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EXECUT.ER SIGNED

Dissecting the molecular mechanisms that execute developmental programmed cell death in plants

Total Cost €

0

EC-Contrib. €

0

Partnership

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 EXECUT.ER project word cloud

Explore the words cloud of the EXECUT.ER project. It provides you a very rough idea of what is the project "EXECUT.ER" about.

plants    developmentally    crispr    events    mutagenesis    arabidopsis    multiplex    fundamental    compartmentalization    vital    lastly    accessibility    tissue    mechanisms    cell    proteomics    unprecedented    screens    health    me    improvement    lethality    mechanism    hypothesis    model    functions    organisms    orderly    fragmentary    significance    microscopy    sequencing    network    membrane    developmental    onset    team    single    live    despite    regulatory    underlying    quantum    enabled    shed    electron    acting    employ    revealing    cells    terminate    succession    irreversible    preliminary    de    proteins    context    programmed    preparation    sequential    central    genes    redundancy    data    overcome    temporal    correlative    final    breaks    multicellular    innovative    molecular    unexpected    light    permeabilization    protection    undoubted    spatial    reticulum    unparalleled    leap    crop    rna    unknown    death    super    rapid    technologies    gene    avenues    route    pcd    root    vacuole    reproduction    genetic    hypothesize    cap    plant    resolution    direct    endoplasmic    techniques   

Project "EXECUT.ER" data sheet

The following table provides information about the project.

Coordinator		 VIB VZW 

Organization address
address: RIJVISSCHESTRAAT 120
city: ZWIJNAARDE - GENT
postcode: 9052
website: www.vib.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Belgium [BE]
 Total cost 1˙999˙963 €
 EC max contribution 1˙999˙963 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-06-01   to  2025-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB VZW BE (ZWIJNAARDE - GENT) coordinator 1˙999˙963.00

Map

 Project objective

Programmed Cell Death (PCD) is fundamental to the development and health of multicellular organisms. However, our knowledge on developmentally controlled PCD in plants remains fragmentary, despite its undoubted significance for plant growth and reproduction. My team has established the Arabidopsis root cap as a novel model system for developmental PCD in plants. This model has enabled us to identify a gene regulatory network controlling the preparation of PCD. However, the molecular processes that terminate the vital functions of a plant cell during the final steps of PCD execution remain unknown. Exploiting the accessibility of the root cap for live-cell analysis of PCD execution, we obtained preliminary data revealing an unexpected succession of distinct membrane permeabilization events in which the endoplasmic reticulum breaks up before the central vacuole. I hypothesize that this sequential de-compartmentalization is the mechanism underlying the irreversible and orderly execution of PCD. Recent advances in several key technologies provide unprecedented opportunities to test this hypothesis and make a quantum leap in our understanding of the mechanisms carrying out PCD execution. I will employ correlative super-resolution light and electron microscopy to analyse PCD execution in unparalleled spatial and temporal resolution. RNA sequencing of single cells at the onset of PCD execution will provide information on the genes that are required for this rapid process. Advanced proteomics techniques will provide a direct route to identify proteins acting on membrane permeabilization during PCD execution. Lastly, multiplex and tissue-specific mutagenesis via innovative CRISPR screens will enable me to overcome genetic redundancy and lethality in the PCD context. The detailed understanding of plant PCD execution generated by this research program will shed light on a fundamental principle of plant development and open new avenues for crop improvement and protection.

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