FISHBRAIN

Neural Circuits Underlying Visually Guided Behaviour

Coordinatore	FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD    more  Organization address address: AVENIDA BRASILIA city: LISBOA postcode: 1400 038 contact info Titolo: Dr. Nome: Tania Cognome: Vinagre Email: send email Telefono: 351210000000
Nazionalità Coordinatore	Portugal [PT]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2011-CIG
Funding Scheme	MC-CIG
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-09-01   -   2015-08-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD  Organization address address: AVENIDA BRASILIA city: LISBOA postcode: 1400 038 contact info Titolo: Dr. Nome: Tania Cognome: Vinagre Email: send email Telefono: 351210000000	PT (LISBOA)	coordinator	100˙000.00

Mappa

 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

 Obiettivo del progetto (Objective)

'A fundamental goal of neuroscience is to understand how information processing in neural circuits gives rise to behavior. Even the simplest actions can involve hundreds of neurons distributed throughout the brain. However, for most behaviors, little is known about which neurons play an important role, how they are organized into circuits, or how activity is transformed between different brain areas. The zebrafish model provides a unique opportunity to thoroughly dissect the neural basis of behavior in a vertebrate, due to their small, transparent brains, robust visual responses, and amenability to genetic manipulation. Using two-photon imaging, we can scan the entire area of the brain while monitoring the activity of individual neurons. This research programme aims to dissect the circuits underlying simple visually guided behaviors in larval zebrafish using a combination of state-of-the-art imaging, genetics and behavioral analysis. We propose to 1) perform a quantitative analysis of zebrafish behavior using high speed videography, and a custom designed arena for presentation of visual stimuli to freely swimming fish, 2) identify individual neurons and circuits that are active during these behaviors using two-photon imaging of fish expressing genetically encoded calcium indicators to and 3) perturb activity in these circuits using targeted single cell laser ablations and optogenetics. These experiments will map out the functional architecture of the zebrafish brain, revealing sets of neurons that comprise complete behavioral circuits in a vertebrate. Furthermore, they will provide an essential framework for the analysis of neural development, genetic mutants and disease models.'