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MICROB-PREDICT SIGNED

MICROBiome-based biomarkers to PREDICT decompensation of liver cirrhosis and treatment response

Total Cost €

EC-Contrib. €

Partnership

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MICROB-PREDICT project word cloud

Explore the words cloud of the MICROB-PREDICT project. It provides you a very rough idea of what is the project "MICROB-PREDICT" about.

carries omics risk possibly clinical personalized personalize smartphone assemble stratify sites acute manner causally visits deaths tools experts patient metabolizes point channel signatures enrich chronic edge liver decompensated validate association world tests scientific gut interaction progression respect holistic 12 alter individual first causes health cirrhosis accurate randomized functionalities patients connected communication technologies powerful determines nanobiosensors body predict care million drugs trial cutting specialists shapes hepatology samples understand treatment gt aclf excellence easl longitudinal host elpa microbiome prediction international axis interactome microb sequential confounders leaders stratification biomarkers decompensation collected data person

Project "MICROB-PREDICT" data sheet

The following table provides information about the project.

Coordinator	EUROPEAN FOUNDATION FOR THE STUDY OF CHRONIC LIVER FAILURE (EF-CLIF) Organization address address: TRAVESSERA DE GRACIA 11, 7TH FLOOR city: BARCELONA postcode: 8021 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	15˙000˙002 €
EC max contribution	15˙000˙000 € (100%)
Programme	1. H2020-EU.3.1.2. (Preventing disease)
Code Call	H2020-SC1-2018-Single-Stage-RTD
Funding Scheme	RIA
Starting year	2019
Duration (year-month-day)	from 2019-01-01 to 2025-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	EUROPEAN FOUNDATION FOR THE STUDY OF CHRONIC LIVER FAILURE (EF-CLIF) EUROPEAN FOUNDATION FOR THE STUDY OF CHRONIC LIVER FAILURE (EF-CLIF) Organization address address: TRAVESSERA DE GRACIA 11, 7TH FLOOR city: BARCELONA postcode: 8021 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	coordinator	2˙273˙400.00
2	EUROPEAN MOLECULAR BIOLOGY LABORATORY EUROPEAN MOLECULAR BIOLOGY LABORATORY Organization address address: Meyerhofstrasse 1 city: HEIDELBERG postcode: 69117 website: http://www.embl.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	participant	2˙021˙900.00
3	KOBENHAVNS UNIVERSITET KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN)	participant	1˙246˙100.00
4	FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA Organization address address: CAMPUS DE LA UAB EDIFICI Q ICN2 city: BELLATERRA (BARCELONA) postcode: 8193 website: www.icn.cat contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BELLATERRA (BARCELONA))	participant	1˙089˙400.00
5	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: MUENCHEN postcode: 80539 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	996˙000.00
6	ODENSE UNIVERSITETSHOSPITAL ODENSE UNIVERSITETSHOSPITAL Organization address address: Sdr. Boulevard 29 city: ODENSE postcode: 5000 website: www.ouh.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (ODENSE)	participant	800˙000.00
7	COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES Organization address address: RUE LEBLANC 25 city: PARIS 15 postcode: 75015 website: www.cea.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS 15)	participant	648˙000.00
8	JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN Organization address address: THEODOR W ADORNO PLATZ 1 city: FRANKFURT AM MAIN postcode: 60323 website: www.uni-frankfurt.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (FRANKFURT AM MAIN)	participant	635˙000.00
9	INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT Organization address address: Rue De L'Universite 147 city: PARIS CEDEX 07 postcode: 75338 website: www.inra.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS CEDEX 07)	participant	620˙000.00
10	KATHOLIEKE UNIVERSITEIT LEUVEN KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: OUDE MARKT 13 city: LEUVEN postcode: 3000 website: www.kuleuven.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LEUVEN)	participant	620˙000.00
11	Concentris Research Management GmbH Concentris Research Management GmbH Organization address address: Ludwigstr. 4 city: Fürstenfeldbruck postcode: D-82256 website: www.concentris.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Fürstenfeldbruck)	participant	535˙000.00
12	ACADEMISCH ZIEKENHUIS LEIDEN ACADEMISCH ZIEKENHUIS LEIDEN Organization address address: ALBINUSDREEF 2 city: LEIDEN postcode: 2333 ZA website: www.lumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	500˙500.00
13	KING'S COLLEGE LONDON KING'S COLLEGE LONDON Organization address address: STRAND city: LONDON postcode: WC2R 2LS website: www.kcl.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	500˙000.00
14	VAIOMER VAIOMER Organization address address: 516 RUE PIERRE ET MARIE CURIE PROLOGUE BIOTECH city: LABEGE postcode: 31670 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (LABEGE)	participant	484˙000.00
15	FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA Organization address address: CARRER ROSSELLO 149 city: BARCELONA postcode: 8036 website: www.fundacioclinic.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	460˙000.00
16	UNIVERSITY COLLEGE LONDON UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	423˙500.00
17	DEBRECENI EGYETEM DEBRECENI EGYETEM Organization address address: EGYETEM TER 1 city: DEBRECEN postcode: 4032 website: http://www.unideb.hu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	HU (DEBRECEN)	participant	347˙000.00
18	BIOBYTE SOLUTIONS GMBH BIOBYTE SOLUTIONS GMBH Organization address address: Bothestrasse 142 city: Heidelberg postcode: 69126 website: www.biobyte.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Heidelberg)	participant	290˙000.00
19	UNIVERSITAT DE BARCELONA UNIVERSITAT DE BARCELONA Organization address address: GRAN VIA DE LES CORTS CATALANES 585 city: BARCELONA postcode: 8007 website: http://www.ub.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	224˙000.00
20	UNIVERSITETET I OSLO UNIVERSITETET I OSLO Organization address address: PROBLEMVEIEN 5-7 city: OSLO postcode: 313 website: www.uio.no contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (OSLO)	participant	150˙000.00
21	EUROPEAN LIVER PATIENTS ASSOCIATION EUROPEAN LIVER PATIENTS ASSOCIATION Organization address address: RUE DE LA LOI 235/27 city: BRUXELLES postcode: 1040 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BRUXELLES)	participant	80˙000.00
22	EUROPEAN ASSOCIATION FOR THE STUDYOF THE LIVER EUROPEAN ASSOCIATION FOR THE STUDYOF THE LIVER Organization address address: LOWENSTRASSE 1 city: ZURICH postcode: 8001 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ZURICH)	participant	56˙200.00

