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Acclimatize SIGNED

Hypothalamic mechanisms of thermal homeostasis and adaptation

Total Cost €

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EC-Contrib. €

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Partnership

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 Acclimatize project word cloud

Explore the words cloud of the Acclimatize project. It provides you a very rough idea of what is the project "Acclimatize" about.

made    stimulation    multidisciplinary    detects    mechanisms    hypothalamic    therapeutically    largely    beneficial    tcore    preoptic    syndrome    transient    first    treat    electrophysiology    close    vivo    molecular    counteract    ultimately    channel    obesity    ex    imaging    thermogenesis    temperature    slice    local    maladaptive    narrow    balancing    intricate    suggesting    underlying    variations    gain    unknown    area    energy    balance    remarkable    plasticity    marker    uncover    organisms    melastatin    ion    thermoregulatory    fortifies    integrates    centre    function    circuit    peripheral    fuel    logic    probe    internal    cellular    possess    circuitry    thermo    optogenetic    question    connections    acclimation    medical    thought    combining    sensitive    despite    thermostat    receptor    mammalian    environmental    metabolic    neuronal    central    adaptive    body    deg    cell    mapping    neurons    circuits    thermal    brain    conversely    manipulate    orchestrate    trpm2    mediate    neural    sensor    harnessed    poa    neuron    37    effect    counter   

Project "Acclimatize" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITATSKLINIKUM HEIDELBERG 

Organization address
address: IM NEUENHEIMER FELD 672
city: HEIDELBERG
postcode: 69120
website: www.klinikum.uni-heidelberg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙902˙500 €
 EC max contribution 1˙902˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITATSKLINIKUM HEIDELBERG DE (HEIDELBERG) coordinator 1˙902˙500.00

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 Project objective

Mammalian organisms possess the remarkable ability to maintain internal body temperature (Tcore) within a narrow range close to 37°C despite wide environmental temperature variations. The brain’s neural “thermostat” is made up by central circuits in the hypothalamic preoptic area (POA), which orchestrate peripheral thermoregulatory responses to maintain Tcore. Thermogenesis requires metabolic fuel, suggesting intricate connections between the thermoregulatory centre and hypothalamic circuits controlling energy balance. How the POA detects and integrates temperature and metabolic information to achieve thermal balance is largely unknown. A major question is whether this circuitry could be harnessed therapeutically to treat obesity. We have recently identified the first known molecular temperature sensor in thermoregulatory neurons of the POA, transient receptor potential melastatin 2 (TRPM2), a thermo-sensitive ion channel. I aim to use TRPM2 as a molecular marker to gain access to and probe the function of thermoregulatory neurons in vivo. I propose a multidisciplinary approach, combining local, in vivo POA temperature stimulation with optogenetic circuit-mapping to uncover the molecular and cellular logic of the hypothalamic thermoregulatory centre and to assess its medical potential to counteract metabolic syndrome. Acclimation is a beneficial adaptive process that fortifies thermal responses upon environmental temperature challenges. Thermoregulatory neuron plasticity is thought to mediate acclimation. Conversely, maladaptive thermoregulatory changes affect obesity. The cell-type-specific neuronal plasticity mechanisms underlying these changes within the POA, however, are unknown. Using ex-vivo slice electrophysiology and in vivo imaging, I propose to characterize acclimation- and obesity-induced plasticity of thermoregulatory neurons. Ultimately, I aim to manipulate thermoregulatory neuron plasticity to test its potential counter-balancing effect on obesity.

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