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Turbo-MPMI-Discovery SIGNED

TurboID-charging discovery of plant pathogen virulence and host resistance mechanisms

Total Cost €

0

EC-Contrib. €

0

Partnership

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 Turbo-MPMI-Discovery project word cloud

Explore the words cloud of the Turbo-MPMI-Discovery project. It provides you a very rough idea of what is the project "Turbo-MPMI-Discovery" about.

isolate    undertaking    interactions    employability    intracellular    multidisciplinary    msca    proximity    sensitive    pathogen    me    kingdoms    tcp14    activate    effectors    uk    biotin    skills    discovery    allele    vicinity    receptors    recognition    receptor    mpmi    identification    bioid    visibility    mobility    training    break    protein    albugo    inject    labelling    manipulate    shed    virulence    microbe    pl    chs3    bottleneck    leadership    advantage    ms    effector    temperatures    opportunity    light    capacity    active    boost    pairs    host    arabidopsis    pathogens    suppression    accelerate    modified    broad    chilling    benefit    confer    oomycete    alongside    professional    candida    canada    interactor    detect    tsl    proteins    plant    dramatically    transcription    tagged    turboid    international    interacting    molecular    extensive    ccg    ambient    goals    china    provides    taxonomic    immune    cells    transferrable   

Project "Turbo-MPMI-Discovery" data sheet

The following table provides information about the project.

Coordinator
THE SAINSBURY LABORATORY 

Organization address
address: Norwich Research Park, Colney Lane
city: NORWICH
postcode: NR47UH
website: http://www.tsl.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE SAINSBURY LABORATORY UK (NORWICH) coordinator 212˙933.00

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 Project objective

'Extensive studies in the field of Molecular Plant-Microbe Interactions (MPMI) show that pathogens inject virulence factors ('effectors') into host cells to manipulate host proteins and promote pathogen success. Recognition of effectors or their modified host proteins by plant intracellular receptors can activate immune responses. Identification of effector-host interactor (host target and intracellular receptor) pairs remains challenging. A more sensitive and specific approach to define effector-host interactor pairs would greatly accelerate discovery in plant-microbe interactions. Proximity labelling (PL) with biotin ('BioID') provides a novel method to detect proteins in the vicinity of a tagged protein. Taking advantage of the recently developed ('TurboID') allele that is highly active at ambient plant temperatures, the main goals of this project are to: 1) establish a sensitive and specific method (TurboID-based PL-MS) to identify effector-host interactor pairs; 2) use this method to identify host targets of 6 CCG effectors of oomycete Albugo candida that confer immune suppression to Arabidopsis; 3) isolate host target transcription factor TCP14-interacting effectors from pathogens from three taxonomic kingdoms, and to identify intracellular receptors CHS3 (Chilling sensitive 3)-interacting effectors. The method proposed here will break the bottleneck of defining effector-host interactor pairs and dramatically accelerate discovery in plant-microbe interactions. The identification of CCG effector targets will shed light on the strong immune suppression capacity of A. candida. My MSCA is a great opportunity for me to build on my previous international mobility from China to Canada and now to the UK, by undertaking advanced multidisciplinary ‘training-through-research’ at TSL. I shall benefit from broad technical and transferrable skills training alongside many dissemination opportunities to boost my professional visibility, leadership capacity and employability.'

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The information about "TURBO-MPMI-DISCOVERY" are provided by the European Opendata Portal: CORDIS opendata.

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