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INCENTIVE SIGNED

Indo-European Consortium for Next Generation Influenza Vaccine Innovation

Total Cost €

EC-Contrib. €

Partnership

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INCENTIVE project word cloud

Explore the words cloud of the INCENTIVE project. It provides you a very rough idea of what is the project "INCENTIVE" about.

seminal reduce india human comprising strategic acid predictive performing vaccines immunological underlying ing transfer pursing universal responsiveness true antigen reactive cell influenza nucleic profiling income proof perform children harmonization immunome technologies goals health efficacy worldwide investment vaccine populations infections integration data downstream vulnerable optimized poor responders trials computationally incentive posed discrete groups clinical model cobra antigens adults suitability countries outbreaks experiments biomarkers infants individuals mechanisms global vaccination trial licensed generation indian parallel burden primates gap constraints partnership middle care economic presenting diagnostics broadly ethnical elderly

Project "INCENTIVE" data sheet

The following table provides information about the project.

Coordinator	HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH Organization address address: INHOFFENSTRASSE 7 city: BRAUNSCHWEIG postcode: 38124 website: www.helmholtz-hzi.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Total cost	19˙965˙992 €
EC max contribution	9˙974˙293 € (50%)
Programme	1. H2020-EU.3.1.2. (Preventing disease)
Code Call	H2020-SC1-2019-Single-Stage-RTD
Funding Scheme	RIA
Starting year	2020
Duration (year-month-day)	from 2020-04-01 to 2025-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH Organization address address: INHOFFENSTRASSE 7 city: BRAUNSCHWEIG postcode: 38124 website: www.helmholtz-hzi.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BRAUNSCHWEIG)	coordinator	2˙537˙797.00
2	ACADEMISCH ZIEKENHUIS LEIDEN ACADEMISCH ZIEKENHUIS LEIDEN Organization address address: ALBINUSDREEF 2 city: LEIDEN postcode: 2333 ZA website: www.lumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	1˙003˙785.00
3	UNIVERSITEIT ANTWERPEN UNIVERSITEIT ANTWERPEN Organization address address: PRINSSTRAAT 13 city: ANTWERPEN postcode: 2000 website: www.ua.ac.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (ANTWERPEN)	participant	919˙943.00
4	STICHTING HUMAN VACCINES PROJECT EUROPE STICHTING HUMAN VACCINES PROJECT EUROPE Organization address address: BRAKERSWEG 53 city: CASTRICUM postcode: 1901 XX website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (CASTRICUM)	participant	794˙312.00
5	HUMAN VACCINES PROJECT, INC HUMAN VACCINES PROJECT, INC Organization address address: 251 LITTLE FALLS DRIVE city: WILMINGTON NEW CASTLE postcode: 19808 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (WILMINGTON NEW CASTLE)	participant	760˙705.00
6	UNIVERSITE LIBRE DE BRUXELLES UNIVERSITE LIBRE DE BRUXELLES Organization address address: AVENUE FRANKLIN ROOSEVELT 50 city: BRUXELLES postcode: 1050 website: www.ulb.ac.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BRUXELLES)	participant	614˙963.00
7	UGA RESEARCH FOUNDATION INC NON PROFIT CORP UGA RESEARCH FOUNDATION INC NON PROFIT CORP Organization address address: 150D PAUL D. COVERDELL CENTER 500 DW BROOKS DRIVE city: ATHENS postcode: 30602-7411 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (ATHENS)	participant	586˙990.00
8	UNIVERSITETET I BERGEN UNIVERSITETET I BERGEN Organization address address: MUSEPLASSEN 1 city: BERGEN postcode: 5020 website: www.uib.no contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (BERGEN)	participant	567˙296.00
9	BIOASTER FONDATION DE COOPERATION SCIENTIFIQUE BIOASTER FONDATION DE COOPERATION SCIENTIFIQUE Organization address address: 40 AVENUE TONY GARNIER city: LYON postcode: 69007 website: www.bioaster.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (LYON)	participant	531˙858.00
10	INSTITUT PASTEUR INSTITUT PASTEUR Organization address address: RUE DU DOCTEUR ROUX 25-28 city: PARIS CEDEX 15 postcode: 75724 website: http://www.pasteur.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS CEDEX 15)	participant	441˙260.00
11	ASA SPEZIALENZYME GMBH ASA SPEZIALENZYME GMBH Organization address address: AM EXER 19 C city: WOLFENBUTTEL postcode: 38302 website: www.asa-enzyme.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (WOLFENBUTTEL)	participant	387˙750.00
12	FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA Organization address address: C ROSSELLO 132 PLANTA 05 city: BARCELONA postcode: 8036 website: www.isglobal.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	383˙670.00
13	UNIVERSITETET I OSLO UNIVERSITETET I OSLO Organization address address: PROBLEMVEIEN 5-7 city: OSLO postcode: 313 website: www.uio.no contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (OSLO)	participant	307˙086.00
14	EUROVACC FOUNDATION EUROVACC FOUNDATION Organization address address: PLACE SAINT-FRANCOIS 1 ETUDE KELLERHALS CARRARD city: LAUSANNE postcode: 1003 website: www.eurovacc.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (LAUSANNE)	participant	136˙875.00
15	INDIAN INSTITUTE OF TECHNOLOGY MADRAS (IITM) INDIAN INSTITUTE OF TECHNOLOGY MADRAS (IITM) Organization address address: Centre for Industrial Consultancy and Sponsored Research Indian Institute if Technology Madras city: Chennai postcode: 600036 website: www.iitm.ac.in contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IN (Chennai)	participant	0.00
16	NATIONAL INSTITUTE OF IMMUNOLOGY SOCIETY NATIONAL INSTITUTE OF IMMUNOLOGY SOCIETY Organization address address: ARUNA ASAF ALI MARG city: NEW DELHI postcode: 110067 website: www.nii.res.in contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IN (NEW DELHI)	participant	0.00
17	PUBLIC HEALTH FOUNDATION OF INDIA PUBLIC HEALTH FOUNDATION OF INDIA Organization address address: ISID Campus, 4th Institutional Area, Vasant Kunj city: NEW DELHI postcode: 110070 website: www.phfi.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IN (NEW DELHI)	participant	0.00
18	SETH G S M COLLEGE AND K E M HOSPITAL DIAMOND JUBILEE SOCIETY SETH G S M COLLEGE AND K E M HOSPITAL DIAMOND JUBILEE SOCIETY Organization address address: ACHARYA DONDE MARG PAREL city: MUMBAI postcode: 400012 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IN (MUMBAI)	participant	0.00
19	TRANSLATIONAL HEALTH SCIENCE AND TECHNOLOGY INSTITUTE TRANSLATIONAL HEALTH SCIENCE AND TECHNOLOGY INSTITUTE Organization address address: NCR BIOTECH SCIENCE CLUSTER 3RD MILESTONE HARYANA city: FARIDABAD postcode: 121001 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IN (FARIDABAD)	participant	0.00

