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4D-GenEx SIGNED

Spatio-temporal Organization and Expression of the Genome

Total Cost €

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EC-Contrib. €

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Partnership

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 4D-GenEx project word cloud

Explore the words cloud of the 4D-GenEx project. It provides you a very rough idea of what is the project "4D-GenEx" about.

edge    hi    critically    signatures    cutting    ms2    4d    pairs    positions    supercoiling    linear    statistical    communicate    relation    signal    perturbations    individual    extract    innovative    relates    tracking    interface    first    gene    time    coupling    genes    color    physics    single    experiment    conformational    local    functional    transcription    regulation    preferred    shared    biology    understand    enhancers    certain    dimensions    imaging    patterns    organizing    dual    hormone    computer    acting    genome    spatio    shape    nucleus    impairing    rna    space    investigates    mechanisms    stochastic    fish    underlying    responding    theory    expression    temporal    suggest    data    hypothesis    science    chromosomes    molecule    building    domain    tools    combines    locus    experimental    uncover    coordinate    expertise    compartments    live    modeling    probing    validate    cellular    normal    interpreting    lack    regulated    co    relationship    recycling    visualize    noise    pp7    appropriate    analytical    responsive    organization    subnuclear    transcriptional    microenvironment    coordinated    competition    indicates    labeling    cluster    pathological    physical    dynamics    motion   

Project "4D-GenEx" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙499˙750 €
 EC max contribution 1˙499˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2023-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙499˙750.00

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 Project objective

This project investigates the two-way relationship between spatio-temporal genome organization and coordinated gene regulation, through an approach at the interface between physics, computer science and biology.

In the nucleus, preferred positions are observed from chromosomes to single genes, in relation to normal and pathological cellular states. Evidence indicates a complex spatio-temporal coupling between co-regulated genes: e.g. certain genes cluster spatially when responding to similar factors and transcriptional noise patterns suggest domain-wide mechanisms. Yet, no individual experiment allows probing transcriptional coordination in 4 dimensions (FISH, live locus tracking, Hi-C...). Interpreting such data also critically requires theory (stochastic processes, statistical physics…). A lack of appropriate experimental/analytical approaches is impairing our understanding of the 4D genome.

Our proposal combines cutting-edge single-molecule imaging, signal-theory data analysis and physical modeling to study how genes coordinate in space and time in a single nucleus. Our objectives are to understand (a) competition/recycling of shared resources between genes within subnuclear compartments, (b) how enhancers communicate with genes domain-wide, and (c) the role of local conformational dynamics and supercoiling in gene co-regulation. Our organizing hypothesis is that, by acting on their microenvironment, genes shape their co-expression with other genes.

Building upon my expertise, we will use dual-color MS2/PP7 RNA labeling to visualize for the first time transcription and motion of pairs of hormone-responsive genes in real time. With our innovative signal analysis tools, we will extract spatio-temporal signatures of underlying processes, which we will investigate with stochastic modeling and validate through experimental perturbations. We expect to uncover how the functional organization of the linear genome relates to its physical properties and dynamics in 4D.

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The information about "4D-GENEX" are provided by the European Opendata Portal: CORDIS opendata.

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