Opendata, web and dolomites

Acclimatize SIGNED

Hypothalamic mechanisms of thermal homeostasis and adaptation

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 Acclimatize project word cloud

Explore the words cloud of the Acclimatize project. It provides you a very rough idea of what is the project "Acclimatize" about.

deg    melastatin    neuronal    optogenetic    mediate    detects    area    integrates    function    conversely    close    sensitive    fortifies    slice    central    thought    adaptive    body    neuron    first    receptor    imaging    thermostat    cell    balancing    transient    37    channel    vivo    treat    local    cellular    orchestrate    brain    thermo    acclimation    harnessed    metabolic    balance    tcore    trpm2    intricate    poa    despite    energy    manipulate    mechanisms    ion    counter    ex    internal    neurons    probe    question    logic    mapping    circuits    thermogenesis    therapeutically    largely    beneficial    neural    marker    organisms    circuit    circuitry    gain    plasticity    connections    underlying    counteract    mammalian    environmental    molecular    centre    effect    suggesting    sensor    ultimately    remarkable    thermoregulatory    obesity    possess    made    preoptic    fuel    uncover    variations    peripheral    unknown    stimulation    combining    temperature    medical    electrophysiology    multidisciplinary    syndrome    maladaptive    thermal    hypothalamic    narrow   

Project "Acclimatize" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITATSKLINIKUM HEIDELBERG 

Organization address
address: IM NEUENHEIMER FELD 672
city: HEIDELBERG
postcode: 69120
website: www.klinikum.uni-heidelberg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙902˙500 €
 EC max contribution 1˙902˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITATSKLINIKUM HEIDELBERG DE (HEIDELBERG) coordinator 1˙902˙500.00

Map

 Project objective

Mammalian organisms possess the remarkable ability to maintain internal body temperature (Tcore) within a narrow range close to 37°C despite wide environmental temperature variations. The brain’s neural “thermostat” is made up by central circuits in the hypothalamic preoptic area (POA), which orchestrate peripheral thermoregulatory responses to maintain Tcore. Thermogenesis requires metabolic fuel, suggesting intricate connections between the thermoregulatory centre and hypothalamic circuits controlling energy balance. How the POA detects and integrates temperature and metabolic information to achieve thermal balance is largely unknown. A major question is whether this circuitry could be harnessed therapeutically to treat obesity. We have recently identified the first known molecular temperature sensor in thermoregulatory neurons of the POA, transient receptor potential melastatin 2 (TRPM2), a thermo-sensitive ion channel. I aim to use TRPM2 as a molecular marker to gain access to and probe the function of thermoregulatory neurons in vivo. I propose a multidisciplinary approach, combining local, in vivo POA temperature stimulation with optogenetic circuit-mapping to uncover the molecular and cellular logic of the hypothalamic thermoregulatory centre and to assess its medical potential to counteract metabolic syndrome. Acclimation is a beneficial adaptive process that fortifies thermal responses upon environmental temperature challenges. Thermoregulatory neuron plasticity is thought to mediate acclimation. Conversely, maladaptive thermoregulatory changes affect obesity. The cell-type-specific neuronal plasticity mechanisms underlying these changes within the POA, however, are unknown. Using ex-vivo slice electrophysiology and in vivo imaging, I propose to characterize acclimation- and obesity-induced plasticity of thermoregulatory neurons. Ultimately, I aim to manipulate thermoregulatory neuron plasticity to test its potential counter-balancing effect on obesity.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ACCLIMATIZE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ACCLIMATIZE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

PLAT_ACE (2019)

A new platform technology for the on-demand access to large acenes

Read More  

Resonances (2019)

Resonances and Zeta Functions in Smooth Ergodic Theory and Geometry

Read More  

SoftHandler (2019)

Commercial feasibility of an integrated soft robotic system for industrial handling

Read More