Explore the words cloud of the EPiR project. It provides you a very rough idea of what is the project "EPiR" about.
The following table provides information about the project.
Coordinator |
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Organization address contact info |
Coordinator Country | Germany [DE] |
Total cost | 2˙486˙375 € |
EC max contribution | 2˙486˙375 € (100%) |
Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
Code Call | ERC-2016-ADG |
Funding Scheme | ERC-ADG |
Starting year | 2017 |
Duration (year-month-day) | from 2017-10-01 to 2022-09-30 |
Take a look of project's partnership.
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1 | LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN | DE (MUENCHEN) | coordinator | 2˙486˙375.00 |
The genetic code consists of a defined sequence of four canonical nucleosides and the sequence of these bases carries the blueprints of all life on earth. It is apparent that this sequence information alone is not sufficient to explain how a multicellular organism can establish specialized cells like the 200 known cells types of a human body. For this, a second information layer is required and since a few years, it is apparent that this information layer is strongly based on Chemistry. Histones, DNA and RNA are the target of sophisticated chemical modification, which establishes a second layer of information. This proposal aims at decoding this chemical code on RNA, specifically on messenger RNA. More than 150 chemical derivatives of RNA nucleosides are known and many more await discovery. We are proposing a program to study RNA modifications and to decipher their function. We are expecting to answer key questions about the structures, the distribution and the biological function of numerous known and yet unknown chemical RNA derivatives that brings us deep into unexplored areas of science. Since some of the modified bases equip RNA with yet unknown reactivity we will study the functional aspects of reactive bases, which allows us to tackle some of the most important questions associated with the RNA world theory. Our results will move Europe into a central position in the new field of RNA epigenetics, which has the potential to become the next big wave in science 63 years after the discovery of the double helix structure. We are perfectly positioned to move the field forward. We established quantitative methods to study modified bases that uncovered a new biological principles in cancer cells (Carell, Carmeliet, Lamberts Nature 2016) and we contributed to the RNA world theory (Carell Science 2016). We applied proteomic tools to learn about the function of new DNA bases that we partially even discovered (Carell, Vermeulen Cell 2013; Carell Nat. Chem. Biol. 2014).
year | authors and title | journal | last update |
---|---|---|---|
2019 |
Milda NainytÄ—, Tynchtyk Amatov, Thomas Carell Synthesis of an acp 3 U phosphoramidite and incorporation of the hypermodified base into RNA published pages: 12216-12218, ISSN: 1359-7345, DOI: 10.1039/c9cc06314e |
Chemical Communications 55/81 | 2020-04-04 |
2019 |
Sidney Becker, Jonas Feldmann, Stefan Wiedemann, Hidenori Okamura, Christina Schneider, Katharina Iwan, Antony Crisp, Martin Rossa, Tynchtyk Amatov, Thomas Carell Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides published pages: 76-82, ISSN: 0036-8075, DOI: 10.1126/science.aax2747 |
Science 366/6461 | 2020-04-04 |
2019 |
Michael Stadlmeier, Leander Simon Runtsch, Filipp Streshnev, Martin Wühr, Thomas Carell A Clickâ€Chemistryâ€Based Enrichable Crosslinker for Structural and Protein Interaction Analysis by Mass Spectrometry published pages: 103-107, ISSN: 1439-4227, DOI: 10.1002/cbic.201900611 |
ChemBioChem 21/1-2 | 2020-04-04 |
2019 |
Clemens Reto Dialer, Samuele Stazzoni, David Jan Drexler, Felix Moritz Müller, Simon Veth, Alexander Pichler, Hidenori Okamura, Gregor Witte, Karlâ€Peter Hopfner, Thomas Carell A Clickâ€Chemistry Linked 2′3′â€cGAMP Analogue published pages: 2089-2095, ISSN: 0947-6539, DOI: 10.1002/chem.201805409 |
Chemistry – A European Journal 25/8 | 2020-04-04 |
2020 |
Milda Nainyte, Thomas Carell Synthesis and Incorporation of k 2 U into RNA published pages: , ISSN: 0018-019X, DOI: 10.1002/hlca.202000016 |
Helvetica Chimica Acta 103/3 | 2020-04-04 |
