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MitoWild SIGNED

Counting the cost of living: mitochondrial efficiency, environmental conditions, and performance in the wild

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

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 MitoWild project word cloud

Explore the words cloud of the MitoWild project. It provides you a very rough idea of what is the project "MitoWild" about.

minute    an    conceptual    measuring    consumption    trait    generally    estimating    efficiency    ecological    link    indirectly    influences    ros    insights    environmental    usual    re    distance    shifting    fold    equivalent    revealed    animal    textbook    capacity    car    perform    history    atp    onto    cutting    first    actually    experimental    natural    ecology    constrains    edge    balance    fish    energy    performance    oxygen    evaluation    examine    empirical    phenotypes    significantly    travelled    animals    reveal    off    dress    definitions    simultaneous    speed    fitness    life    techniques    trade    fuel    instead    conventional    living    mitochondria    contains    variation    predict    completely    senescence    metabolic    physiology    achieves    select    habitats    rates    rate    central    attempt    mitochondrial    hence    record    time    refer    weakness    hidden    expectation    totally    links    aerobic    laboratory    organism    actual    individuals    weaken    freshwater   

Project "MitoWild" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF GLASGOW 

Organization address
address: UNIVERSITY AVENUE
city: GLASGOW
postcode: G12 8QQ
website: www.gla.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙445˙128 €
 EC max contribution 2˙445˙128 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF GLASGOW UK (GLASGOW) coordinator 2˙445˙128.00

Map

 Project objective

An organism’s metabolic rate is a central trait that links its physiology with its ecology and life history. However, while textbook definitions of metabolic rate generally refer to the rate of energy use by the animal, most empirical studies instead record it very indirectly as whole-animal oxygen consumption rate, without any actual measurement of ATP production. This approach contains a conceptual weakness: it is equivalent to estimating a car’s capacity or efficiency by measuring its fuel consumption per minute, with no measurement of what that consumption actually achieves in terms of speed or distance travelled. This can significantly weaken our ability to link metabolic rates to ecological processes, and may explain why conventional measures of metabolic rate often do not predict performance or fitness. This ambitious project will therefore attempt to re-dress the balance by shifting the focus onto the efficiency with which mitochondria produce ATP, with the expectation that this will lead to completely new insights into how metabolic rate influences and constrains the behaviour and ecology of animals. It will use new techniques that we have developed for simultaneous measurement of both ATP and ROS production by the mitochondria; these have revealed two-fold variation among individuals in the efficiency of ATP production (and hence ability to perform aerobic work), totally hidden from usual measurements of metabolic rate. I will use these approaches to examine the impact of metabolic efficiency on performance and the trade-off between efficiency and rates of senescence, using freshwater fish as an experimental system. By applying cutting-edge methods, so far only used in the laboratory, to animals living in their natural habitats, the project will reveal for the first time how environmental conditions select for particular mitochondrial phenotypes and hence metabolic efficiency, so allowing a re-evaluation of the links between ecology and metabolic rate.

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The information about "MITOWILD" are provided by the European Opendata Portal: CORDIS opendata.

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