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SYNPATH SIGNED

Regulation of synaptic development and plasticity by molecular pathways linked to human evolution

Total Cost €

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EC-Contrib. €

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Partnership

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 SYNPATH project word cloud

Explore the words cloud of the SYNPATH project. It provides you a very rough idea of what is the project "SYNPATH" about.

cells    indicates    maturation    dendrites    rules    linked    resolution    robo    microscopy    stores    synapse    densely    differ    bridge    srgap2    neurobiology    relies    few    manipulations    plasticity    integrates    composition    function    mass    intact    governing    molecular    synaptic    duplicated    synapses    single    transfers    implicated    live    cell    evolution    molecule    disorders    spectrometry    transmission    mouse    fundamental    traits    duplications    neurons    shape    gtpase    vivo    combination    genes    employ    electrophysiology    engineering    cellular    body    protein    super    primate    machine    supporting    circuits    multimolecular    distributed    rodent    mechanisms    nanoscale    rho    takes    thread    stem    framework    cortical    models    understand    uncover    networks    gap    cognitive    dysfunctions    dynamics    brain    mammalian    underlying    interactions    pluripotent    activating    advantage    disciplinary    human    protracted    goals    regulation    humans    specialized    neurodevelopmental    species    regulations    period    slit   

Project "SYNPATH" data sheet

The following table provides information about the project.

Coordinator		 INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country France [FR]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2024-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 1˙500˙000.00

Map

 Project objective

The synapse is a nanoscale machine, which transfers, integrates and stores information in brain circuits. Its function relies on multimolecular networks of interactions whose composition and dynamics shape synaptic transmission. A large body of evidence indicates that synapses specialized in humans. Human synapses are more densely distributed along dendrites and their period of maturation is protracted compared to rodent or non-human primate synapses. The rules governing their plasticity also differ from the other mammalian species studied so far. These traits contribute to the formation and function of complex circuits supporting human cognitive abilities. Yet, the underlying molecular mechanisms are not known. Here we will investigate the role of molecular pathways linked to human evolution in the regulation of synaptic development and plasticity. The proposed research takes advantage of my previous work on Slit-Robo Rho GTPAse-activating protein 2 (SRGAP2), one of the few genes specifically duplicated in humans, and the only one implicated at synapses so far. We will use the duplications of SRGAP2 as a thread to uncover i) fundamental mechanisms of synaptic development and plasticity, and ii) regulations specific to human synapses. To achieve our goals, we will employ a multi-disciplinary approach based on in vivo manipulations in intact mouse cortical circuits, mass spectrometry, live-cell single-molecule super-resolution microscopy, electrophysiology, and engineering of cortical neurons derived from human pluripotent stem cells. The combination of mouse and human models will allow us to establish a robust framework to bridge the gap in knowledge between cellular neurobiology and human brain evolution, and better understand synaptic dysfunctions in neurodevelopmental disorders.

 Deliverables

List of deliverables.
Data Management Plan Open Research Data Pilot 2020-02-12 18:04:20

Take a look to the deliverables list in detail:  detailed list of SYNPATH deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Matteo Fossati, Nora Assendorp, Olivier Gemin, Sabrina Colasse, Florent Dingli, Guillaume Arras, Damarys Loew, Cécile Charrier
Trans-Synaptic Signaling through the Glutamate Receptor Delta-1 Mediates Inhibitory Synapse Formation in Cortical Pyramidal Neurons
published pages: , ISSN: 0896-6273, DOI: 10.1016/j.neuron.2019.09.027 		Neuron 2019-11-22

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