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RegGeneMems SIGNED

Understanding the evolution of regeneration-permissive gene expression and positional memory in Axolotl limb regeneration

Total Cost €

EC-Contrib. €

Partnership

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RegGeneMems project word cloud

Explore the words cloud of the RegGeneMems project. It provides you a very rough idea of what is the project "RegGeneMems" about.

reactivated sequences closely vertebrates genome embryonic traits positional gene molecular remarkably body dissect equally evolution situations signalling species expression memory understand refer regulatory axolotl size regeneration adult acting evo removal function trans context nature pursue vertebrate question functionally models functional form morphogens animal arose wounding vast patterns yielded critical morphogen corresponding systematic accomodate reg diverse divergent organ molecularly scaling tissue axes morphologically blastema display bud network limb resembles conserved amputation hypothesize fascinating governing revealed diverged arising specificity patterning cassettes plan diversity astounding

Project "RegGeneMems" data sheet

The following table provides information about the project.

Coordinator	FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH Organization address address: CAMPUS-VIENNA-BIOCENTER 1 city: WIEN postcode: 1030 website: www.imp.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Austria [AT]
Total cost	2˙325˙659 €
EC max contribution	2˙325˙659 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2016-ADG
Funding Scheme	ERC-ADG
Starting year	2018
Duration (year-month-day)	from 2018-01-01 to 2022-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH Organization address address: CAMPUS-VIENNA-BIOCENTER 1 city: WIEN postcode: 1030 website: www.imp.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	coordinator	2˙325˙659.00

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Project objective

Molecular studies of development in diverse animal models have revealed the remarkably conserved set of morphogens governing growth and patterning of body axes and organ fields. Equally astounding is the diversity of form and function arising from the implementation of these morphogens. The systematic analysis of well-defined traits in closely related species has revealed how changes in gene regulatory sequences and their trans-acting factors have yielded diversity. An important future challenge is to understand, at the genome level, the evolution of animal form in situations where such a rich set of closely related species may not be available.

Vertebrate limb regeneration is a particularly fascinating yet challenging context to pursue the evolution of traits related to controlling the body plan. Amputation of the Axolotl limb results in the formation of a limb blastema that morphologically and molecularly resembles the embryonic limb bud. In this system, the limb morphogen network must be reactivated only upon tissue removal and not wounding, but also corresponding to a positional memory existing in the adult tissue. These signalling cassettes must also be deployed in a way that can scale to the size of a blastema that is vast when compared to an embryonic limb bud. An important question is whether and how the limb development network has diverged to accomodate these unique traits.

During Axolotl limb development and regeneration, some key limb morphogens display divergent expression patterns compared to other vertebrates. I hypothesize that this divergent expression has functional importance for allowing limb regeneration. My goal is to 1) understand how this divergent expression arose 2) functionally test its role in regeneration specificity and scaling, and 3) use the system to dissect the molecular nature of positional memory that is critical for regeneration. I refer to this work as “evo-reg”.

Publications

List of publications.
year	authors and title	journal	last update
2018	Tobias Gerber, Prayag Murawala, Dunja Knapp, Wouter Masselink, Maritta Schuez, Sarah Hermann, Malgorzata Gac-Santel, Sergej Nowoshilow, Jorge Kageyama, Shahryar Khattak, Joshua D. Currie, J. Gray Camp, Elly M. Tanaka, Barbara Treutlein Single-cell analysis uncovers convergence of cell identities during axolotl limb regeneration published pages: eaaq0681, ISSN: 0036-8075, DOI: 10.1126/science.aaq0681	Science 362/6413	2019-08-06
2019	Wouter Masselink, Daniel Reumann, Prayag Murawala, Pawel Pasierbek, Yuka Taniguchi, FranÃ§ois Bonnay, Katharina Meixner, JÃ¼rgen A. Knoblich, Elly M. Tanaka Broad applicability of a streamlined ethyl cinnamate-based clearing procedure published pages: dev166884, ISSN: 0950-1991, DOI: 10.1242/dev.166884	Development 146/3	2019-08-29

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The information about "REGGENEMEMS" are provided by the European Opendata Portal: CORDIS opendata.