Opendata, web and dolomites
  1. home
  2. trasparenza
  3. open h2020
  4. decryption

deCrYPtion SIGNED

Decrypting Mycobacterium cytochrome P450 (CYP) physiological functions by testing hypotheses emitted form large-scale comparative genomics analysis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 deCrYPtion project word cloud

Explore the words cloud of the deCrYPtion project. It provides you a very rough idea of what is the project "deCrYPtion" about.

performed    biodiversity    organisms    million    cytochrome    tuberculosis    attributed    antimycobacterial    2016    extremely    eradication    physiological    more    illustrates    family    complementary    genetics    suppresses    united    enzymes    genus    swansea    tb    combination    drug    proteins    preliminary    human    undertaken    frequently    considerations    determinant    shown    worldwide    cyp    perform    action    infectious    prove    validate    representative    resistances    biochemical    190    antibiotics    kelly    orthologous    hypotheses    powerful    inhibition    animals    appeared    stringent    infection    species    drugs    wales    prof    causative    belong    fundamental    centre    incentives    p450    genomics    economic    lives    groups    livestock    steven    orphan    cyps    decryption    pathogenic    antibiotic    belonging    functions    responsible    supervision    context    encoded    lost    agents    protein    mycobacterium    experiments    conserved    kingdom    mycobacterial    function    university    unfortunately    deaths   

Project "deCrYPtion" data sheet

The following table provides information about the project.

Coordinator		 SWANSEA UNIVERSITY 

Organization address
address: SINGLETON PARK
city: SWANSEA
postcode: SA2 8PP
website: www.swan.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SWANSEA UNIVERSITY UK (SWANSEA) coordinator 212˙933.00

Map

 Project objective

More than 190 species belong to the Mycobacterium genus. Among those, several are pathogenic to human and animals. The high number of human lives lost and the economic consequences of livestock infection are important incentives in the control and eradication of the responsible organisms. M. tuberculosis, one of the causative agents of tuberculosis (TB), is the most problematic representative: in 2016, 1.7 million deaths worldwide have been attributed to TB. Like for other infectious organisms, antibiotic resistances have appeared in Mycobacterium. Thus, there is a fundamental need to develop new antimycobacterial drugs. The inhibition of enzymes belonging to the Cytochrome P450 (CYP) protein family has been shown to suppresses the growth of several Mycobacterium species, making CYPs targets for drug development. Unfortunately, most CYPs are considered orphan: proteins for which no physiological function is known. The deCrYPtion action aims to define the physiological function of a selected set of mycobacterial CYPs. It will prove determinant in the development of new antibiotics. I will perform a large-scale comparative genomics analysis of the CYPs encoded by Mycobacterium species, in order to define orthologous groups and identify, for each, conserved partners and pathway context. This approach is extremely powerful (even if not frequently used) and allow to propose physiological functions, based on the information obtained. Specific CYPs to be characterized will be selected based on a set of stringent considerations, including their potential as drug targets. A preliminary analysis illustrates the approach that will be used. A combination of complementary biochemical, genetics and physiological experiments will be performed to validate the hypotheses generated. deCrYPtion will be undertaken within the Centre for Cytochrome P450 Biodiversity, under the supervision of Prof Steven Kelly, at Swansea University (Wales, United Kingdom).

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "DECRYPTION" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "DECRYPTION" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

GrowthDevStability (2020)

Characterization of the developmental mechanisms ensuring a robust symmetrical growth in the bilateral model organism Drosophila melanogaster

Read More  

EngPTC2 (2019)

Exploring new technologies for the next generation pulse tube cryocooler below 2K

Read More  

NarrowbandSSL (2019)

Development of Narrow Band Blue and Red Emitting Macromolecules for Solution-Processed Solid State Lighting Devices

Read More