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ITHACA

Immuno-targeting of human AML quiescent cells by a novel phage display approach.

Total Cost €

EC-Contrib. €

Partnership

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ITHACA project word cloud

Explore the words cloud of the ITHACA project. It provides you a very rough idea of what is the project "ITHACA" about.

aml usually antibodies cheap critical aggressive model erc identification onset leukemic cells accompanied leukaemia intellectual competition therapeutic indirectly amls primary antibody maintenance followed platform performed human chemotherapy quick acute cloning vivo relapse hypothesis phage die xenotransplantation frequently later fatal mouse plan resistant treatment relative confirm recombinant disease ttfactor generate myeloid patient fuel majority one selectively inmec either remission notably tumour malignancy proliferating candidate stem commercial promotion business ngs screening display grant suggest recognize patients proliferative procedure innovative versus treatments validation quiescent market cell sensitive 341131 isolate unprecedented property cancer hematologic cscs

Project "ITHACA" data sheet

The following table provides information about the project.

Coordinator	ISTITUTO EUROPEO DI ONCOLOGIA SRL Organization address address: Via Filodrammatici 10 city: MILANO postcode: 20121 website: www.ieo.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Total cost	150˙000 €
EC max contribution	150˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-PoC
Funding Scheme	ERC-POC
Starting year	2018
Duration (year-month-day)	from 2018-01-01 to 2019-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ISTITUTO EUROPEO DI ONCOLOGIA SRL ISTITUTO EUROPEO DI ONCOLOGIA SRL Organization address address: Via Filodrammatici 10 city: MILANO postcode: 20121 website: www.ieo.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	coordinator	150˙000.00

Map

Project objective

One main objective of our ERC Advanced Grant project (InMec, No 341131) was to determine how cancer stem cells (CSCs) contribute to tumour growth, and the relative impact of quiescent versus proliferative CSCs. In Acute Myeloid Leukaemia (AML), our results strongly suggest that quiescent leukaemia stem cells are critical for leukaemia maintenance and relapse after treatments. AML is an aggressive and frequently fatal hematologic malignancy. It is usually sensitive to chemotherapy at its onset, leading to disease remission in most patients; however, the majority of patient will later relapse and eventually die. Notably, leukaemia stem cells are often resistant to chemotherapy. We will use our innovative phage-display antibody screening platform to generate antibodies against AMLs. The screening will be performed directly on human AMLs growing in vivo, using an innovative mouse xenotransplantation model followed by an NGS-based antibody selection procedure. We plan to isolate antibodies that selectively recognize leukaemia stem cells, either quiescent or proliferating. Our primary goal is to develop novel therapeutic antibodies for the treatment of AMLs. This project will also indirectly confirm the hypothesis that leukaemia stem cells are the real fuel of the disease. We expect that this project will lead to quick and cheap identification, cloning and validation of human recombinant antibodies towards against AML leukemic stem cells. The use of phage display technology to isolate leukemic stem cell-specific human recombinant antibodies is to our knowledge unprecedented. The development of candidate antibodies against AMLs will be accompanied by the promotion of commercial/exploitation activities such as market and competition analyses, intellectual property management, and product and business development through the activities of our partner TTFactor.

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The information about "ITHACA" are provided by the European Opendata Portal: CORDIS opendata.