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MicroAdiPSChip SIGNED

Micro-Fat Tissue on Chip

Total Cost €

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EC-Contrib. €

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Partnership

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 MicroAdiPSChip project word cloud

Explore the words cloud of the MicroAdiPSChip project. It provides you a very rough idea of what is the project "MicroAdiPSChip" about.

expansion    reserve    cell    exploited    data    fat    chemical    resolution    mechanical    tissue    clinically    disorders    times    situ    energy    treatments    treat    single    integration    lack    whereas    differentiate    recapitulating    technologies    cures    heat    micrometers    diabetes    divided    cells    natural    niches    micro    hipscs    microenvironmental    intake    dynamically    exposure    platforms    brown    burn    mechanistically    active    obstacles    store    stem    longer    detection    restore    metabolic    pluripotent    induce    architectural    niche    experimental    strategy    laboratory    imbalance    organisms    mobilize    cold    tissues    incorporated    leads    adipose    assembly    outside    obesity    bioprinting    beige    reveal    activate    serve    simulate    microenvironment    differentiation    maintenance    clinical    sizes    white    adipocytes    metabolically    models    mature    understand    inducible    human    patient    attractive    expenditure    combine    chip    microfluidic    nbsp    subtypes    acquired    generate    of   

Project "MicroAdiPSChip" data sheet

The following table provides information about the project.

Coordinator		 HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH 

Organization address
address: INGOLSTADTER LANDSTRASSE 1
city: NEUHERBERG
postcode: 85764
website: www.helmholtz-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Germany [DE]
 Total cost 1˙775˙000 €
 EC max contribution 1˙775˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2023-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH DE (NEUHERBERG) coordinator 1˙775˙000.00

Map

 Project objective

Human fat tissue has evolved to serve as a major energy reserve. An imbalance between energy intake and expenditure leads to an expansion of adipose tissue. Maintenance of this energy imbalance over longer times leads to obesity and metabolic disorders such as type 2 diabetes, for which clinical cures are not yet available. Adipocytes are the main cell type within the adipose tissue and can be divided into white, beige, and brown subtypes. White adipocytes store and mobilize energy, whereas beige and brown adipocytes store and burn energy during cold exposure to generate heat. An attractive strategy to restore the energy imbalance and treat obesity is to activate or increase the number of beige adipocytes in white adipose tissue. The main research obstacles affecting our ability to induce beige adipocytes is our lack of laboratory test systems recapitulating the microenvironmental conditions of the adipose tissue. Therefore, this research project aims to develop adipose tissue models outside organisms in sizes of micrometers for studying the differentiation of human inducible pluripotent stem cells (hiPSCs) into mature adipocytes. For assembly of the micro-fat tissues, we combine microfluidic and bioprinting technologies. In particular, the integration of micro-fat tissue on microfluidic chip platforms will be exploited to dynamically control the chemical, cell architectural, and mechanical microenvironment of hiPSCs incorporated in the micro-fat tissue. With novel single-cell-resolution in situ detection systems, we will aim to reveal, which microenvironmental stem cell niche factors are required to differentiate hiPSCs into metabolically active beige adipocytes. The acquired experimental data will help to mechanistically understand the role of natural stem cell niches, determine how to simulate them under laboratory conditions and finally provide patient-specific, clinically relevant information for developing new cell-based treatments for obesity.

 Publications

year authors and title journal last update
List of publications.
2020 Julius Wiener, Daniel Kokotek, Simon Rosowski, Heiko Lickert, Matthias Meier
Preparation of single- and double-oligonucleotide antibody conjugates and their application for protein analytics
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-020-58238-6 		Scientific Reports 10/1 2020-02-05

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The information about "MICROADIPSCHIP" are provided by the European Opendata Portal: CORDIS opendata.

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