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BraINstorm SIGNED

Engineered nanocarriers for simultaneous anticancer immune response and “switching” of tumor-associated macrophages for intranasal glioblastoma treatment

Total Cost €

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EC-Contrib. €

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Partnership

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 BraINstorm project word cloud

Explore the words cloud of the BraINstorm project. It provides you a very rough idea of what is the project "BraINstorm" about.

microenvironment    tumor    treatment    assessing    storm    complexity    appealing    re    surgery    strategy    ex    release    immunoconjugates    resection    combination    intranasal    treat    hyaluronic    muco    infiltrated    effect    route    prophylactic    drug    glioblastoma    antigen    tam    intrinsic    physical    explore    acid    immunomodulatory    parallel    model    vitro    invasive    regards    clinically    immunotherapy    chemical    conjugates    macrophage    size    mucosa    50    curable    peptides    radiotherapy    position    comprise    reduces    promotes    cpg    generating    blood    gbm    local    nasal    administration    invasiveness    explored    memory    barrier    biocompatibility    tackle    brain    emerged    turning    cells    immune    brainstorm    tumoral    therapeutic    preliminary    5    engineer    advantage    chemotherapy    performed    macrophages    oligonucleotide    m2    expansion    vivo    survival    m1    education    therapies    cancer    anticancer    oligonucleotides    conventional    patient    followed    lasting    standard    adhesivity    taas    crossing    types    disease    nose    rate    immunotherapeutic    precludes    switch    anti    stimulation    care   

Project "BraINstorm" data sheet

The following table provides information about the project.

Coordinator		 UNIVERSITE CATHOLIQUE DE LOUVAIN 

Organization address
address: PLACE DE L UNIVERSITE 1
city: LOUVAIN LA NEUVE
postcode: 1348
website: www.uclouvain.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Belgium [BE]
 Total cost 166˙320 €
 EC max contribution 166˙320 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-06-01   to  2022-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE CATHOLIQUE DE LOUVAIN BE (LOUVAIN LA NEUVE) coordinator 166˙320.00

Map

 Project objective

Glioblastoma (GBM) remains a non-curable disease due to its high complexity and its position beyond the blood-brain barrier, which precludes access by conventional therapies. The current standard of care includes tumor resection surgery followed by radiotherapy or chemotherapy; an invasive process with a survival rate after five years is less than 5%. Tumor-associated macrophages (TAM) type 2 (M2 macrophages) comprise 30-50% of the infiltrated cells in GBM microenvironment and support tumor expansion. Immunotherapy represents an appealing strategy to treat several cancer types by turning the immune system against tumor cells; tumor antigen peptides (TAAs) recently emerged as an immunotherapeutic approach that can provide for a long-lasting immune response. Immunomodulatory oligonucleotides can “switch” M2 macrophages into M1 macrophages that produce an anti-tumoral effect. The BraINstorm (Brain INtranasal storm) project aims to engineer a hyaluronic acid (HA)-based combination conjugates that tackle GBM by the stimulation of the immune system via the delivery of TAAs and an immunomodulatory oligonucleotide (CpG) that promotes M2 macrophage “re-education” generating an “anticancer storm”. In parallel, taking advantage of the intrinsic muco-adhesivity of HA, BraINstorm will explore the nose-to-brain drug delivery, a more patient-friendly route that reduces the invasiveness. Novel combination immunoconjugates will be fully chemical-physical characterized and preliminary in vitro studies will be performed assessing the biocompatibility, drug release, and nasal mucosa barrier crossing in an ex-vivo model. Finally, the prophylactic and therapeutic activity of the HA-based conjugates will be in vivo explored in a clinically relevant GBM in vivo model through intranasal (IN) and local treatment administration with regards to effects on tumor size, immune memory, and survival.

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The information about "BRAINSTORM" are provided by the European Opendata Portal: CORDIS opendata.

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