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HAZARDOmics SIGNED

Liquid Chromatography-Ion Mobility-Mass Spectrometry and Capillary Electrophoresis-Mass Spectrometry as ground-breaking approaches to expand the boundaries of metabolomics in chemical risk assessment

Total Cost €

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EC-Contrib. €

0

Partnership

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 HAZARDOmics project word cloud

Explore the words cloud of the HAZARDOmics project. It provides you a very rough idea of what is the project "HAZARDOmics" about.

health    prevention    risk    innovative    rp    priorities    hazardomics    effect    reverse    exposures    compounds    ion    mobility    enforcement    resolution    techniques    capillary    nowadays    polychlorinated    diseases    mechanisms    technique    ground    endocrine    metabolomics    intended    broad    workflow    breaking    lc    bpa    edcs    disruptor    understand    public    strategy    chemical    additional    community    hilic    complete    perspective    chromatography    time    chronic    separation    samples    discovery    complementary    liquid    cocktail    bisphenyls    electrophoresis    connection    profiling    boundaries    purposes    analytical    fingerprint    exposure    sense    risks    civil    human    im    action    ce    spectrometry    blood    involve    arising    modes    extended    pcbs    first    strategies    employed    metabolic    chemicals    consequently    doses    interaction    serum    obtain    moa    mass    bisphenol    possibility    biomarkers    hydrophilic    framework    emerged    society    hrms   

Project "HAZARDOmics" data sheet

The following table provides information about the project.

Coordinator
ECOLE NATIONALE VETERINAIRE, AGROALIMENTAIRE ET DE L'ALIMENTATION NANTES ATLANTIQUE 

Organization address
address: Site de la Chantrerie, Route de Gachet
city: NANTES
postcode: 44307
website: www.oniris-nantes.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE NATIONALE VETERINAIRE, AGROALIMENTAIRE ET DE L'ALIMENTATION NANTES ATLANTIQUE FR (NANTES) coordinator 185˙076.00

Map

 Project objective

Nowadays, there is a growing concern in the research community and civil society in general about the effects of chemical exposure on human health. From a public health perspective, it is of major interest to establish the risks associated with chemicals for the enforcement of health prevention strategies. In this sense, one of the current priorities of chemical risk assessment is to understand the effects and modes of action (MoA) of endocrine disruptor compounds (EDCs) such as bisphenol A (BPA) and polychlorinated bisphenyls (PCBs). Within this framework, metabolomics has emerged as a novel strategy for the discovery of effect biomarkers that can provide the connection between exposures to EDCs and chronic diseases. HAZARDOmics aims to enhance the knowledge about the risks arising from exposures to low doses of BPA and to a ‘cocktail’ of PCBs following an innovative metabolomics approach. The metabolic profiling of blood serum samples will be investigated from a broad analytical perspective in order to obtain the most complete information of metabolic fingerprint and, consequently, to increase the possibility of identifying effect biomarkers. Liquid chromatography (LC)-High Resolution Mass Spectrometry (HRMS) involving Reverse Phase Liquid Chromatography (RP-LC) and Hydrophilic Interaction Liquid Chromatography (HILIC) will be employed as traditional metabolomics strategy in risk assessment. On the other hand, the boundaries of this approach will be extended by the application of two additional techniques. For the first time, Ion Mobility Spectrometry (IM) integrated in a LC-HRMS workflow will be evaluated as a ground-breaking technology for metabolomics intended to risk assessment purposes. Moreover, Capillary Electrophoresis (CE)-HRMS will be implemented as complementary technique to LC-HRMS since both involve different separation mechanisms.

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