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Acclimatize SIGNED

Hypothalamic mechanisms of thermal homeostasis and adaptation

Total Cost €

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EC-Contrib. €

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Partnership

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 Acclimatize project word cloud

Explore the words cloud of the Acclimatize project. It provides you a very rough idea of what is the project "Acclimatize" about.

question    function    neuron    energy    molecular    ultimately    beneficial    ion    obesity    temperature    thermal    37    despite    acclimation    fortifies    syndrome    neuronal    gain    sensor    fuel    channel    circuit    suggesting    conversely    circuitry    local    electrophysiology    body    slice    unknown    counteract    environmental    mammalian    first    trpm2    treat    thought    balancing    multidisciplinary    mechanisms    adaptive    effect    narrow    thermoregulatory    receptor    metabolic    maladaptive    stimulation    variations    made    uncover    integrates    sensitive    possess    intricate    cell    counter    balance    underlying    remarkable    imaging    therapeutically    largely    brain    mediate    harnessed    ex    internal    deg    circuits    mapping    manipulate    neurons    marker    preoptic    combining    orchestrate    area    connections    thermogenesis    organisms    melastatin    close    tcore    plasticity    neural    detects    centre    vivo    hypothalamic    probe    medical    central    transient    thermostat    thermo    poa    optogenetic    logic    cellular    peripheral   

Project "Acclimatize" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITATSKLINIKUM HEIDELBERG 

Organization address
address: IM NEUENHEIMER FELD 672
city: HEIDELBERG
postcode: 69120
website: www.klinikum.uni-heidelberg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙902˙500 €
 EC max contribution 1˙902˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITATSKLINIKUM HEIDELBERG DE (HEIDELBERG) coordinator 1˙902˙500.00

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 Project objective

Mammalian organisms possess the remarkable ability to maintain internal body temperature (Tcore) within a narrow range close to 37°C despite wide environmental temperature variations. The brain’s neural “thermostat” is made up by central circuits in the hypothalamic preoptic area (POA), which orchestrate peripheral thermoregulatory responses to maintain Tcore. Thermogenesis requires metabolic fuel, suggesting intricate connections between the thermoregulatory centre and hypothalamic circuits controlling energy balance. How the POA detects and integrates temperature and metabolic information to achieve thermal balance is largely unknown. A major question is whether this circuitry could be harnessed therapeutically to treat obesity. We have recently identified the first known molecular temperature sensor in thermoregulatory neurons of the POA, transient receptor potential melastatin 2 (TRPM2), a thermo-sensitive ion channel. I aim to use TRPM2 as a molecular marker to gain access to and probe the function of thermoregulatory neurons in vivo. I propose a multidisciplinary approach, combining local, in vivo POA temperature stimulation with optogenetic circuit-mapping to uncover the molecular and cellular logic of the hypothalamic thermoregulatory centre and to assess its medical potential to counteract metabolic syndrome. Acclimation is a beneficial adaptive process that fortifies thermal responses upon environmental temperature challenges. Thermoregulatory neuron plasticity is thought to mediate acclimation. Conversely, maladaptive thermoregulatory changes affect obesity. The cell-type-specific neuronal plasticity mechanisms underlying these changes within the POA, however, are unknown. Using ex-vivo slice electrophysiology and in vivo imaging, I propose to characterize acclimation- and obesity-induced plasticity of thermoregulatory neurons. Ultimately, I aim to manipulate thermoregulatory neuron plasticity to test its potential counter-balancing effect on obesity.

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The information about "ACCLIMATIZE" are provided by the European Opendata Portal: CORDIS opendata.

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