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HAZARDOmics SIGNED

Liquid Chromatography-Ion Mobility-Mass Spectrometry and Capillary Electrophoresis-Mass Spectrometry as ground-breaking approaches to expand the boundaries of metabolomics in chemical risk assessment

Total Cost €

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EC-Contrib. €

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Partnership

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 HAZARDOmics project word cloud

Explore the words cloud of the HAZARDOmics project. It provides you a very rough idea of what is the project "HAZARDOmics" about.

mobility    boundaries    action    rp    technique    arising    biomarkers    society    strategy    chromatography    reverse    workflow    public    resolution    enforcement    moa    perspective    lc    mass    innovative    metabolomics    emerged    connection    complete    compounds    purposes    human    priorities    sense    exposures    community    consequently    understand    analytical    first    interaction    health    profiling    pcbs    hydrophilic    bisphenol    risk    ion    fingerprint    hrms    exposure    additional    discovery    blood    spectrometry    hilic    liquid    samples    framework    techniques    civil    breaking    doses    broad    mechanisms    extended    involve    ce    chemicals    modes    polychlorinated    effect    im    obtain    time    serum    strategies    intended    possibility    metabolic    ground    bpa    chemical    diseases    edcs    hazardomics    complementary    disruptor    bisphenyls    cocktail    prevention    endocrine    electrophoresis    employed    nowadays    risks    chronic    separation    capillary   

Project "HAZARDOmics" data sheet

The following table provides information about the project.

Coordinator
ECOLE NATIONALE VETERINAIRE, AGROALIMENTAIRE ET DE L'ALIMENTATION NANTES ATLANTIQUE 

Organization address
address: Site de la Chantrerie, Route de Gachet
city: NANTES
postcode: 44307
website: www.oniris-nantes.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE NATIONALE VETERINAIRE, AGROALIMENTAIRE ET DE L'ALIMENTATION NANTES ATLANTIQUE FR (NANTES) coordinator 185˙076.00

Map

 Project objective

Nowadays, there is a growing concern in the research community and civil society in general about the effects of chemical exposure on human health. From a public health perspective, it is of major interest to establish the risks associated with chemicals for the enforcement of health prevention strategies. In this sense, one of the current priorities of chemical risk assessment is to understand the effects and modes of action (MoA) of endocrine disruptor compounds (EDCs) such as bisphenol A (BPA) and polychlorinated bisphenyls (PCBs). Within this framework, metabolomics has emerged as a novel strategy for the discovery of effect biomarkers that can provide the connection between exposures to EDCs and chronic diseases. HAZARDOmics aims to enhance the knowledge about the risks arising from exposures to low doses of BPA and to a ‘cocktail’ of PCBs following an innovative metabolomics approach. The metabolic profiling of blood serum samples will be investigated from a broad analytical perspective in order to obtain the most complete information of metabolic fingerprint and, consequently, to increase the possibility of identifying effect biomarkers. Liquid chromatography (LC)-High Resolution Mass Spectrometry (HRMS) involving Reverse Phase Liquid Chromatography (RP-LC) and Hydrophilic Interaction Liquid Chromatography (HILIC) will be employed as traditional metabolomics strategy in risk assessment. On the other hand, the boundaries of this approach will be extended by the application of two additional techniques. For the first time, Ion Mobility Spectrometry (IM) integrated in a LC-HRMS workflow will be evaluated as a ground-breaking technology for metabolomics intended to risk assessment purposes. Moreover, Capillary Electrophoresis (CE)-HRMS will be implemented as complementary technique to LC-HRMS since both involve different separation mechanisms.

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