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InProSMod SIGNED

Cholinergic and NMDAR-dependent recruitment of Layer 1 Interneuron shapes cortical motor Processing through network States Modulation

Total Cost €

EC-Contrib. €

Partnership

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InProSMod project word cloud

Explore the words cloud of the InProSMod project. It provides you a very rough idea of what is the project "InProSMod" about.

motor implications termed operations cortical synaptic l1 imaging integration shown disorders circuit exhibit represented brain associative diverse layer generate dynamics computational whisking onto sensory input modulating mice spiking theoretical biophysics mouse levels spontaneous underlying awake thalamus interneurons valuable modeling profound normal cortex vivo inputs regimes barrel electrophysiology photon decoding network combination

Project "InProSMod" data sheet

The following table provides information about the project.

Coordinator	INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE Organization address address: BOULEVARD DE L'HOPITAL 47 city: PARIS postcode: 75013 website: http://icm-institute.org/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Total cost	184˙707 €
EC max contribution	184˙707 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2019
Funding Scheme	MSCA-IF-EF-ST
Starting year	2021
Duration (year-month-day)	from 2021-09-01 to 2023-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE Organization address address: BOULEVARD DE L'HOPITAL 47 city: PARIS postcode: 75013 website: http://icm-institute.org/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	coordinator	184˙707.00

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Project objective

In the sensory cortex of awake mice, spontaneous activity has been shown to exhibit various regimes, characterized by various levels of spiking activity. Such diverse activity regimes, termed network states, have a profound impact on the computational properties during sensory processing. In the mouse barrel cortex, a major top-down pathway modulating sensory input is represented by the integration of inputs from the motor cortex and associative thalamus onto layer 1 (L1). Here I will characterize the synaptic and circuit properties underlying top-down control of sensory network states during whisking in L1. Using a combination of synaptic biophysics, in vivo electrophysiology, 2-photon imaging and theoretical modeling, I will define the important role of L1 interneurons in decoding top-down processing of sensory information. This research will generate valuable information to advance our knowledge of cortical circuit dynamics during normal cortical operations, with crucial implications for several brain disorders.

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The information about "INPROSMOD" are provided by the European Opendata Portal: CORDIS opendata.