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INTEGROMED SIGNED

Integration of knowledge and biobank resources in comprehensive translational approach for personalized prevention and treatment of metabolic disorders

Total Cost €

EC-Contrib. €

Partnership

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INTEGROMED project word cloud

Explore the words cloud of the INTEGROMED project. It provides you a very rough idea of what is the project "INTEGROMED" about.

disorders internationally ecosystem specialists elaborate workflow omics mentoring bioinformatics opportunity entrepreneurial virtually profile reaching training technologies stakeholders clinicians accomplished university network establishment biobanks sustainability health biobank latvia combination national cutting metabolic cohorts skills bedside methylation outcomes lbmc integrate area strengthen entrepreneurism dundee prospective integromed translational weizmann exchange precision care innovation clinical lund excellence integration systemic genomics implementing medicine strategy microbiome strategies edge plan stuff expression optimize diabetes science practical larger metabolome sustainable optimal

Project "INTEGROMED" data sheet

The following table provides information about the project.

Coordinator	LATVIJAS BIOMEDICINAS PETIJUMU UN STUDIJU CENTRS Organization address address: RATSUPITES IELA 1 city: RIGA postcode: 1067 website: http://bmc.biomed.lu.lv/en/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Latvia [LV]
Total cost	800˙000 €
EC max contribution	800˙000 € (100%)
Programme	1. H2020-EU.4.b. (Twinning of research institutions)
Code Call	H2020-WIDESPREAD-2018-03
Funding Scheme	CSA
Starting year	2019
Duration (year-month-day)	from 2019-10-01 to 2022-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	LATVIJAS BIOMEDICINAS PETIJUMU UN STUDIJU CENTRS LATVIJAS BIOMEDICINAS PETIJUMU UN STUDIJU CENTRS Organization address address: RATSUPITES IELA 1 city: RIGA postcode: 1067 website: http://bmc.biomed.lu.lv/en/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	LV (RIGA)	coordinator	350˙000.00
2	LUNDS UNIVERSITET LUNDS UNIVERSITET Organization address address: Paradisgatan 5c city: LUND postcode: 22100 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (LUND)	participant	150˙000.00
3	UNIVERSITY OF DUNDEE UNIVERSITY OF DUNDEE Organization address address: Nethergate city: DUNDEE postcode: DD1 4HN website: www.dundee.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (DUNDEE)	participant	150˙000.00
4	WEIZMANN INSTITUTE OF SCIENCE WEIZMANN INSTITUTE OF SCIENCE Organization address address: HERZL STREET 234 city: REHOVOT postcode: 7610001 website: www.weizmann.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (REHOVOT)	participant	150˙000.00

Map

Project objective

INTEGROMED is aiming to provide LBMC with the opportunity to integrate the experience of research excellence institutions and existing resources by creating a research and innovation network with three internationally leading organizations in the translational medicine area – University of Dundee, Lund University, and Weizmann Institute of Science. The strategy of INTEGROMED is to increase excellence and develop sustainable approach targeting virtually all aspects of translational medicine including the optimal use of clinical and biobank resources, integration of different omics in systemic workflow, reaching development of bedside applications and fostering entrepreneurism. Project has a strong focus on study of metabolic disorders including type 2 diabetes, however the training, mentoring and stuff exchange activities as well as practical outcomes will be available for other fields including researchers, clinicians and other stakeholders in Latvia, promoting the implementation of the developed strategies at larger scale. The result of project will be accomplished by following three main objectives. (1) To improve and optimize the use of resources provided by large biobanks and prospective cohorts in combination with national health care system, improve knowledge in establishment of clinical studies for development of precision medicine approaches. (2) To strengthen collaboration-based training of specialists in areas of multi-omics approaches, bioinformatics, and modelling to increase excellence in implementing cutting edge multi omics technologies in such areas as genomics, methylation and expression profile, microbiome and metabolome analysis. (3) To elaborate a long-term strategy and sustainability plan involving all relevant stakeholders, ensure development and training in clinical applications and entrepreneurial skills to build an innovation ecosystem around LBMC.

