Explore the words cloud of the AMYPAD project. It provides you a very rough idea of what is the project "AMYPAD" about.
The following table provides information about the project.
Coordinator |
STICHTING VUMC
Organization address contact info |
Coordinator Country | Netherlands [NL] |
Project website | https://amypad.eu/ |
Total cost | 27˙329˙288 € |
EC max contribution | 11˙999˙886 € (44%) |
Programme |
1. H2020-EU.3.1.7. (Innovative Medicines Initiative 2 (IMI2)) |
Code Call | H2020-JTI-IMI2-2015-05-two-stage |
Funding Scheme | IMI2-RIA |
Starting year | 2016 |
Duration (year-month-day) | from 2016-10-01 to 2021-09-30 |
Take a look of project's partnership.
Beta-amyloid (β-amyloid) deposition is considered to be a necessary - but not sufficient - step on the path towards Alzheimer’s disease (AD). Depiction of brain β-amyloid in vivo can support an early diagnosis, and even provide an opportunity for consider secondary prevention of AD. Currently, however, the value of β-amyloid PET remains elusive, reason why this procedure is typically not reimbursed.
Understanding the value of imaging of β-amyloid using positron emission tomography (PET) provides a unique opportunity to achieve 3 major goals: 1) improve the diagnostic workup of patients suspected of AD and their management; 2) stratify risk for AD and select homogenous groups for intervention; and 3) quantify treatment effects more accurately.
AMYPAD will address the above objectives by studying the onset, dynamics, and clinical relevance of brain β-amyloid in the spectrum from normal aging to preclinical and prodromal AD. We will use β-amyloid-PET in an unprecedented large number of subjects (n=4000) from population studies, as well as memory clinics cohorts, with repeat imaging in up to 2000. In close collaboration with EPAD (www.ep-ad.org), the cohorts will be followed with to determine (surrogate) outcomes of cognitive decline and neurodegeneration.
Lead from VU-VUmc, the Consortium brings together a word-class team of highly synergistic partners from across Europe constituting a highly experienced and efficient β-amyloid imaging network including the most active European PET sites, to ensure effective tracer delivery, access to patients and expertise to technical knowledge and disease modelling.
AMYPAD will establish the true value of β-amyloid PET across the severity range of AD. Patients and clinicians will benefit from better and cost-effective diagnostic procedures and management, while academics and industry will benefit from better disease understanding, clear reimbursement strategy and more rationale and efficient clinical trial design.
year | authors and title | journal | last update |
---|---|---|---|
2019 |
Fiona Heeman, Maqsood Yaqub, Isadora Lopes Alves, Kerstin Heurling, Johannes Berkhof, Juan Domingo Gispert, Santiago Bullich, Christopher Foley, Adriaan A. Lammertsma Optimized dual-time-window protocols for quantitative [18F]flutemetamol and [18F]florbetaben PET studies published pages: , ISSN: 2191-219X, DOI: 10.1186/s13550-019-0499-4 |
EJNMMI Research 9/1 | 2020-03-17 |
2020 |
Frank Jessen, Rebecca E Amariglio, Rachel F Buckley, Wiesje M van der Flier, Ying Han, José Luis Molinuevo, Laura Rabin, Dorene M Rentz, Octavio Rodriguez-Gomez, Andrew J Saykin, Sietske A M Sikkes, Colette M Smart, Steffen Wolfsgruber, Michael Wagner The characterisation of subjective cognitive decline published pages: 271-278, ISSN: 1474-4422, DOI: 10.1016/s1474-4422(19)30368-0 |
The Lancet Neurology 19/3 | 2020-03-17 |
2019 |
Enrico Fantoni, Lyduine Collij, Isadora Lopes Alves, Christopher Buckley, Gill Farrar The spatial-temporal ordering of amyloid pathology and opportunities for PET imaging published pages: jnumed.119.23587, ISSN: 0161-5505, DOI: 10.2967/jnumed.119.235879 |
Journal of Nuclear Medicine | 2020-03-17 |
2018 |
Mara ten Kate, Silvia Ingala, Adam J. Schwarz, Nick C. Fox, Gaël Chételat, Bart N. M. van Berckel, Michael Ewers, Christopher Foley, Juan Domingo Gispert, Derek Hill, Michael C. Irizarry, Adriaan A. Lammertsma, José Luis Molinuevo, Craig Ritchie, Philip Scheltens, Mark E. Schmidt, Pieter Jelle Visser, Adam Waldman, Joanna Wardlaw, Sven Haller, Frederik Barkhof Secondary prevention of Alzheimer’s dementia: neuroimaging contributions published pages: , ISSN: 1758-9193, DOI: 10.1186/s13195-018-0438-z |
