EPICHEART

"Interplay of genetic, nutrient and lifestyle factors on incidence of coronary disease: EPIC-Heart"

Coordinatore	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	2˙499˙154 €
EC contributo	2˙499˙154 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2010-AdG_20100317
Funding Scheme	ERC-AG
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-05-01   -   2016-04-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	MEDICAL RESEARCH COUNCIL  Organization address address: NORTH STAR AVENUE POLARIS HOUSE city: SWINDON postcode: SN2 1FL contact info Titolo: Dr. Nome: Albert Cognome: Koulman Email: send email Telefono: +44 1223 426356	UK (SWINDON)	beneficiary	427˙676.89
2	VITAS AS  Organization address address: GAUSTADALLEEN 21 city: OSLO postcode: 349 contact info Titolo: Ms. Nome: Marit Cognome: Markhus Email: send email Telefono: +47 22 95 84 61	NO (OSLO)	beneficiary	170˙302.22
3	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE  Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Ms. Nome: Renata Cognome: Schaeffer Email: send email Telefono: +44 1223 765193 Fax: +441223 765410	UK (CAMBRIDGE)	hostInstitution	1˙901˙175.29
4	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE  Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Prof. Nome: John Navid Cognome: Danesh Email: send email Telefono: +44 1223 741302 Fax: +44 1223 741339	UK (CAMBRIDGE)	hostInstitution	1˙901˙175.29

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 Obiettivo del progetto (Objective)

'A major new frontier in biomedicine is to identify interactions of specific components of nature and nurture in determining risk of complex diseases. Coronary heart disease (CHD) - the single leading cause of death in Europe - is jointly determined by genetic and lifestyle factors. It is unknown, however, how diet, nutrients, and lifestyle factors modulate genetic susceptibility. For scientific and public health reasons, there is a strategic need to study such interactions reliably. There is a unique opportunity for a cost-effective and powerful study because we have: -conducted detailed assessment of diet and other lifestyle factors in 520K participants in a pan-European prospective study -identified >12K incident CHD cases accrued during >5M person-years at risk -identified a random sub-cohort of >15K participants without CHD to serve as referents -commenced assay of lipid and other markers in 12K cases and 15K referents -prepared DNA for genetic assay. In 12K CHD cases and 15K referents, we will assay: >217K genetic variants contained in the state-of-the-art metabochip; 37 fatty acids; and vitamin D metabolites. Analyses will focus on: discovery of interactions; causal evaluation of biomarkers; CHD risk scores. The findings should open new horizons and contribute towards: 1) explaining missing heritability 2) shaping nutritional guidelines 3) personalising preventive medicine 4) defining approaches to modify genetic susceptibility by avoiding deleterious lifestyles 5) identifying biomarkers that are priority therapeutic targets and 6) innovative prognostic tools. Gene-lifestyle interplay is a major future growth area. This world-leading study will enhance Europes strengths in public health, nutrition and genetic epidemiology, and create a valuable future resource.'