TRIPLOID BLOCK

Mechanisms of polyploidy-mediated postzygotic reproductive isolation

 Coordinatore SVERIGES LANTBRUKSUNIVERSITET 

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 Nazionalità Coordinatore Sweden [SE]
 Totale costo 1˙447˙596 €
 EC contributo 1˙447˙596 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2011-StG_20101109
 Funding Scheme ERC-SG
 Anno di inizio 2011
 Periodo (anno-mese-giorno) 2011-10-01   -   2016-09-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    SVERIGES LANTBRUKSUNIVERSITET

 Organization address address: ARRHENIUSPLAN 4
city: UPPSALA
postcode: 75007

contact info
Titolo: Prof.
Nome: Claudia
Cognome: Köhler
Email: send email
Telefono: +46 18 67 3313
Fax: +46 18 67 3389

SE (UPPSALA) hostInstitution 1˙447˙596.00
2    SVERIGES LANTBRUKSUNIVERSITET

 Organization address address: ARRHENIUSPLAN 4
city: UPPSALA
postcode: 75007

contact info
Titolo: Prof.
Nome: Eva
Cognome: Sundberg
Email: send email
Telefono: +46 18 67 3245

SE (UPPSALA) hostInstitution 1˙447˙596.00

Mappa

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 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

evolutionary    block    pcg    overcome    responsible    incompatibilities    laboratory    recent    unreduced    proteins    genes    triploid    speciation    mainly    mechanisms    endosperm    epigenetic    mechanism   

 Obiettivo del progetto (Objective)

'Polyploidization is a widespread phenomenon among plants and is considered a major speciation mechanism. Before becoming evolutionary successful, newly formed polyploids often have to overcome fertility bottlenecks, because mating with partners of lower ploidy causes incompatibilities in the endosperm leading to the formation of mainly non-viable progeny. This reproductive barrier is called the triploid block. Nevertheless, the most frequent route to polyploid formation is probably through unreduced gametes, suggesting that the triploid block can be overcome. Recent work from our laboratory uncovered a genetic pathway leading to unreduced gamete formation at high frequency and revealed that the triploid block is mainly caused by malfunction of Polycomb group (PcG) proteins. PcG proteins are evolutionary conserved proteins, which assemble into multimeric complexes with chromatin-modifying enzymatic activity, implicating epigenetic regulatory mechanisms as an important element of speciation. Here, I propose to unravel the underlying molecular mechanism(s) of the triploid block by identifying the responsible genes causing endosperm failure upon deregulation and their mechanism of regulation in response to interploidy crosses. I also plan to investigate whether genes that contribute to the triploid block are as well responsible for establishing interspecies incompatibilities within the Arabidopsis genus. This project will combine genetics, genomics and epigenomics and will make extensive use of knowledge and tools that we have been established in my laboratory over the recent years, making it likely that the proposed objectives can be achieved. The results of this project will be of interest to a broad scientific community, including biologists with a strong interest in epigenetic mechanisms as well as ecologists interested to understand mechanisms of plant speciation.'

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