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INDEX SIGNED

Integrated nanoparticle isolation and detection system for complete on-chip analysis of exosomes

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

INDEX project word cloud

Explore the words cloud of the INDEX project. It provides you a very rough idea of what is the project "INDEX" about.

diameter nanoparticles isolated phenotyping chip communication clinical index clarified technologies utility capture magnetic plasma release technically cancer breadth complete bnp nanoparticle frontiers 30nm sub detection standard multiple mediate microfluidics fluids immune valuable cells critically size isolation automated accomplished integration lung profiling diagnostics human generation bodily units detected isolate demonstrated samples paradigm purity chemistries exosome successful digital characterization small assays care exosomes unmatched molecular latitude enrichment particles revolutionizing counting extremely technological sensor once biological promise clinically breakthroughs holds efficient

Project "INDEX" data sheet

The following table provides information about the project.

Coordinator	CONSIGLIO NAZIONALE DELLE RICERCHE Organization address address: PIAZZALE ALDO MORO 7 city: ROMA postcode: 185 website: www.cnr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Project website	http://www.indexproject.eu/
Total cost	2˙983˙525 €
EC max contribution	2˙982˙275 € (100%)
Programme	1. H2020-EU.1.2.1. (FET Open)
Code Call	H2020-FETOPEN-1-2016-2017
Funding Scheme	RIA
Starting year	2017
Duration (year-month-day)	from 2017-10-01 to 2020-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	CONSIGLIO NAZIONALE DELLE RICERCHE CONSIGLIO NAZIONALE DELLE RICERCHE Organization address address: PIAZZALE ALDO MORO 7 city: ROMA postcode: 185 website: www.cnr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	coordinator	758˙750.00
2	THE TRUSTEES OF BOSTON UNIVERSITY THE TRUSTEES OF BOSTON UNIVERSITY Organization address address: COMMONWEALTH AVENUE 881 city: BOSTON MA postcode: 2215 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (BOSTON MA)	participant	708˙500.00
3	INSTITUT CURIE INSTITUT CURIE Organization address address: rue d'Ulm 26 city: PARIS postcode: 75231 website: www.curie.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	516˙162.00
4	FLUIGENT SA FLUIGENT SA Organization address address: 57-77 AVENUE DE FONTAINEBLEAU city: LE KREMLIN-BICETRE postcode: 94270 website: www.fluigent.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (LE KREMLIN-BICETRE)	participant	473˙862.00
5	REGION NORDJYLLAND (NORTH DENMARK REGION) REGION NORDJYLLAND (NORTH DENMARK REGION) Organization address address: Niels Bohrs Vej 30 city: AALBORG postcode: 9220 website: www.rn.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (AALBORG)	participant	310˙000.00
6	HANSABIOMED LIFE SCIENCES OU HANSABIOMED LIFE SCIENCES OU Organization address address: AKADEEMIA TEE 15A city: TALLINN postcode: 12618 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EE (TALLINN)	participant	215˙000.00

Map

Project objective

The aim of Project INDEX is to isolate and characterize nanoparticles available in bodily fluids through development and integration of novel technological breakthroughs. The technology will enable the analysis of clinically valuable nanoparticles called exosomes towards new generation diagnostics. Exosomes are known to mediate communication between cells and their effective utilization holds a great promise of revolutionizing the standard of clinical care. However, their detection and molecular profiling is technically challenging. The proposed technology will isolate exosomes that are as small as 30nm in diameter from human plasma with high purity, and provide in-depth, multi-parameter characterization of the particles through digital counting, size determination, and biological phenotyping. Towards this goal: (1) Novel microfluidics will be developed and used for efficient magnetic enrichment; (2) Isolated particles will be detected and analyzed with a novel biological nanoparticle (BNP) sensor (3) Immune-capture and release chemistries as well as phenotyping assays will be developed; (4) Critically, complete on-chip integration of isolation, detection and analysis will be accomplished; (5) Utility of in-depth exosome characterization will be demonstrated with clinical samples for lung cancer. Project INDEX requires successful integration of multiple sub-units and assays that each represents technological frontiers, which is extremely challenging. However, the breadth of information on exosomes that will be available with the integrated system is unmatched. Although, the clinical utility of exosomes is still developing, the uncertainty can only be clarified through automated technologies that provide latitude of information. Once completed, Project INDEX can demonstrate a new paradigm in cancer diagnostics, and also present a potential future technology for other applications involving nanoparticles.

Deliverables

List of deliverables.
Data management plan	Open Research Data Pilot	2020-04-09 11:31:55
Report on exosome-specific Ab selection	Documents, reports	2020-04-09 11:31:55
Report on criteria for system demonstration	Documents, reports	2020-04-09 11:31:55
Project dedicated web site	Websites, patent fillings, videos etc.	2020-04-09 11:31:55

Take a look to the deliverables list in detail: detailed list of INDEX deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Chiodi, Elisa; Sola, Laura; Brambilla, Dario; Cretich, Marina; Marn, Allison; ÃœnlÃ¼, M. Selim; et al. Simultaneous Evaluation of Multiple Microarray Surface Chemistries Through Real-Time Interferometric Imaging. published pages: , ISSN: , DOI: 10.26434/chemrxiv.8976347.v1	Chemrxiv	2020-04-09
2019	Gori, Alessandro; Romanato, Alessandro; Bergamaschi, Greta; Strada, Alessandro; Gagni, Paola; Frigerio, Roberto; et al. Membrane-Binding Peptides for Extracellular Vesicles On-Chip Analysis published pages: , ISSN: , DOI: 10.26434/chemrxiv.9885167.v1	Chmrxiv	2020-04-09
2018	Francesco Damin, Silvia Galbiati, Nadia Soriani, Valentina Burgio, Monica Ronzoni, Maurizio Ferrari, Marcella Chiari Analysis of KRAS, NRAS and BRAF mutational profile by combination of in-tube hybridization and universal tag-microarray in tumor tissue and plasma of colorectal cancer patients published pages: e0207876, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0207876	PLOS ONE 13/12	2020-04-09

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Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

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The information about "INDEX" are provided by the European Opendata Portal: CORDIS opendata.