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SCilS SIGNED

Studying Ciliary Signaling in Development and Disease

Total Cost €

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EC-Contrib. €

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Partnership

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 SCilS project word cloud

Explore the words cloud of the SCilS project. It provides you a very rough idea of what is the project "SCilS" about.

regulation    proteomics    output    uncover    multidisciplinary    industry    super    thereby    organoid    integrating    organization    outstanding    bioinformatics    secondments    training    broad    intersectoral    imaging    settings    sectors    genetic    cells    give    tomography    ciliary    tissues    academic    primary    interventions    accomplished    electron    degree    designed    robustness    critical    of    industrial    attractive    academia    therapeutic    human    signalling    overlapping    severe    structural    majority    network    dysfunctional    scils    400    understand    prospects    public    segregate    microtubule    unparalleled    career    individual    cutting    organs    ciliopathy    traits    expertise    zebrafish    cellular    models    edge    concentrate    projections    cryo    phenotypes    hubs    35    biochemistry    biology    signaling    ciliopathies    cilia    mediated    private    efficient    disease    stem    genomics    people    components    surface    homeostasis    gt    stage    heterogeneous    competences    resolution    create    esr    cell    esrs    feedback    sessions    unavailable    etiology   

Project "SCilS" data sheet

The following table provides information about the project.

Coordinator		 STICHTING KATHOLIEKE UNIVERSITEIT 

Organization address
address: GEERT GROOTEPLEIN NOORD 9
city: NIJMEGEN
postcode: 6525 EZ
website: www.radboudumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Netherlands [NL]
 Total cost 3˙844˙874 €
 EC max contribution 3˙844˙874 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2019
 Funding Scheme MSCA-ITN-ETN
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) coordinator 531˙239.00
2    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) participant 892˙566.00
3    IMAGINE INSTITUT DES MALADIES GENETIQUES NECKER ENFANTS MALADES FONDATION FR (PARIS 15) participant 549˙604.00
4    NEWCELLS BIOTECH LIMITED UK (NEWCASTLE UPON TYNE) participant 303˙172.00
5    AARHUS UNIVERSITET DK (AARHUS C) participant 297˙522.00
6    OSPEDALE SAN RAFFAELE SRL IT (MILANO) participant 261˙499.00
7    CELL NETWORKS GMBH DE (HEIDELBERG) participant 252˙788.00
8    EBERHARD KARLS UNIVERSITAET TUEBINGEN DE (TUEBINGEN) participant 252˙788.00
9    RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG DE (HEIDELBERG) participant 252˙788.00
10    ZECLINICS SL ES (BARCELONA) participant 250˙904.00

Map

 Project objective

SCilS will create a multidisciplinary and intersectoral European training network focusing on ciliary signalling in development and disease. Primary cilia are microtubule-based cell surface projections that have evolved to be key signalling hubs of our cells, as they concentrate or segregate components of major cellular signalling pathways. Control of ciliary signaling output requires a high degree of regulation and critical feedback, which is needed for robustness in development and cellular homeostasis of different tissues and organs. Dysfunctional cilia can therefore lead to >35 severe human genetic traits (ciliopathies) with highly heterogeneous, overlapping phenotypes. Ciliopathies affect as many as 1 in 400 people, and for the majority of cases efficient therapeutic interventions are currently unavailable. SCilS research aims to uncover the multi-level organization and regulation of cilia-mediated signalling pathways in order to understand ciliopathy disease etiology and identify novel therapeutic targets. This challenging task will be accomplished by integrating unique expertise and cutting edge technology available within the SCilS network, including structural biology, super resolution imaging and cryo-electron tomography, state-of-the-art genomics, proteomics and bioinformatics, (stem) cell biology and biochemistry, as well as organoid technology and zebrafish models. SCilS training will give Early Stage Researchers (ESRs) unparalleled training opportunities in outstanding academic and industrial settings through training-by-research via individual research projects, secondments, and network-wide training sessions. All individual training and research activities have been designed to provide each ESR with the necessary broad competences in state‐of‐the art academic and industrial research. The network will thereby make a career in both industry and academia attractive to the ESRs and improve their career prospects in both private and public sectors.

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The information about "SCILS" are provided by the European Opendata Portal: CORDIS opendata.

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