UNCOVER

Evaluation and development of measures to uncover and overcome bias due to non-publication of clinical trials

Coordinatore	AIT Austrian Institute of Technology GmbH    more  Organization address address: Donau-City-Strasse 1 city: WIEN postcode: 1220 contact info Titolo: Mr. Nome: Felix Cognome: Schröpfer Email: send email Telefono: +43 50550 2069 Fax: +43 50550 2097
Nazionalità Coordinatore	Austria [AT]
Totale costo	683˙804 €
EC contributo	498˙801 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2011-single-stage
Funding Scheme	CSA-SA
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-09-01   -   2014-06-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	AIT Austrian Institute of Technology GmbH  Organization address address: Donau-City-Strasse 1 city: WIEN postcode: 1220 contact info Titolo: Mr. Nome: Felix Cognome: Schröpfer Email: send email Telefono: +43 50550 2069 Fax: +43 50550 2097	AT (WIEN)	coordinator	277˙592.84
2	UNIVERSITAET FUER WEITERBILDUNG KREMS  Organization address address: DR.-KARL-DORREKSTRASSE 30 city: KREMS postcode: 3500 contact info Titolo: Prof. Nome: Edith Cognome: Huber Email: send email Telefono: +43 2732 2223 Fax: +43 2732 4210	AT (KREMS)	participant	147˙818.00
3	THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL  Organization address address: AIRPORT DRIVE 104 SUITE 2200 CB #1350 city: CHAPEL HILL postcode: 27599 contact info Titolo: Prof. Nome: Tony G. Cognome: Waldrop Email: send email Telefono: +1 919 966 3411 Fax: +1 9199623352 5011	US (CHAPEL HILL)	participant	73˙391.00

Mappa

 Word cloud

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 Obiettivo del progetto (Objective)

'The UNCOVER project is a direct contribution to overcome non-publication of clinical studies that have been designed and executed as randomized controlled trials (RCTs). RCTs provide the best utility as input to systematic medicinal reviews, one cornerstone of evidence-based medicine. That is provided that, and only then, RCTs are both correctly registered and published at least once. Because non-publication, as well as publication with time delay of RTCs, can decisively reduce the advantage of such systematic reviews of drugs, medical devices or procedures, it affects the knowledge base, patient value, and level of public health. UNCOVER’s aim is three-fold: 1) to apply established and develop novel, solid, and useful methods for fact-finding and interventions into the socio-economic system defined by causes and sources of the publication bias; 2) to engage with stakeholders and identify strategies, barriers, and facilitating factors associated with the publication bias and its consequences; and 3) to synthesize lessons learned and recommend feasible measures to deal with the publication bias. In a perspective way, this project contributes pro better allocation of funds to sponsor studies and patient value, and contra duplication of work and patients risk. The issues of the publication bias are treated with quantitative, qualitative and participatory means (including tools such as stakeholder maps, institutional analysis, case studies, systematic reviews, interviews, bibliometric analysis and software) in an interdisciplinary approach in areas with little or no lines of evidence as to how they perform in practice. UNCOVER will thus both provide viable solutions for the publication bias, for better allocation efficiency of medicinal and health related research funds, and develop methodologies for future bias research efforts.'

Introduzione (Teaser)

Clinical trials (CTs) evaluate the effectiveness and safety of medications, medical devices or medical procedures by monitoring their effects on large groups of people. EU-funded researchers investigated the effect of publication bias in CTs and provided recommendations to overcome this bias.