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HybridHeart SIGNED

Development of the first fully biocompatible, soft actuated heart: combining in situ tissue engineering and soft robotics

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

HybridHeart project word cloud

Explore the words cloud of the HybridHeart project. It provides you a very rough idea of what is the project "HybridHeart" about.

transfer million replacing limbs off lining cardiac form causes bioinspired either engineering worldwide procedure tech adaptable vessels power parallel structures contacting clinic chronic surfaces natural wireless shelf motion valves lung bowel muscles underlying severe model organ situ heart biocompatibility robotics te hemocompatible full envisions scaffolds smes replace mechanical hybrid patients patient biocompatible components organs permanent interdisciplinary soft first applicable entire shell receive source stage 23 completely actuators surgery blood group artificial cure external bio made shown inner muscle transplant sensors people sheep complications academic consist elastomeric robotic circulatory therapy tissue proof energy containing

Project "HybridHeart" data sheet

The following table provides information about the project.

Coordinator	ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Organization address address: MEIBERGDREEF 15 city: AMSTERDAM postcode: 1105AZ website: www.amc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	http://www.hybridheart.eu
Total cost	3˙035˙550 €
EC max contribution	3˙035˙550 € (100%)
Programme	1. H2020-EU.1.2.1. (FET Open)
Code Call	H2020-FETOPEN-1-2016-2017
Funding Scheme	RIA
Starting year	2017
Duration (year-month-day)	from 2017-11-01 to 2022-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Organization address address: MEIBERGDREEF 15 city: AMSTERDAM postcode: 1105AZ website: www.amc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	coordinator	705˙000.00
2	TECHNISCHE UNIVERSITEIT EINDHOVEN TECHNISCHE UNIVERSITEIT EINDHOVEN Organization address address: GROENE LOPER 3 city: EINDHOVEN postcode: 5612 AE website: www.tue.nl/en contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (EINDHOVEN)	participant	585˙000.00
3	SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO S ANNA SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO S ANNA Organization address address: PIAZZA MARTIRI DELLA LIBERTA 33 city: PISA postcode: 56127 website: www.sssup.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (PISA)	participant	454˙375.00
4	XELTIS BV XELTIS BV Organization address address: DE LISMORTEL R2 06 CAT BUILD 31 city: EINDHOVEN postcode: 5612 AR website: www.qtis.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (EINDHOVEN)	participant	443˙675.00
5	STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN Organization address address: WINTHONTLAAN 2 city: UTRECHT postcode: 3526 KV website: www.fom.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	participant	396˙250.00
6	EM-TEC GMBH WERNER HEINZE EM-TEC GMBH WERNER HEINZE Organization address address: LERCHENBERG 20 city: FINNING postcode: 86932 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (FINNING)	participant	311˙145.00
7	DUALIS MEDTECH GMBH DUALIS MEDTECH GMBH Organization address address: AM TECHNOLOGIEPARK 8+10 city: SEEFELD postcode: 82229 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (SEEFELD)	participant	140˙104.00

Map

Project objective

The Hybrid Heart consortium envisions to develop and bring to the clinic soft biocompatible artificial organs. These will consist of a soft robotics shell with actuators (‘artificial muscles’) and sensors, enabling completely natural motion. The inner lining and structures will be made by in situ tissue engineering (TE), ensuring biocompatibility of blood-contacting surfaces. As the first step, the consortium will develop the Hybrid Heart, which can completely replace a patient’s heart in a procedure similar to a heart transplant, to provide a cure for heart failure, which affects ~23 million people worldwide. Currently, patients with end-stage heart failure either receive a heart transplant, if available, or long-term mechanical circulatory support, which causes severe complications. To achieve the ambitious goal of providing a permanent cure for these patients, the participants will, in parallel, develop the components of the Hybrid Heart: 1) a soft elastomeric robotics shell containing actuators and sensors, 2) scaffolds for in situ TE of inner lining, valves and vessels and 3) a wireless energy transfer system. These components together will form the full Hybrid Heart, which will be soft, adaptable, wireless and fully bio- and hemocompatible. Both functionality as well as biocompatibility of the Hybrid Heart will be shown in a Proof-of-Principle study in the chronic sheep model at the end of the project. The Hybrid Heart project will be carried out by an interdisciplinary group of (academic) researchers and high-tech SMEs, with experience in cardiac surgery, TE, soft robotics and engineering. The technology underlying the Hybrid Heart is applicable to a range of soft robotics-based artificial organs, including the bowel, lung, or muscle structures (limbs). Replacing an entire organ with bioinspired robotic elements, TE biocompatible surfaces, artificial sensors, and an external power source allows for an off-the-shelf therapy for patients with organ failure.

Deliverables

List of deliverables.
Data Management Plan	Open Research Data Pilot	2019-09-04 15:59:05
Cross-institutional knowledge exchange: TE scaffolds and matrix polymers	Other	2019-09-04 15:59:05
Whitepaper on requirements and constraints of combining technologies	Documents, reports	2019-09-04 15:59:04
Website and logo	Websites, patent fillings, videos etc.	2019-09-04 15:59:04

Take a look to the deliverables list in detail: detailed list of HybridHeart deliverables.

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The information about "HYBRIDHEART" are provided by the European Opendata Portal: CORDIS opendata.