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SynapSeek SIGNED

Learning the shape of synaptic plasticity rules for neuronal architectures and function through machine learning.

Total Cost €

0

EC-Contrib. €

0

Partnership

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 SynapSeek project word cloud

Explore the words cloud of the SynapSeek project. It provides you a very rough idea of what is the project "SynapSeek" about.

brain    structures    representative    computational    connectivity    synapseek    unknown    utilizing    complexity    basic    cortical    chess    game    newly    deep    canonical    strengthen    connection    flexible    accordingly    neural    first    protocols    plasticity    questions    progress    simulations    go    instrument    measuring    circuit    data    extraordinary    governed    similarly    time    synaptic    sheer    incorporate    learning    answer    network    expression    silico    environment    building    changing    play    machine    shape    ranging    integrate    algorithms    mode    meant    additional    memory    appropriate    framework    stereotypically    power    handful    triggered    largely    limited    reliably    deduce    rules    stimulation    observing    slow    mechanisms    synapses    monitor    function    experimentally    weaken    dance    mathematical    constraints    interference    operation    difficulty    search    how    circuits    published    types    infer    structure    dubbed    hundred   

Project "SynapSeek" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙798˙605 €
 EC max contribution 1˙798˙605 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2024-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 1˙798˙605.00

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 Project objective

How do we learn to dance, play an instrument, or a game as complex as chess or go? How do we make a memory? The common answer to these questions is “through synaptic plasticity”, through changing the synaptic connectivity of neural circuits so that representative brain activity can be reliably triggered. Such connectivity changes are governed by rules, i.e., synaptic mechanisms which monitor the activity of their environment and stereotypically strengthen or weaken synapses accordingly. The shape and mode of operation of these rules is still largely unknown: For the more than hundred different connection types in cortical circuits, only a handful of rules has been described at all. Similarly, testing observed rules in simulations of cortical function has only seen limited success. Our slow progress is due to the extraordinary difficulty of measuring and observing synapses without interference.

Here, we propose a new approach. By utilizing the growing power of machine learning methods we can deduce synaptic plasticity rules directly. Newly developed search algorithms and sheer computational power allow us to integrate published data and infer synaptic rules in silico. We aim to (1) develop a new mathematical expression of synaptic plasticity rules, experimentally appropriate and flexible enough to be implemented in a Machine Learning framework, dubbed SYNAPSEEK. Next (2), we will apply SYNAPSEEK to deduce the rules for building various neural structures with increasing complexity. Finally (3), we will incorporate additional constraints to SYNAPSEEK to develop synaptic rules that shape network function as much as its structure. Our work will establish, for the first time, canonical sets of synaptic plasticity rules, based on the circuit structure they must produce, and the function they are meant to support. SYNAPSEEK will have immediate and wide ranging applications, from a basic understanding of cortical development to better protocols for Deep Brain Stimulation.

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The information about "SYNAPSEEK" are provided by the European Opendata Portal: CORDIS opendata.

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