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POLAR STAR SIGNED

Polymeric cyclodextrin-based nanoparticles for combination therapy of castrate-resistant prostate cancer

Total Cost €

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EC-Contrib. €

0

Partnership

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 POLAR STAR project word cloud

Explore the words cloud of the POLAR STAR project. It provides you a very rough idea of what is the project "POLAR STAR" about.

biocompatible    few    polymeric    frame    vivo    treat    animal    overcome    drug    resistant    fda    combination    battle    worldwide    teams    nanomedicine    chemistry    clinical    castrate    characterization    guided    cultures    latest    administer    profiles    therapy    mind    environment    public    oncogenic    survival    responsivity    multidisciplinary    form    nanotechnology    loaded    upgrade    strategy    researcher    reduce    cancer    full    pursued    exert    reciprocal    expertise    cargo    prostate    transfer    innovative    approved    fifth    holds    resistance    fellow    patient    suffering    premises    pc    biological    final    complementary    multiple    death    private    cyclodextrins    possibility    nanocarrier    secondments    multidrug    agents    cell    lot    advantage    plan    chemico    drugs    synergically    3d    benefit    treatment    skills    star    nanocarriers    contemporarily    keeping    hosting    complete    actors    experiments    tracking    tests    blocks    polar    selectivity    polymers    apporach    tissue    organic    supervisor    leaving    forefront    therapeutic    physical    models    mixed    building    academic    creates    chances    efficacy   

Project "POLAR STAR" data sheet

The following table provides information about the project.

Coordinator
CONSIGLIO NAZIONALE DELLE RICERCHE 

Organization address
address: PIAZZALE ALDO MORO 7
city: ROMA
postcode: 185
website: www.cnr.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 171˙473 €
 EC max contribution 171˙473 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2021-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) coordinator 171˙473.00

Map

 Project objective

Prostate cancer (PC) is the fifth leading cause of cancer-related death worldwide. PC often presents in its Multidrug resistant form leaving the patient few survival chances. New approaches are required to overcome resistance-related problems in PC and nanomedicine holds a lot of premises to effectively contribute in this battle. In this frame POLAR STAR aims at the implementation of combination therapy to treat castrate-resistant PC. Our strategy is to exploit innovative nanotechnology to administer contemporarily different therapeutic agents that synergically exert their activity across multiple oncogenic pathways. We plan to use new mixed polymers based on biocompatible cyclodextrins as these building blocks are already FDA approved. Simple organic chemistry is pursued to implement target selectivity and in vivo tracking of the polymeric nanocarrier. The design is guided by the final goal, the future clinical application of nanocarriers to improve PC treatment, keeping in mind upgrade of the nanocarrier systems to large scale production. We will focus on the latest PC drugs suffering from side effects and emerging resistance as multiple cargo to be loaded. Full chemico-physical characterization of the systems is planned as well as assessment of the efficacy of loaded nanocarriers in cell cultures with different drug responsivity profiles. In order to reduce animal experiments POLAR STAR will take full advantage of 3D prostate tissue models for biological tests, an apporach at the forefront in drug design. We plan to reach our goal bringing together the expertise of the fellow and the supervisor supported by the private and academic teams hosting the fellow during secondments. POLAR STAR creates a multidisciplinary environment where all actors, public and private, will benefit from reciprocal transfer of knowledge. During the project the fellow will have the possibility to become a complete researcher improving also complementary skills.

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The information about "POLAR STAR" are provided by the European Opendata Portal: CORDIS opendata.

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