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ESCRT model SIGNED

A biophysical model for ESCRT-III mediated membrane scission

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

ESCRT model project word cloud

Explore the words cloud of the ESCRT model project. It provides you a very rough idea of what is the project "ESCRT model" about.

despite solid migration unifying intense escrt model fission function remodeling release reconstitution action cellular molecular escrts questions mediate proteins minimal variety cancer characterization nuclear contribution scission machinery cell pathogenesis constitute outstanding unanswered conserved diseases evolutionary my membrane preliminary implicated speculative repair obtain mechanism data curvature virus vitro

Project "ESCRT model" data sheet

The following table provides information about the project.

Coordinator	INSTITUT CURIE Organization address address: rue d'Ulm 26 city: PARIS postcode: 75231 website: www.curie.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Project website	https://science.curie.fr/members/nicola-de-franceschi/
Total cost	185˙076 €
EC max contribution	185˙076 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-04-01 to 2019-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUT CURIE INSTITUT CURIE Organization address address: rue d'Ulm 26 city: PARIS postcode: 75231 website: www.curie.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	coordinator	185˙076.00

Map

Project objective

My project focuses on the characterization of the mechanism of action of ESCRT-III complex. ESCRTs are evolutionary conserved proteins which mediate membrane remodeling and scission in a variety of important cellular processes, and are implicated in the pathogenesis of many diseases, including virus release and nuclear membrane repair during cancer cell migration. Despite intense research, many outstanding questions still remain unanswered, and all model proposed remain highly speculative. Based on our preliminary data, we propose a novel, unifying model for ESCRT-III function. The aim of the project is to provide solid data to support this model by an in vitro reconstitution approach, which would constitute a major contribution in the field. The concrete aims of my project are:

- Characterization of the minimal ESCRT-III fission machinery - Characterization of the molecular mechanism leading to membrane fission by ESCRT-III complex - Characterization of the membrane requirements to obtain fission by ESCRT-III, in particular membrane curvature

Publications

List of publications.
year	authors and title	journal	last update
2018	De Franceschi Nicola, Alqabandi Maryam, Miguet Nolwenn, Caillat Christophe, Mangenot Stephanie, Weissenhorn Winfried, Bassereau Patricia. The ESCRT protein CHMP2B acts as a diffusion barrier on reconstituted membrane necks published pages: , ISSN: 0021-9533, DOI:	Journal of Cell Science	2019-03-11

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