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PIGSs SIGNED

Program for Innovative Global Prevention of Streptococcus suis.

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

PIGSs project word cloud

Explore the words cloud of the PIGSs project. It provides you a very rough idea of what is the project "PIGSs" about.

diagnostic genome farms adult carriage global reported genotypes producing pathogenesis losses pork sequencing vaccine prescribe porcine industry exist risk invasive environment strategies prevention serotypes countries 1500 economic tested mechanisms monitoring types primary dynamics reared maturation endemic geographic infections suis preventative morbidity worldwide host microbiota co representative asymptomatic disease amino humans properly first epidemiology farm strengthen immune nature mortality zoonotic significantly causing innate stimulation young interactions virulence outputs infection manipulation combined penicillin frequent time meat streptococcus group conserved isolates antigens base antibiotics pigs lack pathotypes pathogen performing 1200 association on

Project "PIGSs" data sheet

The following table provides information about the project.

Coordinator	WAGENINGEN UNIVERSITY Organization address address: DROEVENDAALSESTEEG 4 city: WAGENINGEN postcode: 6708 PB website: http://www.wageningenur.nl/nl.htm contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	https://www.pigss-horizon2020.eu
Total cost	4˙998˙103 €
EC max contribution	4˙998˙103 € (100%)
Programme	1. H2020-EU.3.2.1.1. (Increasing production efficiency and coping with climate change, while ensuring sustainability and resilience)
Code Call	H2020-SFS-2016-2
Funding Scheme	RIA
Starting year	2017
Duration (year-month-day)	from 2017-06-01 to 2021-11-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	WAGENINGEN UNIVERSITY WAGENINGEN UNIVERSITY Organization address address: DROEVENDAALSESTEEG 4 city: WAGENINGEN postcode: 6708 PB website: http://www.wageningenur.nl/nl.htm contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (WAGENINGEN)	coordinator	1˙153˙795.00
2	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	1˙030˙667.00
3	STICHTING WAGENINGEN RESEARCH STICHTING WAGENINGEN RESEARCH Organization address address: DROEVENDAALSESTEEG 4 city: WAGENINGEN postcode: 6708 PB website: http://www.wageningenur.nl/nl.htm contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (WAGENINGEN)	participant	799˙998.00
4	INSTITUT DE RECERCA I TECNOLOGIA AGROALIMENTARIES INSTITUT DE RECERCA I TECNOLOGIA AGROALIMENTARIES Organization address address: CTRA C-59 KM 12 TORRE MARIMON city: CALDES DE MONTBUI BARCELONA postcode: 8140 website: www.irta.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (CALDES DE MONTBUI BARCELONA)	participant	698˙981.00
5	STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER Organization address address: BUNTEWEG 2 city: HANNOVER postcode: 30559 website: www.tiho-hannover.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HANNOVER)	participant	408˙000.00
6	ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Organization address address: MEIBERGDREEF 15 city: AMSTERDAM postcode: 1105AZ website: www.amc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	365˙146.00
7	DANMARKS TEKNISKE UNIVERSITET DANMARKS TEKNISKE UNIVERSITET Organization address address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A city: KGS LYNGBY postcode: 2800 website: www.dtu.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KGS LYNGBY)	participant	292˙765.00
8	CEVA SANTE ANIMALE SA CEVA SANTE ANIMALE SA Organization address address: AVENUE DE LA BALLASTIERE 10 city: LIBOURNE postcode: 33500 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (LIBOURNE)	participant	150˙625.00
9	CHR. HANSEN A/S CHR. HANSEN A/S Organization address address: BOEGE ALLE 10-12 city: HOERSHOLM postcode: 2970 website: www.chr-hansen.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (HOERSHOLM)	participant	98˙125.00

Map

Project objective

Streptococcus suis is an endemic porcine disease causing causing significant economic losses to the pork meat production industry in all countries where pigs are reared on a large scale. In some countries S. suis is the primary cause of mortality and morbidity in young pigs and the most frequent reason to prescribe antibiotics of the amino-penicillin group as a preventative measure. S. suis is also a zoonotic pathogen of humans and infections reported worldwide has increased significantly in the past years. Within S. suis many different types (serotypes, genotypes, pathotypes) exist causing problems in the development of control strategies targeting all types. Asymptomatic carriage in adult pigs is common and combined with a lack of knowledge on the host-pathogen-environment interactions, are the main reasons for failure to control the endemic nature of this pathogen. The project outputs will impact on on understanding host-pathogen-environment interactions of S. suis infections through the genome sequencing of 1200-1500 S. suis isolates from representative geographic areas of the major pork producing countries and performing genome-wide-association studies with invasive disease and asymptomatic carriage. New diagnostic methods will be developed for global monitoring of infection risk and tested on case-farms. Epidemiology studies will determine risk factors for invasive S. suis disease, including the role of co-infections, and for the first time properly assess the dynamics of the disease on a representative farm. We will increase our understanding of the virulence mechanisms involved in pathogenesis including interactions of S. suis with the innate immune system. The project outputs will strengthen the evidence base for prevention and control strategies through testing of novel conserved vaccine antigens in pigs and prevention strategies based on manipulation of the microbiota and stimulation and maturation of the innate immune system.

Deliverables

List of deliverables.
Mutants constructed in selected candidate virulence genes in S. suis strains	Other	2020-03-06 18:15:24
Identification of genes required for fitness under in vivo mimicking conditions by Tn-Seq	Documents, reports	2020-03-06 18:15:24
Report on the deep analysis of the microbiota composition in healthy and S. suis-diseased piglets	Documents, reports	2020-03-06 18:15:24
Report on the â€˜cornerstoneâ€™ species that are predicted to stabilize microbial communities in healthy piglets	Documents, reports	2020-03-06 18:15:24
Sequencing of isolate collection	Other	2020-03-06 18:15:24
Public Science Event 2	Websites, patent fillings, videos etc.	2020-03-06 18:15:24
Genome database containing core genome, meta data, virulence, serotype, MLST, antibiotic resistance	Other	2020-03-06 18:15:24
Public Science Event 1	Websites, patent fillings, videos etc.	2020-03-06 18:15:24
Collection of isolates	Other	2020-03-06 18:15:24
RReport on S. suis gene expression in blood/CSF vs artificial culture media	Documents, reports	2020-03-06 18:15:24
Establishment of Project website and information share point	Websites, patent fillings, videos etc.	2020-03-06 18:15:23
Report on effects of PRRSV infection on S. suis interaction in lung slices	Documents, reports	2020-03-06 18:15:24

Take a look to the deliverables list in detail: detailed list of PIGSs deliverables.

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