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LinkFM SIGNED

Linking Functional impact and Microstructural properties of fiber tract demyelination and remyelination in a rodent model of multiple sclerosis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 LinkFM project word cloud

Explore the words cloud of the LinkFM project. It provides you a very rough idea of what is the project "LinkFM" about.

disentangle    monitoring    propagation    mri    exact    yield    model    ing    neuroinflammation    create    relationship    cell    sclerosis    primary    prospectively    central    inflammatory    repair    trigger    patients    brain    connected    degeneration    disease    impairing    diffusion    quantitative    myelin    neuronal    diffuse    leveraging    integration    nervous    membrane    framework    amount    voltage    circuits    expertise    biomarkers    sensitive    dysfunction    blocks    reparatory    wrapped    perform    biophysical    integrates    bridge    myelination    axon    dynamics    personalized    ms    optimize    scales    axons    inter    temporal    microstructural    functional    network    content    calcium    intracellular    multimodal    building    cortical    remyelination    sequences    drcmr    connectivity    lines    white    trace    optogenetics    tract    resting    destroys    leads    rat    de    combine    models    lesioned    delays    sheaths    tracts    parallel    damage    cellular    informing    diameter    optimized    poorly    trans    re    mr    simultaneous    axonal    multiple    mapping    myelinisation    demyelination    signal    treatment    neurodegenerative    recording   

Project "LinkFM" data sheet

The following table provides information about the project.

Coordinator
REGION HOVEDSTADEN 

Organization address
address: KONGENS VAENGE 2
city: HILLEROD
postcode: 3400
website: www.regionh.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 219˙312 €
 EC max contribution 219˙312 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    REGION HOVEDSTADEN DK (HILLEROD) coordinator 219˙312.00

Map

 Project objective

Multiple sclerosis (MS) is a diffuse inflammatory and neurodegenerative disease of the central nervous system. Neuroinflammation destroys the myelin sheaths wrapped around the axons and may lead to axon degeneration. Repair processes trigger re-myelinisation. Myelin loss delays or blocks signal propagation along axons in white matter tracts, impairing neuronal integration within the affected brain network. The exact relationship between the amount of axonal de- and re-myelination and the resulting network dysfunction is still poorly understood. Using a rat MS model, I will bridge the scales from the cellular to the network level, to disentangle how myelin loss and axonal degeneration leads to network dysfunction. My approach integrates three lines of research: (i) I will prospectively perform diffusion MRI and quantitative MRI to assess the temporal dynamics of microstructural changes in axon diameter and myelin content in the lesioned white matter tract. Leveraging state-of-art expertise at DRCMR, I will optimize MR sequences and biophysical models to create an optimized axon diameter and myelin mapping framework. (ii) In parallel, I will perform resting-state and task-based functional MRI to trace the resulting changes in functional connectivity at the network level. (iii) Building on my expertise, I will combine functional MRI with optogenetics and simultaneous intracellular calcium (and trans-membrane voltage) recording to characterize in detail the functional impact of axonal damage in the lesioned white matter tract on well-defined cell circuits in the inter-connected cortical areas. This unique multimodal approach will yield novel MRI-based biomarkers that are sensitive and specific to primary demyelination and axonal degeneration on the one hand and reparatory processes such as remyelination on the other hand. These biomarkers will have great potential for monitoring disease activity, informing personalized treatment in patients with MS.

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The information about "LINKFM" are provided by the European Opendata Portal: CORDIS opendata.

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