Map

Project objective

The highly integrated INCENTIVE consortium represents true partnership between Indian and European/US groups that addresses the global health and economic challenge posed by influenza infections, to reduce the worldwide burden resulting from outbreaks. INCENTIVE’s strategic goals are to provide seminal knowledge on the underlying mechanisms of poor responsiveness to influenza vaccines in vulnerable individuals and advance the development of two next generation universal influenza vaccines. This is achieved by pursing the following specific objectives: 1) address the current knowledge gap by performing comprehensive immunome profiling of responders and non-responders to licensed influenza vaccines in infants, children, adults and elderly in parallel phase IV trials in Europe and India to identify the underlying mechanisms of vaccine responsiveness in different vulnerable populations and ethnical groups; 2) advance the development of two next generation universal vaccines, including an antigen presenting cell-targeted nucleic acid vaccine up to proof-of-concept for vaccine efficacy in non-human primates, and a computationally-derived second generation COBRA (Computationally-Optimized Broadly-Reactive Antigens) vaccine up to clinical development, comprising a phase I trial in Europe, a phase II trial in India and efficacy studies using an influenza controlled human challenge model; 3) identify predictive biomarkers of responsiveness to vaccination to develop new diagnostics; 4) implement comprehensive technology transfer and harmonization activities for immunological analysis and data integration; and 5) perform a health systems and investment analysis, and discrete choice experiments to assess the suitability of the developed technologies for low- and middle-income countries and to identify potential downstream constraints that might affect uptake by health care systems.

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