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4D-GenEx SIGNED

Spatio-temporal Organization and Expression of the Genome

Total Cost €

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EC-Contrib. €

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Partnership

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 4D-GenEx project word cloud

Explore the words cloud of the 4D-GenEx project. It provides you a very rough idea of what is the project "4D-GenEx" about.

underlying    critically    hi    functional    cellular    pathological    probing    dynamics    subnuclear    organization    physical    certain    dimensions    science    microenvironment    responding    expression    pp7    molecule    signal    physics    time    innovative    positions    experiment    impairing    communicate    modeling    relationship    regulation    combines    interface    theory    labeling    understand    coordinate    computer    shared    ms2    relation    motion    acting    cluster    chromosomes    shape    visualize    extract    imaging    local    space    preferred    color    investigates    biology    dual    interpreting    regulated    nucleus    first    locus    conformational    compartments    coupling    mechanisms    responsive    normal    competition    indicates    live    tracking    stochastic    supercoiling    suggest    statistical    genes    co    perturbations    hormone    single    individual    expertise    spatio    edge    gene    hypothesis    noise    rna    building    cutting    validate    uncover    tools    enhancers    transcription    linear    4d    organizing    transcriptional    recycling    analytical    fish    domain    appropriate    lack    patterns    relates    data    temporal    experimental    coordinated    genome    signatures    pairs   

Project "4D-GenEx" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙499˙750 €
 EC max contribution 1˙499˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2023-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙499˙750.00

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 Project objective

This project investigates the two-way relationship between spatio-temporal genome organization and coordinated gene regulation, through an approach at the interface between physics, computer science and biology.

In the nucleus, preferred positions are observed from chromosomes to single genes, in relation to normal and pathological cellular states. Evidence indicates a complex spatio-temporal coupling between co-regulated genes: e.g. certain genes cluster spatially when responding to similar factors and transcriptional noise patterns suggest domain-wide mechanisms. Yet, no individual experiment allows probing transcriptional coordination in 4 dimensions (FISH, live locus tracking, Hi-C...). Interpreting such data also critically requires theory (stochastic processes, statistical physics…). A lack of appropriate experimental/analytical approaches is impairing our understanding of the 4D genome.

Our proposal combines cutting-edge single-molecule imaging, signal-theory data analysis and physical modeling to study how genes coordinate in space and time in a single nucleus. Our objectives are to understand (a) competition/recycling of shared resources between genes within subnuclear compartments, (b) how enhancers communicate with genes domain-wide, and (c) the role of local conformational dynamics and supercoiling in gene co-regulation. Our organizing hypothesis is that, by acting on their microenvironment, genes shape their co-expression with other genes.

Building upon my expertise, we will use dual-color MS2/PP7 RNA labeling to visualize for the first time transcription and motion of pairs of hormone-responsive genes in real time. With our innovative signal analysis tools, we will extract spatio-temporal signatures of underlying processes, which we will investigate with stochastic modeling and validate through experimental perturbations. We expect to uncover how the functional organization of the linear genome relates to its physical properties and dynamics in 4D.

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The information about "4D-GENEX" are provided by the European Opendata Portal: CORDIS opendata.

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