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EU-TRAIN SIGNED

The EUropean TRAnsplantation and INnovation (EU-TRAIN) consortium for improving diagnosis and risk stratification in kidney transplant patients

Total Cost €

EC-Contrib. €

Partnership

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EU-TRAIN project word cloud

Explore the words cloud of the EU-TRAIN project. It provides you a very rough idea of what is the project "EU-TRAIN" about.

randomised 12 centres industrial outcomes biomarker clinicians data reference transplantation realistic gathering risk evaluator train prediction formed personalise patients gene innovative invasive web allograft tracer diffusion immunological care trials society decision assist accessible prognostic individual treatment patient translation biomarkers histological immune transplant dramatic network expression recipients mortality validated graft engineer clinical integration lacks analysing monitoring trial multiplex interactive goals suitable delivering rejection kidney impairs standard interface morbidity stratification tools layers

Project "EU-TRAIN" data sheet

The following table provides information about the project.

Coordinator	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Total cost	6˙641˙546 €
EC max contribution	6˙641˙546 € (100%)
Programme	1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
Code Call	H2020-SC1-2017-Two-Stage-RTD
Funding Scheme	RIA
Starting year	2018
Duration (year-month-day)	from 2018-01-01 to 2022-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	coordinator	1˙025˙447.00
2	CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES Organization address address: Allee de l'Ile Gloriette 5 city: NANTES postcode: 44093 website: www.chu-nantes.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (NANTES)	participant	1˙207˙741.00
3	ASSISTANCE PUBLIQUE HOPITAUX DE PARIS ASSISTANCE PUBLIQUE HOPITAUX DE PARIS Organization address address: 3 AVENUE VICTORIA city: PARIS postcode: 75000 website: http://www.aphp.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	1˙154˙520.00
4	CHARITE - UNIVERSITAETSMEDIZIN BERLIN CHARITE - UNIVERSITAETSMEDIZIN BERLIN Organization address address: Chariteplatz 1 city: BERLIN postcode: 10117 website: www.charite.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	participant	898˙236.00
5	INSTITUT CATALA DE LA SALUT INSTITUT CATALA DE LA SALUT Organization address address: GRAN VIA DE LES CORTS CATALANES 587 city: BARCELONA postcode: 8007 website: http://www.gencat.cat/ics/germanstrias/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	750˙597.00
6	UNIVERSITE DE GENEVE UNIVERSITE DE GENEVE Organization address address: RUE DU GENERAL DUFOUR 24 city: GENEVE postcode: 1211 website: www.unige.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (GENEVE)	participant	444˙413.00
7	INSERM TRANSFERT SA INSERM TRANSFERT SA Organization address address: RUE WATT 7 city: PARIS postcode: 75013 website: www.inserm-transfert.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	391˙875.00
8	OXFORD IMMUNOTEC LIMITED OXFORD IMMUNOTEC LIMITED Organization address address: 94C INNOVATION DRIVE, MILTON PARK OXFORDSHIRE city: ABINGDON postcode: OX14 4RZ website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (ABINGDON)	participant	303˙841.00
9	CELLTREND GESELLSCHAFT MIT BESCHRANKTER HAFTUNG CELLTREND GESELLSCHAFT MIT BESCHRANKTER HAFTUNG Organization address address: IM BIOTECHNOLOGIEPARK TGZ II city: LUCKENWALDE postcode: 14943 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (LUCKENWALDE)	participant	208˙313.00
10	EUROPEAN SOCIETY FOR ORGAN TRANSPLANTATION EUROPEAN SOCIETY FOR ORGAN TRANSPLANTATION Organization address address: WESTERDOKSDIJK 423 city: AMSTERDAM postcode: 1013 BX website: www.esot.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	120˙000.00
11	CERNER FRANCE CERNER FRANCE Organization address address: 5 PLACE DE LA PYRAMIDE, TOUR ARIANE city: PUTEAUX postcode: 92800 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PUTEAUX)	participant	96˙563.00
12	ECRIN EUROPEAN CLINICAL RESEARCH INFRASTRUCTURE NETWORK ECRIN EUROPEAN CLINICAL RESEARCH INFRASTRUCTURE NETWORK Organization address address: 5 RUE WATT city: PARIS postcode: 75013 website: www.ecrin.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	40˙000.00

Map

Project objective

Rejection is the major cause of allograft failure with dramatic consequences in terms of mortality, morbidity and increased cost for the society. The field of transplantation lacks a robust assessment of risk stratification. Thus, it impairs the development of relevant clinical trials to address graft and patient outcomes. We formed the EU-TRAIN project by gathering reference kidney transplant centres in a fully operating European network including 12 partners. Our ambitious but realistic goals are: to provide clinicians with innovative and accessible tools for early prediction of individual risk of allograft rejection and transplant loss; to personalise clinical management and treatment and; to improve allograft outcomes. This project will engineer a risk stratification system applied to kidney transplant patients by analysing the integration of several layers of data (clinical, histological, immunological data as well as gene expression and novel biomarkers) - the TRAnsplant Comprehensive Evaluator of Risk (EU-TRACER). EU-TRACER will be generated and validated in 2 dedicated studies including a randomised control trial. Translation to patients will be achieved by delivering: 1) A multiplex non-invasive biomarker system for the stratification and immune monitoring of low and high risk kidney recipients; 2) A prognostic system for individual risk stratification for allograft rejection and failure that will assist decision making via an interactive web interface. The EU-TRACER, developed with our 3 industrial partners, will define a new standard of care in transplantation. The EU-TRACER will have the potential for a large implementation and diffusion in other centres in Europe and will be suitable for industrial collaboration.

Deliverables

List of deliverables.
Communication and Dissemination tools	Websites, patent fillings, videos etc.	2020-04-07 22:49:49

Take a look to the deliverables list in detail: detailed list of EU-TRAIN deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Nuria Montero, Samira Farouk, Ilaria Gandolfini, Elena Crespo, Marta Jarque, Maria Meneghini, Alba Torija, Umberto Maggiore, Paolo Cravedi, Oriol Bestard Pretransplant Donor-specific IFNÎ³ ELISPOT as a Predictor of Graft Rejection published pages: e451, ISSN: 2373-8731, DOI: 10.1097/txd.0000000000000886	Transplantation Direct 5/5	2020-04-07

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The information about "EU-TRAIN" are provided by the European Opendata Portal: CORDIS opendata.