METASTASIS

Evaluation of metastatic and angiogenic potential of cancer stem-like cells in distinct mouse models for lung and liver metastasis

Coordinatore	FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA    more  Organization address address: AVENIDA DE PIO XII 55 city: PAMPLONA postcode: 31008 contact info Titolo: Dr. Nome: Andrew Cognome: Solomon Email: send email Telefono: 34948194700 Fax: 34948194718
Nazionalità Coordinatore	Spain [ES]
Totale costo	167˙065 €
EC contributo	167˙065 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2010-IIF
Funding Scheme	MC-IIF
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-11-01   -   2014-03-05

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA  Organization address address: AVENIDA DE PIO XII 55 city: PAMPLONA postcode: 31008 contact info Titolo: Dr. Nome: Andrew Cognome: Solomon Email: send email Telefono: 34948194700 Fax: 34948194718	ES (PAMPLONA)	coordinator	167˙065.60

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 Obiettivo del progetto (Objective)

'Metastasis disease is the leading cause of cancer-related mortality with very few effective treatment options available for patients. Metastases are characterized by the presence of vascular proliferation, a subpopulation of stem-like cells and infiltration by various bone marrow derive cells (BMDCs). BMDCs have been shown to provide the premetastatic niches that promote the angiogenic process and create an environment permissive for tumor cell homing and colonization. The cancer stem cell (CSC) theory defines a subset of cancer cells with the exclusive ability to drive the growth and spread of a tumor. This research proposal is founded on the hypothesis that the CSC theory also applies to the metastasic process. The aims are to determine the relative contribution of CSCs to tumor cell homing, their ability to recruit BMDCs and induce angiogenesis. The final goals are to elucidate the mechanisms that participate in these phenomena and to develop novel therapeutic strategies to overcome metastasis initiation and progression.

Briefly, using well-defined models of lung and liver metastasis, we will 1- determine if CSCs are more metastatic and angiogenic than non-CSCs; 2- identify the genes responsible for the metastatic and angiogenic capacity; 3- characterize the role of CSCs in the recruitment of BMDC; 4- examine whether cancer cells secrete factors that directly activate myeloid cells to produce tumor-promoting cytokines; 5- quantify the number of CSCs in samples from patients with lung and liver metastasis and validate their metastatic potential.'