GENODISC

Disc-degeneration linked pathologies: novel biomarkers and diagnostics for targeting treatment and repair

Coordinatore	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD    more  Organization address address: University Offices, Wellington Square city: OXFORD postcode: OX1 2JD contact info Titolo: Mr. Nome: Stephen Cognome: Conway Email: send email Telefono: 441865000000 Fax: 441865000000
Nazionalità Coordinatore	United Kingdom [UK]
Sito del progetto	http://www.physiol.ox.ac.uk/genodisc/index.html
Totale costo	4˙007˙552 €
EC contributo	2˙997˙144 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2007-A
Funding Scheme	CP-FP
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-03-01   -   2013-02-28

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD  Organization address address: University Offices, Wellington Square city: OXFORD postcode: OX1 2JD contact info Titolo: Mr. Nome: Stephen Cognome: Conway Email: send email Telefono: 441865000000 Fax: 441865000000	UK (OXFORD)	coordinator	0.00
2	"NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS"""  Organization address address: Patriarchou Gregoriou Str. city: AGHIA PARASKEVI postcode: 15310 contact info Nome: Marina Cognome: Fontara Email: send email Telefono: 302107000000 Fax: 302107000000	EL (AGHIA PARASKEVI)	participant	0.00
3	BUDAI EGESZSEGKOZPONT KFT  Organization address address: NAGY JENO UTCA 8 city: BUDAPEST postcode: H-1126 contact info Titolo: Dr. Nome: Péter Pál Cognome: Varga Email: send email Telefono: 3618877988 Fax: 3618877987	HU (BUDAPEST)	participant	0.00
4	EDUCELL PODJETJE ZA CELICNO BIOLOGI JO DOO  Organization address address: Letaliska city: LJUBLJANA postcode: 1000 contact info Titolo: Ms. Nome: Anja Cognome: Tajhmajster Email: send email Telefono: +386 1 5471 842 Fax: +386 1 5471 842	SI (LJUBLJANA)	participant	0.00
5	HELSINGIN YLIOPISTO  Organization address address: YLIOPISTONKATU 4 city: HELSINGIN YLIOPISTO postcode: 14 contact info Titolo: Ms. Nome: Tiina Cognome: Berg Email: send email Telefono: +358 9 191 25129 Fax: +358 9 191 25044	FI (HELSINGIN YLIOPISTO)	participant	0.00
6	ISTITUTO ORTOPEDICO GALEAZZI  Organization address address: VIA GALEAZZI 4 city: MILANO postcode: 20161 contact info Titolo: Ms. Nome: Elena Angela Maria Cognome: Bottinelli Email: send email Telefono: +39 02 66214850	IT (MILANO)	participant	0.00
7	TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY  Organization address address: TECHNION CITY - SENATE BUILDING city: HAIFA postcode: 32000 contact info Titolo: Mr. Nome: Mark Cognome: Davison Email: send email Telefono: +972 4 829 4854 Fax: +972 4 823 2958	IL (HAIFA)	participant	0.00
8	TECHNISCHE UNIVERSITEIT EINDHOVEN  Organization address address: DEN DOLECH 2 city: EINDHOVEN postcode: 5612 AZ contact info Titolo: Mr. Nome: J. (Rob) M.R. Cognome: Debeij Email: send email Telefono: +31 40 247 5135 Fax: +31 40 247 2206	NL (EINDHOVEN)	participant	0.00
9	UNIVERSITAET ULM  Organization address address: HELMHOLTZSTRASSE 16 city: ULM postcode: 89081 contact info Nome: Frank Cognome: Gleixner Email: send email Telefono: +49 731 500 66397 Fax: +49 731 500 66392	DE (ULM)	participant	0.00
10	UNIVERSITY OF KEELE  Organization address address: KEELE UNIVERSITY FINANCE DPT city: KEELE postcode: ST5 5BG contact info Titolo: Ms. Nome: Judith Cognome: Garside Email: send email Telefono: 441783000000 Fax: +44 1782 583740	UK (KEELE)	participant	0.00

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 Obiettivo del progetto (Objective)

'Disorders arising from degeneration of the intervertebral disc are an enormous clinical and financial burden on European societies. Most of the burden arises from 10% of patients who become chronically disabled. Any factor which will improve treatment of back pain sufferers or prevent development of chronic disability would have an important impact both on society and in improving quality of life of patients. Improving diagnosis is the key. At present, 85% of patients have no clear diagnosis resulting in arbitrary treatments, usually surgical, which range widely from centre to centre and are often ineffective. Without clear diagnostic criteria, treatments and preventative measures cannot be targeted effectively. Patients may be subjected to unnecessary and expensive interventions or else denied treatment which could be beneficial Scientific advances in understanding the aetiopathology of these disorders are necessary for development of objective diagnostic criteria, rational application of present treatments and development of new therapies. Genodisc aims to contribute to improvement of patient care through improving diagnosis of disc-related pathologies both by more effective utilisation of present diagnostic information and by developing novel diagnostic tools. Through these new diagnostic methods, it aims to select patients at risk of chronic low back pain and spinal stenosis. It also aims to develop criteria for selecting patients who will benefit from newly emerging biological therapies for treating disc degeneration. The scientific advances underpinning improved diagnosis will arise from genotyping carefully phenotyped patients, from research into the processes of disc degeneration and from models of how these molecular processes lead to disc failure. This research will potentially provide biomarkers which will increase diagnostic specificity and provide targets for development of drug therapies.'