gdTCR-Ligand SIGNED
Investigating the recognition of a novel ligand by gamma-delta T cells and the translation of this interaction into molecules for future cancer immunotherapy
Total Cost €
0EC-Contrib. €
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Project "gdTCR-Ligand" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Organization address contact info |
| Coordinator Country | Netherlands [NL] |
| Project website | http://www.tumor-immunology-utrecht.nl/news/2017/3/9/eu-grant-for-dennis-beringer-group-kuball |
| Total cost | 177˙598 € |
| EC max contribution | 177˙598 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2016 |
| Funding Scheme | MSCA-IF-EF-RI |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-06-01 to 2019-05-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITAIR MEDISCH CENTRUM UTRECHT | NL (UTRECHT) | coordinator | 177˙598.00 |
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Project objective
Gamma-delta (gd-)T cells are a fast acting subset of T cells that recognize a wide variety of ligands. In contrast to alpha-beta T cells they are not restricted to classical peptide-MHC antigens. Our preliminary data on a gd-T cell clone shows selective recognition of tumour cells mediated through a novel ligand. The aims of this action are; 1) elucidating the molecular mechanism of the gd-T cell receptor (TCR) recognizing the novel ligand on cancer cells and 2) generating therapeutic agents for cancer cells. A multidisciplinary approach will be used to unveil the interaction of the gd-TCR with its ligand. The gd-TCR and novel ligand molecules will be made using recombinant expression. These proteins will be used to characterize this interaction in detail by determining the affinity and the crystal structure. The results generated in this part of the action will increase the current knowledge regarding gd-T cell ligands. The researcher will reintegrate in his home country using his skills in structural immunology, which he acquired in the Rossjohn laboratory at Monash University in Australia, to address the molecular mechanism of the gd-TCR ligand interaction. Additionally, he will be trained by the host laboratory in in vitro and in vivo immunological assays.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
G. J. J. Kierkels, W. Scheper, A. D. Meringa, I. Johanna, D. X. Beringer, A. Janssen, M. Schiffler, T. Aarts-Riemens, L. Kramer, T. Straetemans, S. Heijhuurs, J. H. W. Leusen, E. San José, K. Fuchs, M. Griffioen, J. H. Falkenburg, L. Bongiovanni, A. de Bruin, D. Vargas-Diaz, M. Altelaar, A. J. R. Heck, L. D. Shultz, F. Ishikawa, M. I. Nishimura, Z. Sebestyén, J. Kuball Identification of a tumor-specific allo-HLA–restricted γδTCR published pages: 2870-2882, ISSN: 2473-9537, DOI: 10.1182/bloodadvances.2019032409 |
Blood Advances 3/19 | 2019-10-29 |
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