Map

Project objective

Decompensation of liver cirrhosis and progression towards acute-on-chronic liver failure (ACLF) causes 1.2 million deaths/year. Microbiome is causally involved in cirrhosis progression and is for drugs the first interaction point with the patients. Drugs can alter the microbiome leading to unwanted effects or even facilitating their effects, but the microbiome metabolizes the drugs, shapes their effects and possibly determines the host response to drugs. As each person carries an individual microbiome, insight in these processes should help stratify or even personalize patient health care and treatment. The aims of MICROB-PREDICT are 1) to better understand the role of microbiome and the gut-liver-axis interactome with respect to microbiome functionalities, 2) to identify and validate microbiome-based biomarkers and signatures for personalized prediction of decompensation and ACLF, and response to treatment, 3) to design three new tests as easy-to-use tools and point-of-care, smartphone-connected nanobiosensors, and 4) to validate them in a randomized controlled trial. MICROB-PREDICT will assemble existing data and samples from major microbiome initiatives in hepatology (12 international studies, >10,000 patients), and enrich them with holistic and in-depth analysis using cutting-edge multi-omics technologies of host and microbiome from different body sites in samples of >1,000 patients collected in a longitudinal manner with sequential visits and controlling for confounders. MICROB-PREDICT results will foster more accurate, personalized risk stratification and significant steps towards personalized treatment of decompensated cirrhosis and ACLF. World-leading microbiome specialists, technology leaders and clinical experts make this a programme of scientific excellence; patient organisations (ELPA) and the European Association for the study of the Liver (EASL) will channel our results into a powerful dissemination, communication and exploitation programme.

Deliverables

List of deliverables.
Project brochure and professional templates	Websites, patent fillings, videos etc.	2020-04-25 11:37:03
Go-online of the public project website	Websites, patent fillings, videos etc.	2020-04-25 11:37:03

Take a look to the deliverables list in detail: detailed list of MICROB-PREDICT deliverables.

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