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PathEVome SIGNED

Do Pathogen Extracellular Vesicles Deliver Crop Disease?

Total Cost €

0

EC-Contrib. €

0

Partnership

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 PathEVome project word cloud

Explore the words cloud of the PathEVome project. It provides you a very rough idea of what is the project "PathEVome" about.

route    vesicles    biogenesis    accumulate    biology    significantly    devastating    packaged    food    routes    throughput    innovative    electron    laboratory    discovery    living    wp3    extracellular    microscopy    breaking    vesicular    secretory    components    global    workpackage    critical    debated    pathogen    answered    inside    endocytic    wp1    oomycetes    editing    automated    cytoplasmic    molecular    establishes    effectors    reside    delivered    corresponding    host    fungi    secreted    proteins    formed    question    filamentous    pathogens    disease    endocytosis    translocated    fusion    suppress    crop    ground    determined    cells    plant    genome    pathevome    security    proteome    effector    broadly    biological    cell    implicating    final    proteomics    infection    destination    scientific    tools    interface    dimensional    arsenal    brings    immunity    vital    causing    organisation    diseases    ev    breakthrough    transgenic    hotly    resolve    traffic    wp2    wp    revealed    pathology    virulence    transport    threaten    roles    them    evs   

Project "PathEVome" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF DUNDEE 

Organization address
address: Nethergate
city: DUNDEE
postcode: DD1 4HN
website: www.dundee.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙468˙260 €
 EC max contribution 2˙468˙260 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2023-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF DUNDEE UK (DUNDEE) coordinator 2˙130˙541.00
2    THE JAMES HUTTON INSTITUTE UK (DUNDEE) participant 337˙719.00

Map

 Project objective

Filamentous plant pathogens (fungi and oomycetes) cause the most devastating crop diseases and thus significantly threaten global food security. Essential components of their virulence arsenal are proteins called cytoplasmic effectors that are delivered inside plant cells to suppress immunity. One of the major scientific challenges in this field is understanding how effectors are secreted and translocated into host cells; a question that is hotly debated. An exciting breakthrough in my laboratory revealed that cytoplasmic effectors accumulate in extracellular vesicles (EVs), implicating this as a delivery route. This critical discovery establishes a vital need to address: • What proteins reside in EVs and how do EVs traffic them between pathogen and host cells? • How are EVs formed and how are effectors packaged into them? • What are the routes for uptake of cytoplasmic effectors into host cells and how do they reach their destination?

Each question will be answered by a corresponding workpackage (WP) that brings challenging, innovative approaches to the study of molecular plant pathology. In WP1 proteomics and transgenic approaches will allow the EV proteome to be determined and high-throughput automated electron microscopy will resolve the 3-dimensional organisation of the interface between plant and pathogen. In WP2, new molecular cell biological approaches and genome editing will facilitate an understanding of effector secretory routes and EV biogenesis. In WP3, fusion or endocytosis of EVs with plant cells will be studied and the endocytic routes to delivery of effectors to their final destination will be defined. PathEVome will develop a ground-breaking understanding of effector delivery from filamentous pathogens to the inside of living plant cells. It will provide tools and approaches beyond the current state-of-the-art in infection cell biology that can be broadly adopted to study the roles of vesicular transport in causing disease.

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The information about "PATHEVOME" are provided by the European Opendata Portal: CORDIS opendata.

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