METACLOCK
Metabolic oscillations and the 24 hour (circadian) clockwork
| Coordinatore | THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
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| Nazionalità Coordinatore | United Kingdom [UK] |
| Totale costo | 1˙998˙056 € |
| EC contributo | 1˙998˙056 € |
| Programma | FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | ERC-2011-StG_20101109 |
| Funding Scheme | ERC-SG |
| Anno di inizio | 2011 |
| Periodo (anno-mese-giorno) | 2011-10-01 - 2016-09-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Organization address
address: The Old Schools, Trinity Lane contact info |
UK (CAMBRIDGE) | hostInstitution | 1˙998˙056.00 |
| 2 |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Organization address
address: The Old Schools, Trinity Lane contact info |
UK (CAMBRIDGE) | hostInstitution | 1˙998˙056.00 |
Mappa
Word cloud
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Obiettivo del progetto (Objective)
'We live in a '24 hour' culture, with transatlantic air travel and shift-work being part of normal life for many people. These types of desynchronisations (e.g. “jet-lag”) disrupt our daily physiology and are increasingly being linked to diseases such as diabetes, obesity and cancer. Daily rhythms are also impaired in the elderly, and in patients with common neurodegenerative conditions such as Alzheimer-type and fronto-temporal dementias, meaning that clock disruption is widespread in modern society. We know that every cell in the body has its own molecular clock, allowing it to coordinate its daily activities accurately, just as we would use a clock in our daily lives. Our work has uncovered novel mechanisms about how this works and how this fundamental timing system may have evolved in primitive single-celled organisms. By understanding these basic cellular mechanisms in greater detail, we anticipate that we will gain insights into how metabolic oscillations in each cell contribute to normal physiology and therefore disease.'