2019 |
Wilhelm Greulich, Mirko Wagner, Moritz M. Gaidt, Che Stafford, Yiming Cheng, Andreas Linder, Thomas Carell, Veit Hornung TLR8 Is a Sensor of RNase T2 Degradation Products published pages: 1264-1275.e13, ISSN: 0092-8674, DOI: 10.1016/j.cell.2019.11.001 |
Cell 179/6 | 2020-04-04 |
2019 |
Hidenori Okamura, Antony Crisp, Sarah Hübner, Sidney Becker, Petra Rovó, Thomas Carell Protoâ€Ureaâ€RNA (Wöhler RNA) Containing Unusually Stable Urea Nucleosides published pages: 18691-18696, ISSN: 1433-7851, DOI: 10.1002/anie.201911746 |
Angewandte Chemie International Edition 58/51 | 2020-04-04 |
2020 |
Nada Raddaoui, Stefano Groce, Florian Geiger, Alexander Borodavka, Leonhard Möckl, Samuele Stazzoni, Bastien Viverge, Christoph Bräuchle, Thomas Frischmuth, Hanna Engelke, Thomas Carell Super-sensitive multi-fluorophore RNA-FISH for early virus detection and flow-FISH using click chemistry published pages: , ISSN: 1439-4227, DOI: 10.1002/cbic.202000081 |
ChemBioChem 18.03.2020 | 2020-04-04 |
2018 |
Timm T. Ensfelder, Matthias Q. Kurz, Katharina Iwan, Simon Geiger, Sarah Matheisl, Markus Müller, Roland Beckmann, Thomas Carell ALKBH5-induced demethylation of mono- and dimethylated adenosine published pages: 8591-8593, ISSN: 1359-7345, DOI: 10.1039/c8cc03980a |
Chemical Communications 54/62 | 2020-04-04 |
2020 |
Peter Thumbs, Timm T. Ensfelder, Markus Hillmeier, Mirko Wagner, Matthias Heiss, Constanze Scheel, Alexander Schön, Markus Müller, Stylianos Michalakis, Stefanie Kellner, Thomas Carell Synthesis of galactosylâ€queuosine and distribution of hypermodified Qâ€nucleosides in mouse tissues published pages: , ISSN: 1433-7851, DOI: 10.1002/anie.202002295 |
Angewandte Chemie International Edition 11.03.2020 | 2020-04-04 |
2020 |
Alexander Schön, Ewelina Kaminska, Florian Schelter, Eveliina Ponkkonen, Eva Korytiaková, Sarah Schiffers, Thomas Carell Analysis of an Active Deformylation Mechanism of 5â€Formylâ€deoxycytidine (fdC) in Stem Cells published pages: 5591-5594, ISSN: 1433-7851, DOI: 10.1002/anie.202000414 |
Angewandte Chemie International Edition 59/14 | 2020-04-04 |
2019 |
Thomas M. Wildenhof, Sarah Schiffers, Franziska R. Traube, Peter Mayer, Thomas Carell Influencing Epigenetic Information with a Hydrolytically Stable Carbocyclic 5â€Azaâ€2′â€deoxycytidine published pages: 12984-12987, ISSN: 1433-7851, DOI: 10.1002/anie.201904794 |
Angewandte Chemie International Edition 58/37 | 2020-04-04 |
2018 |
Christina Schneider, Sidney Becker, Hidenori Okamura, Antony Crisp, Tynchtyk Amatov, Michael Stadlmeier, Thomas Carell Noncanonical RNA Nucleosides as Molecular Fossils of an Early Earth-Generation by Prebiotic Methylations and Carbamoylations published pages: 5943-5946, ISSN: 1433-7851, DOI: 10.1002/anie.201801919 |
Angewandte Chemie International Edition 57/20 | 2019-06-11 |
2018 |
Sidney Becker, Christina Schneider, Antony Crisp, Thomas Carell Non-canonical nucleosides and chemistry of the emergence of life published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-07222-w |
Nature Communications 9/1 | 2019-06-11 |
2018 |
Katharina Iwan, René Rahimoff, Angie Kirchner, Fabio Spada, Arne S Schröder, Olesea Kosmatchev, Shqiponja Ferizaj, Jessica Steinbacher, Edris Parsa, Markus Müller, Thomas Carell 5-Formylcytosine to cytosine conversion by C–C bond cleavage in vivo published pages: 72-78, ISSN: 1552-4450, DOI: 10.1038/nchembio.2531 |
Nature Chemical Biology 14/1 | 2019-06-11 |
2018 |
Sidney Becker, Christina Schneider, Hidenori Okamura, Antony Crisp, Tynchtyk Amatov, Milan Dejmek, Thomas Carell Wet-dry cycles enable the parallel origin of canonical and non-canonical nucleosides by continuous synthesis published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-02639-1 |
Nature Communications 9/1 | 2019-06-11 |
2019 |
Hidenori Okamura, Sidney Becker, Niklas Tiede, Stefan Wiedemann, Jonas Feldmann, Thomas Carell A one-pot, water compatible synthesis of pyrimidine nucleobases under plausible prebiotic conditions published pages: 1939-1942, ISSN: 1359-7345, DOI: 10.1039/c8cc09435g |
Chemical Communications 55/13 | 2019-05-15 |
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The information about "EPIR" are provided by the European Opendata Portal: CORDIS opendata.
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