Alzheimer\'s Research & Therapy 10/1 | 2020-03-17 |
2017 |
Giovanni B Frisoni, Marina Boccardi, Frederik Barkhof, Kaj Blennow, Stefano Cappa, Konstantinos Chiotis, Jean-Francois Démonet, Valentina Garibotto, Panteleimon Giannakopoulos, Anton Gietl, Oskar Hansson, Karl Herholz, Clifford R Jack, Flavio Nobili, Agneta Nordberg, Heather M Snyder, Mara Ten Kate, Andrea Varrone, Emiliano Albanese, Stefanie Becker, Patrick Bossuyt, Maria C Carrillo, Chiara Cera Strategic roadmap for an early diagnosis of Alzheimer\'s disease based on biomarkers published pages: 661-676, ISSN: 1474-4422, DOI: 10.1016/S1474-4422(17)30159-X |
The Lancet Neurology 16/8 | 2020-03-17 |
2017 |
Matthias J. Ehrhardt, Pawel J. Markiewicz, Peter Richtárik, Jonathan Schott, Antonin Chambolle, Carola-Bibiane Schoenlieb Faster PET reconstruction with a stochastic primal-dual hybrid gradient method published pages: 58, ISSN: 1061-2464, DOI: 10.1117/12.2272946 |
Wavelets and Sparsity XVII Proceedings Volume 10394, Wavel | 2020-03-17 |
2018 |
José Luis Molinuevo, Carolina Minguillon, Lorena Rami, Juan Domingo Gispert The Rationale Behind the New Alzheimer’s Disease Conceptualization: Lessons Learned During the Last Decades published pages: 1067-1077, ISSN: 1387-2877, DOI: 10.3233/JAD-170698 |
Journal of Alzheimer\'s Disease 62/3 | 2020-03-17 |
2019 |
Giovanni B Frisoni, Isadora Lopes Alves, Frederik Barkhof IDEAS becoming reality on the roadmap for biomarker validation in Alzheimer\'s disease published pages: 519-520, ISSN: 1474-4422, DOI: 10.1016/s1474-4422(19)30166-8 |
The Lancet Neurology 18/6 | 2020-03-17 |
2019 |
Lyduine E. Collij, Elles Konijnenberg, Juhan Reimand, Mara ten Kate, Anouk den Braber, Isadora Lopes Alves, Marissa Zwan, Maqsood Yaqub, Daniëlle M.E. van Assema, Alle Meije Wink, Adriaan A. Lammertsma, Philip Scheltens, Pieter Jelle Visser, Frederik Barkhof, Bart N.M. van Berckel Assessing Amyloid Pathology in Cognitively Normal Subjects Using 18 F-Flutemetamol PET: Comparing Visual Reads and Quantitative Methods published pages: 541-547, ISSN: 0161-5505, DOI: 10.2967/jnumed.118.211532 |
Journal of Nuclear Medicine 60/4 | 2020-03-17 |
2019 |
Damiano Archetti, Silvia Ingala, Vikram Venkatraghavan, Viktor Wottschel, Alexandra L. Young, Maura Bellio, Esther E. Bron, Stefan Klein, Frederik Barkhof, Daniel C. Alexander, Neil P. Oxtoby, Giovanni B. Frisoni, Alberto Redolfi Multi-study validation of data-driven disease progression models to characterize evolution of biomarkers in Alzheimer\'s disease published pages: 101954, ISSN: 2213-1582, DOI: 10.1016/j.nicl.2019.101954 |
NeuroImage: Clinical 24 | 2020-03-17 |
2018 |
Pawel J. Markiewicz, Matthias J. Ehrhardt, Kjell Erlandsson, Philip J. Noonan, Anna Barnes, Jonathan M. Schott, David Atkinson, Simon R. Arridge, Brian F. Hutton, Sebastien Ourselin NiftyPET: a High-throughput Software Platform for High Quantitative Accuracy and Precision PET Imaging and Analysis published pages: 95-115, ISSN: 1539-2791, DOI: 10.1007/s12021-017-9352-y |
Neuroinformatics 16/1 | 2020-03-17 |
2018 |
Giovanni B. Frisoni, Frederik Barkhof, Daniele Altomare, Johannes Berkhof, Marina Boccardi, Elisa Canzoneri, Lyduine Collij, Alexander Drzezga, Gill Farrar, Valentina Garibotto, Rossella Gismondi, Juan-Domingo Gispert, Frank Jessen, Miia Kivipelto, Isadora Lopes Alves, José-Luis Molinuevo, Agneta Nordberg, Pierre Payoux, Craig Ritchie, Irina Savicheva, Philip Scheltens, Mark E. Schmidt, Jonathan Schott, Andrew Stephens, Bart van Berckel, Bruno Vellas, Zuzana Walker, Nicola Raffa AMYPAD Diagnostic and Patient Management Study: Rationale and design published pages: , ISSN: 1552-5260, DOI: 10.1016/j.jalz.2018.09.003 |
Alzheimer\'s & Dementia | 2020-03-17 |
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "AMYPAD" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "AMYPAD" are provided by the European Opendata Portal: CORDIS opendata.