MEVIC

Molecular engineering of virus-like carriers

Coordinatore	more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Non specificata
Totale costo	1˙643˙736 €
EC contributo	16 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-10-01   -   2016-09-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE UNIVERSITY OF SHEFFIELD  Organization address address: FIRTH COURT WESTERN BANK city: SHEFFIELD postcode: S10 2TN contact info Titolo: Ms. Nome: Joanne Cognome: Watson Email: send email Telefono: +44 114 222 4754 Fax: +44 114 222 1455	UK (SHEFFIELD)	beneficiary	436˙830.70
2	UNIVERSITY COLLEGE LONDON  Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT contact info Titolo: Mr. Nome: Giles Cognome: Machell Email: send email Telefono: +44 20 3108 3020 Fax: +44 20 7813 2849	UK (LONDON)	hostInstitution	1˙206˙905.40
3	UNIVERSITY COLLEGE LONDON  Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT contact info Titolo: Prof. Nome: Giuseppe Cognome: Battaglia Email: send email Telefono: +44 20 7679 4688 Fax: +44 20 7813 2849	UK (LONDON)	hostInstitution	1˙206˙905.40

Mappa

 Word cloud

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 Obiettivo del progetto (Objective)

'In the last 5 years I have been working on the study of nanoscopic vesicles formed by the assembly in water of amphiphilic block copolymers. These polymer vesicles also known as polymersomes can be designed with size, topology and morphology similar to natural viruses. The synthetic nature of copolymers allows the design of interfaces with various classes of biochemically-active functional groups. This, in combination with precise control over the molecular architecture, determines the degree of order in self-organizing polymeric materials. Such bio-inspired ‘bottom-up’ supramolecular design principles can offer outstanding advantages in engineering structures at a molecular level, using the same long–studied principles of biological molecules. It is self-evident that the highly biocompatible nature of these new amphiphilic copolymer assemblies augurs well for biomedical applications. Indeed, related polymeric micelles and vesicles have already been reported and studied as delivery systems for drugs, gene, and image contrast agents. Herein I propose to engineer new generations of polymersomes whose size, topology, surface chemistry is exquisitely controlled by supramolecular interactions with the aim to control their bioactivity and explore new ways to target specific biological sites via multi-fictionalisation and steric controlled binding. This will be achieved by a balanced combination of novel physico-chemical techniques with tailor-made biological evaluation based on state-of-the-art cell culture methods as well as in vitro and in vivo high content screening. My long-term aim is to set-up new design principles for nanoparticles for biomedical applications together with a thorough biomedical fast screening that will enable safe and fast translation into the clinic as well as benchmarking nanotoxicological methodologies.'