Publications

List of publications.
year	authors and title	journal	last update
2018	Ilze Elbere, Ivars Silamikelis, Monta Ustinova, Ineta Kalnina, Linda Zaharenko, Raitis Peculis, Ilze Konrade, Diana Maria Ciuculete, Christina Zhukovsky, Dita Gudra, Ilze Radovica-Spalvina, Davids Fridmanis, Valdis Pirags, Helgi B. SchiÃ¶th, Janis Klovins Significantly altered peripheral blood cell DNA methylation profile as a result of immediate effect of metformin use in healthy individuals published pages: , ISSN: 1868-7075, DOI: 10.1186/s13148-018-0593-x	Clinical Epigenetics 10/1	2019-12-16
2019	Dita Gudra, Saeed Shoaie, Davids Fridmanis, Janis Klovins, Hugo Wefer, Ivars Silamikelis, Raitis Peculis, Ineta Kalnina, Ilze Elbere, Ilze Radovica-Spalvina, Rolf Hultcrantz, Ä¢irts Å Ä·enders, Marcis Leja, Lars Engstrand A widely used sampling device in colorectal cancer screening programmes allows for large-scale microbiome studies published pages: 1723-1725, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2018-316225	Gut 68/9	2019-12-16
2018	Mikhail Baryshev, Inna Inashkina, Kristine Salmina, Anda Huna, Thomas R Jackson, Jekaterina Erenpreisa DNA methylation of the Oct4A enhancers in embryonal carcinoma cells after etoposide treatment is associated with alternative splicing and altered pluripotency in reversibly senescent cells published pages: 362-366, ISSN: 1538-4101, DOI: 10.1080/15384101.2018.1426412	Cell Cycle 17/3	2019-12-16
2016	Linda Zaharenko, Ineta Kalnina, Kristine Geldnere, Ilze Konrade, Solveiga Grinberga, Jozef Å½idzik, Martin JavorskÃ½, Aivars Lejnieks, Liene Nikitina-Zake, Davids Fridmanis, Raitis Peculis, Ilze Radovica-Spalvina, Dace Hartmane, Osvalds Pugovics, Ivan TkÃ¡Ä, Lucia KlimÄÃ¡kovÃ¡, Valdis PÄ«rÄgs, Janis Klovins Single nucleotide polymorphisms in the intergenic region between metformin transporter OCT2 and OCT3 coding genes are associated with short-term response to metformin monotherapy in type 2 diabetes mellitus patients published pages: 531-540, ISSN: 0804-4643, DOI: 10.1530/eje-16-0347	European Journal of Endocrinology 175/6	2019-12-16
2018	Ilze Elbere, Ineta Kalnina, Ivars Silamikelis, Ilze Konrade, Linda Zaharenko, Kristine Sekace, Ilze Radovica-Spalvina, Davids Fridmanis, Dita Gudra, Valdis Pirags, Janis Klovins Association of metformin administration with gut microbiome dysbiosis in healthy volunteers published pages: e0204317, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0204317	PLOS ONE 13/9	2019-12-16
2018	Vita Rovite, Yael Wolff-Sagi, Linda Zaharenko, Liene Nikitina-Zake, Elmars Grens, Janis Klovins Genome Database of the Latvian Population (LGDB): Design, Goals, and Primary Results published pages: 353-360, ISSN: 0917-5040, DOI: 10.2188/jea.je20170079	Journal of Epidemiology 28/8	2019-12-16
2019	Monta Ustinova, Ivars Silamikelis, Ineta Kalnina, Laura Ansone, Vita Rovite, Ilze Elbere, Ilze Radovica-Spalvina, Davids Fridmanis, Jekaterina Aladyeva, Ilze Konrade, Valdis Pirags, Janis Klovins Metformin strongly affects transcriptome of peripheral blood cells in healthy individuals published pages: e0224835, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0224835	PLOS ONE 14/11	2019-12-16

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