Explore the words cloud of the INTUMORX project. It provides you a very rough idea of what is the project "INTUMORX" about.
The following table provides information about the project.
Coordinator |
HELSINGIN YLIOPISTO
Organization address contact info |
Coordinator Country | Finland [FI] |
Total cost | 1˙972˙905 € |
EC max contribution | 1˙972˙905 € (100%) |
Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
Code Call | ERC-2016-STG |
Funding Scheme | ERC-STG |
Starting year | 2017 |
Duration (year-month-day) | from 2017-07-01 to 2022-06-30 |
Take a look of project's partnership.
# | ||||
---|---|---|---|---|
1 | HELSINGIN YLIOPISTO | FI (HELSINGIN YLIOPISTO) | coordinator | 1˙972˙905.00 |
The considerable variability within tissue microenvironments as well as the multiclonality of cancers leads to intratumoral heterogeneity. This increases the probablility of cellular states that promote resistance to therapy and eventually lead to reconstitution of the tumor by treatment-resistant cancer cells, which in some cases have properties of normal tissue stem cells. Wnt signals are important in the maintenance of stem cells in various epithelial tissues, including in lung development and regeneration. We hypothesized that Wnt signals contribute to tumor heterogeneity in genetically engineered KrasG12D; Tp53Δ/Δ (”KP”) mouse lung adenocarcinomas (LUAD). We observed that a subpopulation of LUAD cells exhibited high Wnt reporter activity and had increased tumor forming ability, which could be suppressed by silencing of Wnt signaling pathway components or by small molecule Wnt inhibitors in vitro and in vivo. KP LUAD cells show hierarchical features with two distinct populations, one with increased Wnt reporter activity and another forming a niche that provides the Wnt signal. Lineage-tracing experiments in the autochthonous KP tumors demonstrated that Wnt responder cells have increased tumor propagation ability in vivo. Strikingly, selective ablation of the Wnt responder cells resulted in tumor stasis. CRISPR-based targeting or small molecules targeting Wnt signaling reduced tumor growth and prolonged survival in the autochthonous KP mouse lung cancer model. These results indicate that maintenance of heterogeneity within tumors may be advantageous for the tumor cell population collectively. We propose to elucidate the molecular and cellullar mechanisms that control stem-like and niche cell phenotypes using a combination of novel lentiviral vectors and genetically modified mice in the context of the KP LUAD model. These efforts may lead to novel therapeutic concepts in human lung cancer.
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "INTUMORX" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "INTUMORX" are provided by the European Opendata Portal: CORDIS opendata.
Why is the world green: testing top-down control of plant-herbivore food webs by experiments with birds, bats and ants
Read MoreHigh-throughput single-cell phenotypic analysis of functional antibody repertoires
Read MoreOptimization and historical contingency in living systems: a biophysical approach
Read More