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CRUCIAL SIGNED

MiCrovasculaR rarefaction in vascUlar Cognitive Impairement and heArt faiLure

Total Cost €

EC-Contrib. €

Partnership

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CRUCIAL project word cloud

Explore the words cloud of the CRUCIAL project. It provides you a very rough idea of what is the project "CRUCIAL" about.

hypertension diabetes coordinated patients therapeutic disorder blood heart brain cardiac ultimately morbidity artificial comorbidities impairment tools crucual animal stresses rarefaction advantage limited density retrospective disease mechanism regression treating inability clinical invasive chronic stratify molecular recognised patient biomarker mri clinician models dementia prospective therapeutically vascular mortality techniques burden contrast quality progression options cheaper diagnosis retinal diagnose aging induce diagnostic imaging newest cohorts ing disseminate sublingual sensitive reduce life mental pharma organs intelligence health vessel co microvascular microvesicle active cognitive easier prevent morbidities

Project "CRUCIAL" data sheet

The following table provides information about the project.

Coordinator	KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: OUDE MARKT 13 city: LEUVEN postcode: 3000 website: www.kuleuven.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Belgium [BE]
Total cost	6˙000˙000 €
EC max contribution	6˙000˙000 € (100%)
Programme	1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
Code Call	H2020-SC1-2019-Two-Stage-RTD
Funding Scheme	RIA
Starting year	2020
Duration (year-month-day)	from 2020-01-01 to 2023-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KATHOLIEKE UNIVERSITEIT LEUVEN KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: OUDE MARKT 13 city: LEUVEN postcode: 3000 website: www.kuleuven.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LEUVEN)	coordinator	1˙340˙553.00
2	UNIVERSITEIT MAASTRICHT UNIVERSITEIT MAASTRICHT Organization address address: Minderbroedersberg 4-6 city: MAASTRICHT postcode: 6200 MD website: http://www.maastrichtuniversity.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (MAASTRICHT)	participant	1˙465˙843.00
3	UNIVERSITY COLLEGE LONDON UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	949˙470.00
4	VIB VIB Organization address address: RIJVISSCHESTRAAT 120 city: ZWIJNAARDE - GENT postcode: 9052 website: www.vib.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (ZWIJNAARDE - GENT)	participant	777˙630.00
5	FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA Organization address address: AVENIDA DE PIO XII 55 city: PAMPLONA postcode: 31008 website: www.cima.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (PAMPLONA)	participant	459˙505.00
6	UNIVERSIDAD DE NAVARRA UNIVERSIDAD DE NAVARRA Organization address address: CAMPUS UNIVERSITARIO EDIFICIO CENTRAL city: PAMPLONA postcode: 31080 website: www.unav.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (PAMPLONA)	participant	345˙495.00
7	ARTTIC ARTTIC Organization address address: RUE DU DESSOUS DES BERGES 58A city: PARIS postcode: 75013 website: www.arttic.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	227˙250.00
8	GLYCOCHECK BV GLYCOCHECK BV Organization address address: GROOT HAASDAL 3 city: SCHIMMERT postcode: 6333 AV website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (SCHIMMERT)	participant	133˙000.00
9	INLECOM INNOVATION ASTIKI MI KERDOSKOPIKI ETAIREIA INLECOM INNOVATION ASTIKI MI KERDOSKOPIKI ETAIREIA Organization address address: TATOIOU 11 KIFISSIA city: ATHINA postcode: 145 61 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (ATHINA)	participant	131˙252.00
10	CROWDHELIX LIMITED CROWDHELIX LIMITED Organization address address: TRINITY HOUSE 7 GEORGES QUAY city: CORK postcode: T12NAX0 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (CORK)	participant	130˙000.00
11	BRAINS UNLIMITED B.V. / TRADE NAME SCANNEXUS BRAINS UNLIMITED B.V. / TRADE NAME SCANNEXUS Organization address address: OXFORDLAAN 55 city: MAASTRICHT postcode: 6229 EV website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (MAASTRICHT)	participant	20˙000.00
12	CARDIOMYOPATHY UK CARDIOMYOPATHY UK Organization address address: UNIT 10 CHILTERN COURT ASHERIDGE ROAD city: CHESHAM postcode: HP5 2PX website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CHESHAM)	participant	20˙000.00

Map

Project objective

Vascular dementia and heart failure represent major health burden to morbidity, mortality and quality of life. Comorbidities (hypertension, aging, diabetes, etc.) affect all organs, but the brain and heart are especially sensitive to these chronic stresses resulting in cognitive impairment (a mental disorder) and heart failure (a non-mental disorder). These comorbidities also induce a reduction in microvascular density, called microvascular rarefaction. We have build a consortium, CRUCIAL, which will develop a coordinated program to investigate the role of microvascular rarefaction in cognitive impairment and heart failure.

Diagnosis of microvascular rarefaction is limited by the inability to assess microvascular density. We will develop advanced imaging tools taking advantage of the newest MRI technology including non-contrast and artificial intelligence methods to assess brain and heart microvascular rarefaction. We will also develop other non-invasive measures that will be cheaper and easier to widely disseminate in clinical practice (sublingual and retinal microvascular imaging, and blood microvesicle analysis). We will then apply these techniques to prospective and retrospective patient cohorts with cognitive impairment and heart failure to demonstrate that rarefaction can be used as a biomarker to diagnose and stratify patients. Microvascular regression is now recognised as an active process. We will therefore investigate, through animal models, the molecular mechanism of vessel rarefaction in the presence of comorbidities that could be targeted therapeutically.

Therapeutic options for cognitive impairment or heart failure are currently limited to treating co-morbidities. The aim of CRUCUAL is to deliver diagnostic tools to clinician and therapeutic pathways to pharma that target microvascular health in order to prevent cognitive and cardiac disease progression, reduce morbidity and ultimately improve quality of life for patients.

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The information about "CRUCIAL" are provided by the European Opendata Portal: CORDIS opendata.