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DynAMic SIGNED

Dynamic adaptive microscopy for label-free multi-parametric imaging in biology and medicine

Total Cost €

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EC-Contrib. €

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Partnership

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 DynAMic project word cloud

Explore the words cloud of the DynAMic project. It provides you a very rough idea of what is the project "DynAMic" about.

fundamental    lt    spectrally    sensitivity    proteomic    label    agendi    ideal    contrast    labels    medical    tissue    radically    invasive    deeper    genomics    proteins    expands    diffusing    proposes    variations    inversing    reaching    operandi    shaping    first    interrogations    limitations    concurrently    retrieval    vivo    devastating    least    conventional    index    observation    diffusion    probes    modus    generation    biological    propagation    ophthalmic    disturbing    few    nervous    performance    stimulated    compensating    light    constitutes    detection    proteomics    disease    superficial    mean    image    dynamic    tenfold    multiplexing    imaging    monitoring    fluorescent    delivered    nature    linking    optics    ophthalmology    free    optical    brain    paradigms    paths    depths    random    retinal    visualization    refractive    sensing    incompatible    time    utilize    fluorochromes    polarization    wavefront    disrupting    events    regard    limits    1mm    adaptive    parametric    living    retrieved    window    raman    neurology    functional    scattering    microscopy   

Project "DynAMic" data sheet

The following table provides information about the project.

Coordinator
IDRYMA TECHNOLOGIAS KAI EREVNAS 

Organization address
address: N PLASTIRA STR 100
city: IRAKLEIO
postcode: 70013
website: www.forth.gr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Total cost 3˙957˙137 €
 EC max contribution 3˙957˙137 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IDRYMA TECHNOLOGIAS KAI EREVNAS EL (IRAKLEIO) coordinator 605˙000.00
2    TECHNISCHE UNIVERSITAET MUENCHEN DE (MUENCHEN) participant 697˙092.00
3    THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS UK (ST ANDREWS) participant 649˙316.00
4    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) participant 597˙296.00
5    IMAGINE OPTIC FR (ORSAY) participant 498˙900.00
6    RAYFOS LTD UK (BASINGSTOKE) participant 493˙657.00
7    EBERHARD KARLS UNIVERSITAET TUEBINGEN DE (TUEBINGEN) participant 415˙875.00

Map

 Project objective

Optical microscopy constitutes one of the most fundamental paradigms in biological and medical imaging. However, significant challenges remain in regard to the application of optical microscopy to in vivo interrogations. First, the diffusing nature of light propagation in tissue due to random variations of the refractive index, limits in vivo microscopy to superficial depths; within only a few mean free paths (<1mm). Second the invasive nature of fluorescent proteins and probes, allows monitoring of only 1-5 events by spectrally multiplexing different fluorochromes; i.e. performance that is highly incompatible with the targets of functional genomics and proteomics. This proposal aims to develop the next step in optical visualization by addressing these two fundamental limitations of optical imaging, i.e. Depth and Contrast. To achieve this, DynAMic proposes a radically new concept for optical imaging of tissue based on ❶ developing real-time wavefront-shaping adaptive optics for making the performance of any optical system ideal and for the first time in Raman microscopy ❷ reaching tenfold deeper in tissue than conventional optical microscopy by compensating for the refractive index variations using phase and polarization retrieval for inversing light diffusion and ❸ utilize advance image formation to improve the sensitivity and utilization of stimulated Raman scattering for multi-parametric label-free contrast that radically expands at least tenfold the number of labels concurrently retrieved from living systems, linking optical observation to functional proteomic requirements. The new optical imaging ability delivered in DynAMic will be applied to a first target application of ophthalmic imaging, also used as a window to the brain and devastating nervous disease detection, defining the next generation ophthalmology and neurology sensing, disrupting the modus operandi of retinal imaging without disturbing the modus agendi of the end users.

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The information about "DYNAMIC" are provided by the European Opendata Portal: CORDIS opendata.

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