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TRIANGLE SIGNED

A novel integrative strategy to prevent colorectal cancer within the diet-host-microbiota triangle: from organoids to human in vivo reality

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 TRIANGLE project word cloud

Explore the words cloud of the TRIANGLE project. It provides you a very rough idea of what is the project "TRIANGLE" about.

colon    80    microbiome    2d    nutrition    feces    recommendations    hints    digested    firstly    obese    mysteries    outcome    multiple    significantly    afterwards    secondly    life    published    phytochemicals    colorectal    efsa    claims    revealed    metabolically    death    assigned    healthy    compounds    batch    controversy    unveil    cancer    deepen    immortalized    cell    chemopreventive    vital    organoids    metabolomics    accounted    apple    donors    host    cells    vivo    vitro    tested    human    artificially    relationship    model    rejected    crc    anticancer    colonic    suspected    action    differ    integrative    proliferative    biological    dietary    lean    health    scenario    anti    polyphenol    context    report    prevention    benefits    diet    assays    mechanisms    metabolites    inoculated    lines    deduced    received    tools    decipher    strategy    despite    personalized    extrapolated    culture    nutritional    fermented    tumoroids    polyphenols    constituents   

Project "TRIANGLE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI TRENTO 

Organization address
address: VIA CALEPINA 14
city: TRENTO
postcode: 38122
website: www.unitn.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 168˙277 €
 EC max contribution 168˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2020-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI TRENTO IT (TRENTO) coordinator 168˙277.00

Map

 Project objective

Colorectal cancer (CRC) is the second cause of death in the EU, and so far, diet has been accounted for up to 80% of the cases. In this context, dietary phytochemicals have received increasing interest due to their suspected role in the prevention of cancer. Numerous studies report the chemopreventive effects of polyphenols. However, health benefits assigned to dietary constituents are still under controversy as can be deduced from the large number of applications rejected by the EFSA (health claims). Despite the crucial role of polyphenols in many biological cases, adequate tools to decipher the relationship between diet-microbiome-host are not yet available. To unveil the mysteries in the emerging field of personalized nutrition, this proposal aims to develop a new in vitro model for the study of phytochemicals in CRC prevention. The most common approach to study the anti-proliferative activity of polyphenols against CRC involves the use of 2D cell lines. Although multiple hints on the possible anticancer effects of these compounds have been already published, these results cannot be extrapolated to human. Firstly, immortalized 2D cell lines differ metabolically from in vivo cells. Secondly, these compounds were not artificially digested and fermented. Therefore, a novel integrative strategy to deepen understanding of CRC is vital. To accomplish this, a real-life scenario is needed. In this context, colon organoids/tumoroids will be established. Afterwards, an apple will be digested/fermented in vitro using a batch culture colonic model inoculated with feces from lean/obese healthy donors. In the end, such polyphenol metabolites will be tested in colon organoids/tumoroids and the mechanisms of action will be revealed by metabolomics and organoids assays. The outcome of this proposal will significantly deepen our knowledge of polyphenols-microbiome-organoids, and, in the long term, will allow nutritional recommendations to be given for the prevention of cancer.

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The information about "TRIANGLE" are provided by the European Opendata Portal: CORDIS opendata.

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