynamic electron correlation published pages: 14322-14330, ISSN: 1463-9076, DOI: 10.1039/c8cp07189f	Physical Chemistry Chemical Physics 21/26	2020-02-20

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The information about "ATTODNA" are provided by the European Opendata Portal: CORDIS opendata.