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SUPERMIN SIGNED

Correlative Super Resolution Imaging of the Collagen Mineralization Process

Total Cost €

EC-Contrib. €

Partnership

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SUPERMIN project word cloud

Explore the words cloud of the SUPERMIN project. It provides you a very rough idea of what is the project "SUPERMIN" about.

proteins correlative details interactions really situ living preparation native resolution highest inorganic close engineering multiple ultrathin ehlers despite components bone imaging crystals vitro collagenous hierarchical collagen mechanical syndrome scales organic hydroxyapatite matrix relied body altering stages relatively door structural transmission happens necessarily material defects length mainly unprecedented danlos treatments simplified roles ncps understand microscopy arise cryogenic bodies super impressive electron dynamics directing produces environment editing platform mechanisms tissue provides mineralization occurs human composite lack mineralized gene organization diseases respective imperfecta carbonated significantly osteogenesis me aligned little protection

Project "SUPERMIN" data sheet

The following table provides information about the project.

Coordinator	STICHTING KATHOLIEKE UNIVERSITEIT Organization address address: GEERT GROOTEPLEIN NOORD 9 city: NIJMEGEN postcode: 6525 EZ website: www.radboudumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Total cost	165˙598 €
EC max contribution	165˙598 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2017
Funding Scheme	MSCA-IF-EF-ST
Starting year	2018
Duration (year-month-day)	from 2018-03-01 to 2020-02-29

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	STICHTING KATHOLIEKE UNIVERSITEIT STICHTING KATHOLIEKE UNIVERSITEIT Organization address address: GEERT GROOTEPLEIN NOORD 9 city: NIJMEGEN postcode: 6525 EZ website: www.radboudumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (NIJMEGEN)	coordinator	48˙299.00
2	TECHNISCHE UNIVERSITEIT EINDHOVEN TECHNISCHE UNIVERSITEIT EINDHOVEN Organization address address: GROENE LOPER 3 city: EINDHOVEN postcode: 5612 AE website: www.tue.nl/en contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (EINDHOVEN)	participant	117˙299.00

Map

Project objective

Bone tissue is an organic-inorganic composite material that provides the mechanical support and protection for our bodies. Its impressive mechanical properties arise from the hierarchical organization of the organic collagen matrix that is mineralized with ultrathin, aligned inorganic crystals of carbonated hydroxyapatite. Despite its importance to the human body, still relatively little is understood about the mechanisms by which collagen mineralization occurs, and what the respective roles are of the collagen and other, non-collagenous proteins (NCPs) in directing this process. This is because the process is complex: there are different stages that occur over multiple length scales, and many different components are involved. So far, studying collagen mineralization has mainly relied on analyses that require sample-altering preparation methods and lack information about the dynamics; or on simplified in vitro systems that do not necessarily represent what happens in the native bone environment. To really understand the role of NCPs in collagen mineralization, we need to study their dynamics and structural interactions with the highest possible resolution and in an environment as close as possible to native bone. I will use a recently developed tissue engineering platform that produces mineralized collagen with the main characteristics of that in bone. This will now allow me to apply gene editing for studying the role of NCPs in situ and in a living system with correlative imaging using super resolution microscopy and cryogenic transmission electron microscopy. My approach will provide unprecedented details on the role of selected NCPs in collagen mineralization. It will significantly impact how bone defects and mineralization are studied, and open the door to new treatments for related diseases such as osteogenesis imperfecta and Ehlers-Danlos syndrome.

Publications

List of publications.
year	authors and title	journal	last update
2019	Bregje W.M. de Wildt, Sana Ansari, Nico A.J.M. Sommerdijk, Keita Ito, Anat Akiva, Sandra Hofmann From bone regeneration to three-dimensional inÂ vitro models: tissue engineering of organized bone extracellular matrix published pages: 107-115, ISSN: 2468-4511, DOI: 10.1016/j.cobme.2019.05.005	Current Opinion in Biomedical Engineering 10	2020-04-03

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The information about "SUPERMIN" are provided by the European Opendata Portal: CORDIS opendata.