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HEIREC

HEI10-mediated elevations in bread wheat recombination

Total Cost €

EC-Contrib. €

Partnership

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HEIREC project word cloud

Explore the words cloud of the HEIREC project. It provides you a very rough idea of what is the project "HEIREC" about.

arms deteriorating strain animals copies security track synthhotspot cycles proof varieties grant globally crossovers accelerate conserved predicted chromosome traits arabidopsis society environments limits gene improvement regulator time doubled plant takes molecular variety ubiquitin demand urgent changing plants species hybridized crossover hei10 decades introduction thereby recombination demands wheat reduce strains context breeding dosage bread generate erc data companies food meiotic e3 copy diverse crop ligase fast coming discovered sensitive additional fungi platform encodes climate manipulate away consolidator tool light heirec model yielding combine frequency

Project "HEIREC" data sheet

The following table provides information about the project.

Coordinator	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	150˙000 €
EC max contribution	150˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-PoC
Funding Scheme	ERC-POC
Starting year	2018
Duration (year-month-day)	from 2018-04-01 to 2019-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	coordinator	150˙000.00

Map

Project objective

The increasing demand for food, in the context of a changing climate and deteriorating environments, will be one of the major challenges facing society in the coming decades. However, as breeding a new crop variety currently takes on average 10 years, the predicted changes in food demand and climate are only several breeding cycles away. Meiotic recombination and crossover is a major tool used in crop breeding when diverse strains are hybridized in order to combine useful traits. Therefore, in the current climate of change, there is an urgent need to reduce the time needed to produce new crop varieties, and meiotic recombination is one target to achieve this. In my ERC Consolidator grant SynthHotSpot, we are investigating the molecular control of meiotic recombination using the model plant Arabidopsis. We have identified the gene HEI10, which encodes a conserved meiotic ubiquitin E3 ligase, as a major regulator of crossover numbers. Importantly, during this work we discovered that HEI10 is highly dosage-sensitive and introduction of additional copies of this gene more than doubled crossovers throughout the Arabidopsis chromosome arms. As HEI10 is conserved between plants, fungi and animals, this may provide a gene target to manipulate crossover numbers in diverse species. In light of the demands on breeding companies to develop new, high yielding crop varieties, HEIREC will fast-track the development of a new platform technology to increase recombination frequency during breeding, via introduction of additional HEI10 copies. Within HEIREC we will generate proof of concept data where we increase HEI10 copy number within bread wheat, in order to increase recombination and thereby accelerate crop improvement. Bread wheat is a major crop globally where recombination level limits strain improvement. Therefore, by increasing recombination frequency during breeding, HEIREC will accelerate the development of new crop varieties and contribute to ensuring food security.

Publications

List of publications.
year	authors and title	journal	last update
2019	Emma J. Lawrence, Hongbo Gao, Andrew J. Tock, Christophe Lambing, Alexander R. Blackwell, Xiaoqi Feng, Ian R. Henderson Natural Variation in TBP-ASSOCIATED FACTOR 4b Controls Meiotic Crossover and Germline Transcription in Arabidopsis published pages: 2676-2686.e3, ISSN: 0960-9822, DOI: 10.1016/j.cub.2019.06.084	Current Biology 29/16	2020-01-29
2018	HeÃ¯di Serra, Christophe Lambing, Catherine H. Griffin, Stephanie D. Topp, Divyashree C. Nageswaran, Charles J. Underwood, Piotr A. Ziolkowski, Mathilde SÃ©guÃ©la-Arnaud, Joiselle B. Fernandes, RaphaÃ«l Mercier, Ian R. Henderson Massive crossover elevation via combination of HEI10 and recq4a recq4b during Arabidopsis meiosis published pages: 2437-2442, ISSN: 0027-8424, DOI: 10.1073/pnas.1713071115	Proceedings of the National Academy of Sciences 115/10	2020-01-29
2019	Joiselle B Fernandes, Piotr Wlodzimierz, Ian R Henderson Meiotic recombination within plant centromeres published pages: 26-35, ISSN: 1369-5266, DOI: 10.1016/j.pbi.2019.02.008	Current Opinion in Plant Biology 48	2020-01-29

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