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MitoWild SIGNED

Counting the cost of living: mitochondrial efficiency, environmental conditions, and performance in the wild

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

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 MitoWild project word cloud

Explore the words cloud of the MitoWild project. It provides you a very rough idea of what is the project "MitoWild" about.

travelled    fitness    mitochondria    significantly    attempt    measuring    weaken    instead    laboratory    totally    links    techniques    hidden    ros    consumption    environmental    constrains    insights    evaluation    textbook    generally    edge    aerobic    minute    revealed    time    record    individuals    achieves    expectation    variation    natural    speed    examine    re    living    car    efficiency    ecological    reveal    performance    energy    equivalent    link    an    select    balance    fish    definitions    fuel    trait    estimating    capacity    perform    influences    atp    physiology    life    fold    phenotypes    mitochondrial    completely    conventional    usual    organism    experimental    distance    conceptual    predict    history    animals    trade    simultaneous    empirical    central    metabolic    indirectly    oxygen    shifting    animal    cutting    freshwater    actually    habitats    contains    senescence    weakness    ecology    rate    dress    rates    first    onto    actual    off    refer    hence   

Project "MitoWild" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF GLASGOW 

Organization address
address: UNIVERSITY AVENUE
city: GLASGOW
postcode: G12 8QQ
website: www.gla.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙445˙128 €
 EC max contribution 2˙445˙128 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF GLASGOW UK (GLASGOW) coordinator 2˙445˙128.00

Map

 Project objective

An organism’s metabolic rate is a central trait that links its physiology with its ecology and life history. However, while textbook definitions of metabolic rate generally refer to the rate of energy use by the animal, most empirical studies instead record it very indirectly as whole-animal oxygen consumption rate, without any actual measurement of ATP production. This approach contains a conceptual weakness: it is equivalent to estimating a car’s capacity or efficiency by measuring its fuel consumption per minute, with no measurement of what that consumption actually achieves in terms of speed or distance travelled. This can significantly weaken our ability to link metabolic rates to ecological processes, and may explain why conventional measures of metabolic rate often do not predict performance or fitness. This ambitious project will therefore attempt to re-dress the balance by shifting the focus onto the efficiency with which mitochondria produce ATP, with the expectation that this will lead to completely new insights into how metabolic rate influences and constrains the behaviour and ecology of animals. It will use new techniques that we have developed for simultaneous measurement of both ATP and ROS production by the mitochondria; these have revealed two-fold variation among individuals in the efficiency of ATP production (and hence ability to perform aerobic work), totally hidden from usual measurements of metabolic rate. I will use these approaches to examine the impact of metabolic efficiency on performance and the trade-off between efficiency and rates of senescence, using freshwater fish as an experimental system. By applying cutting-edge methods, so far only used in the laboratory, to animals living in their natural habitats, the project will reveal for the first time how environmental conditions select for particular mitochondrial phenotypes and hence metabolic efficiency, so allowing a re-evaluation of the links between ecology and metabolic rate.

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The information about "MITOWILD" are provided by the European Opendata Portal: CORDIS opendata.

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