TRIPLOID BLOCK

Mechanisms of polyploidy-mediated postzygotic reproductive isolation

Coordinatore	SVERIGES LANTBRUKSUNIVERSITET    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Sweden [SE]
Totale costo	1˙447˙596 €
EC contributo	1˙447˙596 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2011-StG_20101109
Funding Scheme	ERC-SG
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-10-01   -   2016-09-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	SVERIGES LANTBRUKSUNIVERSITET  Organization address address: ARRHENIUSPLAN 4 city: UPPSALA postcode: 75007 contact info Titolo: Prof. Nome: Claudia Cognome: Köhler Email: send email Telefono: +46 18 67 3313 Fax: +46 18 67 3389	SE (UPPSALA)	hostInstitution	1˙447˙596.00
2	SVERIGES LANTBRUKSUNIVERSITET  Organization address address: ARRHENIUSPLAN 4 city: UPPSALA postcode: 75007 contact info Titolo: Prof. Nome: Eva Cognome: Sundberg Email: send email Telefono: +46 18 67 3245	SE (UPPSALA)	hostInstitution	1˙447˙596.00

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 Obiettivo del progetto (Objective)

'Polyploidization is a widespread phenomenon among plants and is considered a major speciation mechanism. Before becoming evolutionary successful, newly formed polyploids often have to overcome fertility bottlenecks, because mating with partners of lower ploidy causes incompatibilities in the endosperm leading to the formation of mainly non-viable progeny. This reproductive barrier is called the triploid block. Nevertheless, the most frequent route to polyploid formation is probably through unreduced gametes, suggesting that the triploid block can be overcome. Recent work from our laboratory uncovered a genetic pathway leading to unreduced gamete formation at high frequency and revealed that the triploid block is mainly caused by malfunction of Polycomb group (PcG) proteins. PcG proteins are evolutionary conserved proteins, which assemble into multimeric complexes with chromatin-modifying enzymatic activity, implicating epigenetic regulatory mechanisms as an important element of speciation. Here, I propose to unravel the underlying molecular mechanism(s) of the triploid block by identifying the responsible genes causing endosperm failure upon deregulation and their mechanism of regulation in response to interploidy crosses. I also plan to investigate whether genes that contribute to the triploid block are as well responsible for establishing interspecies incompatibilities within the Arabidopsis genus. This project will combine genetics, genomics and epigenomics and will make extensive use of knowledge and tools that we have been established in my laboratory over the recent years, making it likely that the proposed objectives can be achieved. The results of this project will be of interest to a broad scientific community, including biologists with a strong interest in epigenetic mechanisms as well as ecologists interested to understand mechanisms of plant speciation.'